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Rheumatoid Arthritis - DOAJ

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Last Updated: 22 June 2022

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Potential role of HBV DNA-induced CD8 T cell apoptosis in patients with systemic lupus erythematosus and rheumatoid arthritis

paraphrased arthritis patients with systemic lupus erythematosus and rheumatoid arthritis should have an investigation into the possibility of hepatitis B virus DNA-induced CD8 apoptosis in patients with systemic lupus erythematosus and rheumatoid arthritis. Since peripheral blood mononuclear cells were stimulated with HBV DNA, peripheral blood mononuclear cells were stimulated with HBV DNA, the apoptosis of T cell subgroups was confirmed. Patients with active SLE were more likely than those with inactive SLE, with T cell counts in CD4+u2212 CD8 increased. However, CD4 u2212 CD8 T cell counts in patients with active RA patients were lower than in those with inactive RA.

Source link: https://doi.org/10.1177/03000605221104760


Inadequate Dietary Nutrient Intake in Patients With Rheumatoid Arthritis in Southwestern Sweden: A Cross-Sectional Study

Although this may lead to a nutritionally deficient diet among Swedish patients with RA, up-to-date, comprehensive account of the nutrient intake in Swedish patients with RA is lacking. The aim of this study was to examine patients with RA living in southwestern Sweden's habitual dietary energy and nutrient intake. Results of the survey were analyzed using The Swedish Food Composition Database, a database of energy and nutrients. The consumption of energy and nutrients was determined by the participants. The Swedish Food Composition Database was used to analyze a total of 62 participants, where 18 participants achieved one 3-day food record and 44 participants completed two 3-day food records. Females and males, respectively, reported that vitamin A intake was especially poor, and did not reach a lower intake level for 14 and 17% of females and males.

Source link: https://doi.org/10.3389/fnut.2022.915064


A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis

TLR4/PI3K/NF-BIGZD effective gene modulation during RA progression was tested by a collaborator based on the interaction network of the u201cRA-related geneu201d-related gene. Based on the in vitro pyroptosis cell cultures of RAW264. 7 and MH7A cells induced by LPS/ATP, consistent results were obtained. These findings reveal that the MG and CA combination obtained from BHGZD may interact with TLR4/AKT/NFu03baB signaling to reduce NLRP3 inflammasome production and modulate pyroptosis, which provides the novel BACs and pharmacological mechanisms of BHGZD against active RA. Our findings may reveal new light on the TCM's internals and facilitate the modernization of TCM and drug discovery.

Source link: https://doi.org/10.3389/fimmu.2022.912933


SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review

Secretly-related protein 1 is a member of the SFRP family. SFRP1 is a common gene that controls cell growth, development, and transformation in human cells, including many cancer cells and fibroblast-like synoviocytes of rheumatoid arthritis. These are helpful in determining the genetic signatures of SFRP1 in RA, particularly the way that SFRP1 regulates RA-FLS pyroptosis by Wnt/u03b2-catenin and Notch signaling pathways.

Source link: https://doi.org/10.3389/fimmu.2022.903475


Pulmonary Function Test in Rheumatoid Arthritis Patients

Lung disease is a common and significant contributor to morbidity and mortality in rheumatoid arthritis patients. And in RA patients with no respiratory problems, diagnostic techniques can reveal hidden pulmonary diseases in RA patients with no respiratory problems, according to a report. We looked at respiratory function testing and chest radiographs in RA patients with more than three years of illness in order to find a suitable tool for prospecting RA-induced lung diseases in this research. Patients were divided into three categories based on the FEV1/FVC ratio, with FEV1/FVC below 70% in 5% and between 70% and 85% in 50%, and above 85% in 45% of RA patients. Normal X-ray was the most common finding in CXR, but only cystic changes and reticular changes were observed in 5% of patients. Our results show that there are no correlation between the disease duration and PFT findings, so asymptomatic patients with a variety of risk factors should be investigated further.

Source link: https://doi.org/10.18502/acta.v60i5.9557


The Effect of Chia Seed Extracts against Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats

The oxidation of chia seeds is usually nonexistent due to the presence of bioactive components, which have a large role in the food and pharmaceutical industries. The protective effects of chia seed extract against complete Freund's adjuvant rheumatoid arthritis in rats were studied with 100, 200, 300, and 400 ppm/kg BW rat/day chia seeds aqueous extract for four weeks. The findings revealed that chia seed extract contained high amounts of protein and total dietary fiber values of 21. 3 percent and 27. 24%, respectively. In vitro, Chia seed extracts were effective for the bioactive components such as phenolics, flavonoids, and anti-oxidant activity. The rat knee's health improvement was shown by histopathological testing, revealing that chia seed extract intake can reduce pathological changes in injured rheumatoid arthritis rats. paraphrased arthritis CFA-induced rats could have been reduced by chia seed extracts, according to it.

Source link: https://doi.org/10.1155/2022/3507674


Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice

In C57BL/6 wild type versus HLA-DR4 transgenic mice, we used an established model of organic dust extract exposure with and without collagen-induced arthritis to help with pathologic lung inflammation. Following an increase in ectopic lymphoid aggregates composed of T and B cells following ODE exposure in DR4 mice, Lung histopathology reported an elevated number of ectopic lymphoid aggregates composed of T and B cells. Similar elevated pro-inflammatory lung profiles in DR4 mice as a result of a dramatic rise in infiltrating lung CD4+ and CD8+ T cells, as well as CD19+CD11b+ autoimmune B cells, were accompanied by a dramatic rise in infiltrating lung CD4+ and CD8+ T cells, as well as CD19+CD11b+ autoimmune B cells. These results support a model in which environmental insults promote enhanced post-translational protein modification and lung inflammation in mice with RA-associated lung disease.

Source link: https://doi.org/10.1186/s12931-022-02085-8


Prediction Aided Tapering In rheumatoid arthritis patients treated with biOlogicals (PATIO): protocol for a randomized controlled trial

To minimize the chance of a flare during this process, we've previously designed and externally validated a flexible flare prediction system for use as a decision aid during stepwise tapering of bDMARDs. Methods This will be a bDMARD tapering trial that uses flare risk predictions from the investigator-initiated, multicenter, open-label controlled trial. Patients with a bDMARD with stable low disease prevalence will be recruited. In the case of a high risk of flare, the bDMARDARD will be tapered by an intervention group, where the next bDMARD tapering step is not taken in the event of a severe risk of flare. Both health care Utilization and Work Productivity will be assessed. Discussion This will be the first clinical trial to determine the benefits of using a dynamic flare prediction system as a decision aid during bDMARD tapering.

Source link: https://doi.org/10.1186/s13063-022-06471-x


Impact of continuity of care on risk for major osteoporotic fracture in patients with new onset rheumatoid arthritis

From the Korean National Health Insurance Service-Senior cohort website, a total of 8715 incident RA patients from 2004 to 2010 were included. For RA patients with poor COF that had poor COC, the incidence of MOF was higher in RA patients with bad cholesterol than in those with good COC. Patients with poor COC had an elevated risk of overall MOF, with the highest risk being forearm fracture. Patients with elevated MOF risk of poor COC were mainly observed in females. According to this report, interventions that can raise COC in patients with RA should be considered.

Source link: https://doi.org/10.1038/s41598-022-14368-7


Improved diagnosis of rheumatoid arthritis using an artificial neural network

Rheumatoid arthritis is a chronic systemic disease that can cause joint injury, autism, and chronic polyarthritis. However, RA diagnosis and diagnosis of RA can be difficult at the time of its disease onset due to overlapping signs with other arthritis, so early detection and diagnosis of RA aid in patient management. We used an artificial neural network as the training algorithm to analyze its results in order to improve the medical diagnosis of RA and determine the effects of various surgical conditions on RA diagnosis, as the training algorithm, and used fivefold cross-validation to measure its results. This ANN model assigned a probability for being either an RA patient or a non-RA patient based on the patient's location after training. Therefore, this ANN algorithm not only improved the accuracy of RA diagnosis, but also revealed that anti-CCP had the highest effect at all ages, while anti-CarP had the youngest effect on RA diagnosis.

Source link: https://doi.org/10.1038/s41598-022-13750-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions