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Any cellular components of the joint capsule's inner layer, also known as the synoviocyte-like synoviocytes or synovial fibroblasts, are vital cellular components of the synovial membrane. They can be present in both layers of this synovial membrane and contribute to normal joint function by supplying extracellular matrix components and lubricants, and can be found in both layers of this synovial membrane. In RA, we want to give an overview of our current knowledge of the target potential of these cells.
Source link: https://doi.org/10.1136/annrheumdis-2021-222021
Nintedanib, a multi-tyrosine kinase inhibitor that is commonly used to treat progressive interstitial lung disease because it slows the loss of forced vital capacity. However, the prognosis for patients treated with nintedanib is poor. We investigated the effects of nintedanib on gene expression in the lungs of induced-rheumatoid arthritis-associated interstitial lung disease model mice, which exhibit rheumatoid arthritis and subsequent pulmonary fibrosis. The differentially expressed genes for mucin 5B and heat shock protein 70 family genes, which are related to interstitial lung diseases, as well as genes associated with extracellular components, especially the myocardial architecture, were associated with the unanticipated effects of nintedanib. Thus, the present results reveal a series of genes whose expression modification could possibly explain the effects of nintedanib on pulmonary fibrosis. These findings are expected to aid in the creation of new nintedanib-based therapy of progressive fibrosing interstitial lung diseases.
Source link: https://doi.org/10.1371/journal.pone.0270056
Cold atmospheric plasma inhibits cancer cells and may have anti-inflammatory capabilities, according to previous studies. This paper investigated the effects of argon plasma jet-produced CAP on the suppression of invasion and inflammation caused by cultured RA-FLS. CAP decreased cell viability and increased the percentage of apoptotic RA-FLS by producing reactive oxygen species, according to the results. The CAP, according to Carboxyfluorescein diacetate succinimidyl ester staining, has reduced RA-FLS's replication. These results suggest that CAP could be a promising treatment for slowing RA progression by reducing tumor-like features and inflammation in RA-FLS.
Source link: https://doi.org/10.1007/s10753-022-01703-3
Rheumatoid arthritis is a chronic inflammatory disorder that is characterized by synovial inflammation in multiple joints. Triptolide is a disease-modifying anti-rheumatic drug that is particularly effective in patients with RA and has anti-inflammatory properties. TP-containing hyaluronic acid hydrogel-loaded RGD-attached gold nanoparticles were synthesized in the present study to reduce the toxicity and improve therapeutic specificity. Hydrogel systems with tyramine-modified HA conjugates have been applied to artificial tissue models as surrogates of cartilage to study drug transport and release properties. Heat was locally generated at the inflammation region site after the degradation of HA chains by near-infrared resonance irradiation of AuNPs, and TP was released from nanoparticles, providing heat and medication to the inflamed joints simultaneously. With NIR light, RA can be penetrated. The hydrogels containing a low amount of TP with NIR irradiation improved the inflammation in mice with collagen-induced arthritis.
Source link: https://doi.org/10.3389/fphar.2022.849101
Increase osteoclastic bone resorption and reduced osteoblastic bone formation in RA bone loss, which includes bone erosion, periarticular bone loss, and systemic osteoporosis. Synovial fibroblasts contribute to joint injury by stimulating both pro-inflammatory and tissue-destructive pathways. It's crucial to know how the immune system supports bone damage in RA to determine bone injury mechanisms. The interaction of immune cells and fibroblasts underlies the discreption between regulatory T cells and T helper 17 cells, which in turn promotes not only inflammation but also bone fibroblasts, mainly because it promotes RANKL expression on synovial fibroblasts. An improved understanding of the immune system underlying joint injury, synovial fibroblasts, and bone can aid in the identification of new therapeutic targets in RA.
Source link: https://doi.org/10.1038/s41584-022-00793-5
A slew of curative drugs is replete with a slew of therapeutic drugs, however unvalidated scientifically but with apparently miraculous results. The use of N. . . . ian herbal remedies in the treatment and management of RA has been enhanced by studies of the identification of bioactive compounds in these botanicals using advanced spectral analytical methods. Interestingly, experimental results show that the bioactive compounds present in plant botanical extracts shielded animals from the onset of RA in various experimental models and reduced the toxicity associated with conventional therapeutics. We explore the global burden of RA, the discovery of plant-based botanicals as potential therapeutics against signaling pathways in RA in this mini-review. With a global outlook, we are also concerned about the possibility of repurposing/reprofiling plant botanicals to raise their therapeutic index among RA patients who patronize traditional healers in N. . . . ia.
Source link: https://doi.org/10.1177/15353702221102901
Using numerical simulations, this research is aimed at discovering the key rheumatoid arthritis targets in traditional Chinese medicine and determining the key rheumatoid arthritis targets. Using AutoDock Vina, potential RA targets were identified using the Gene Expression Omnibus database, protein-protein interaction network, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment studies and potential TCM components were identified. In total, there were results for 432 TCM active ingredients with good pharmacological activity. According to a target prediction and network-based proximity study, dioscin could modulate 22 known RA clinical goals. In RA rat synovial cells, Dioscin, asiaticoside, and ginsenoside Re can all reduce in vitro cell proliferation and secretion of TNF-u03b1 and IL-1u03b2. Dioscin could significantly reduce proliferation and induce apoptosis in RA rat synovial cells by reducing TNF-u03b1 and IL-1u03b2 secretion while also inhibiting abnormal CCL5, CXCR2, and IL2 expression.
Source link: https://doi.org/10.1155/2022/1905077
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