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Rheumatoid Arthritis - Wiley Online Library

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Last Updated: 22 June 2022

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Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

Rheumatoid arthritis is a systemic chronic disease characterized by inflammation and synovitis. On the 0th day of the experiment, the control group received 1 ml of saline orally beginning from the 8th day, and 0. 2 ml of CFA was distributed to the RA, RA + Safranal, and Methotrexate groups. Starting from the 8th day of the experiment, safranal was given 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX were distributed to the RA+ MTX group twice a week. The results showed that weight gain in the RA group was reduced in comparison to the control group, although arthritis index score, thymus index, and planter temperature were all increased. In addition, histopathological investigation revealed that safranal reduced inflammatory cell infiltration and edema.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbt.23140


Therapeutic role of hesperidin in collagen‐induced rheumatoid arthritis through antiglycation and antioxidant activities

To make a RA model of rats, collagen type II suspension was applied to Wistar rats in this research. After undergoing bone damage therapy with hesperindin, Xx-U2010rays of the rat hind paws were analyzed and found to be highly effective against bone loss. After treating with hesperidin, the elevated CML levels in plasma and in IgG were dramatically reduced to 450. 95 mg U22121 IgG, respectively, with the exception of a 0. 23 ng mg mgg. According to a similar study, PTD in plasma and IgG of rats treated with hesperidin were 28. 46 percent and 359. 35 percent respectively, with 36. 11 ng gu22121 IgG respectively. PTD levels were restored to 93% and 16%, respectively, after undergoing drug, plasma CML, and IgG PTD treatment, resulting in relief of RA disease by lowering the AGEs levels. Therefore, use of hesperidin may be useful in reducing the severity of RA disease.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbf.3708


Polymorphism of protein tyrosine phosphatase non‐receptor type 22 and protein arginine deiminase 4 gene among Ghanaian rheumatoid arthritis patients: A case–control study

Generally among Caucasians and Asians, the relationship between genetic predisposition and RA has been largely confirmed. However, only in Ghana has reported genome-wide association studies of RA in Africa, especially in Ghana. This research also investigated the connection between protein arginine deiminase type 4 and protein tyrosine phosphatase non-u2010receptor type 22 single nucleotide polymorphisms in Ghanaians with susceptibility to RA.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.14348


Engineering approaches to investigate the roles of lymphatics vessels in rheumatoid arthritis

Rheumatoid arthritis is one of the most common chronic joint disorders. Rapid changes in LV structure and interstitial fluid drainage have been shown to correlate with significant changes in LV anatomy and interstitial fluid drainage, resulting in the retention of distinct immune cell phenotypes within the synovium. LVs in RA experience an initial growth phase of increased LVs and abnormal contractions, followed by a collapsed phase of reduced lymphatic function and immune cell clearance in vivo, as demonstrated by advances in dynamic imaging technologies. However, current animal models of RA fail to decouple biological and biophysical causes that may be responsible for this lymphatic dysfunction in RA, and a few experimental in vitro models of the synovium in RA haven't yet included the contributions from the LVs. This paper explores the roles of LVs in RA and the latest engineering techniques to help our knowledge of lymphatic pathophysiology in RA.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/micc.12769


Successful control of menstrual cycle‐related exacerbation of inflammatory arthritis with GnRH agonist with add‐back therapy in a patient with rheumatoid arthritis

Patients with rheumatoid arthritis may experience changes in arthritis symptoms related to the menstrual cycle. Her arthritis symptoms began ten days before her menstruation and swiftly recovered after menstruation began. This case shows that rheumatoid arthritis disease activity can be correlated with the menstrual cycle, and hormonal therapy may be helpful as an adjunct therapy for preventing premenstrual exacerbation of rheumatoid arthritis.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jog.15287


Chemical constituents, biological activities and anti‐rheumatoid arthritic properties of four citrus essential oils

Rheumatoid arthritis is a chronic systemic autoimmune disease with a predominant synovitis with a persistent synovitis that has no cure or preventive therapy. Citrus sinensis Osbeck, Citrus paradisi Macfad's original oils were hydrodistilled from the peels of four citrus species in this report. All four essential oils had excellent antioxidant activity, according to the dependable 1,1 u2010diphenyl, u20102'u2010pyrrole hydrazine free radical analysis. The four primary oils blocked the expression of tumor necrosis factoru2013b1 and cyclooxygenaseu20102 in a rat model that was similar to that of the common drug, Ibuprofen, according to an immunohistochemical analysis.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.7484

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions