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Rheumatoid Arthritis - Crossref

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Last Updated: 22 June 2022

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Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs

In DARWIN 3, a long-term, open-label extension study, a long-term, open-label extension study, the long-term safety and effectiveness of filgotinib, with or without methotrexate, was assessed for the care of patients with rheumatoid arthritis. Methods Eligible patients completing the 24-week DARWIN 1 and DARWIN 2 trials became eligible patients in DARWIN 3, where they received filgotinib 200 mg/day except for 15 men who were given filgotinib 100 mg/day. In the filgotinib monotherapy group, there were 3. 55 years in the filgotinib + MTX group and 3. 38 years in the filgotinib monotherapy group. According to the EAIR, the EAE was 3. 1 and 4. 3 respectively for significant TEAEs in the filgotinib + MTX group and 25. 8 in the filgotinib monotherapy group, with 24. 6 in the filgotinib monotherapy group and 25. 8 in the filgotinib monotherapy group.

Source link: https://doi.org/10.3899/jrheum.201183


Tuberculosis in Biologic-naïve Patients With Rheumatoid Arthritis: Risk Factors and Tuberculosis Characteristics

Methods We conducted a population-based case-control study using the Swedish Rheumatology Quality Register, the National Patient Register, and the Tuberculosis Register to identify RA patients with active TB and matched RA controls without TB from 2001-2014. The study included 31 RA patients with TB and 122 matched RA controls, enabling diagnosis and reporting. There were no significant differences between maximum dose of PSL, treatment duration with PSL before TB, or the cumulative dose of PSL before TB diagnosis between patients and controls. Obstructive pulmonary disease (TB) was correlated with an elevated risk of TB. Several RA-related factors can increase TB risk among biologic-nau00efve patients with RA, increasing the risk of TB activation in biologic-nau00efve patients with RA, making the risk of TB activation difficult to assess in the individual patient. The findings reveal that latent TB screening for TB screening in biologic-nau00efve patients could also be considered in order to reduce TB in patients with RA.

Source link: https://doi.org/10.3899/jrheum.201251


Meaningful Change Thresholds for Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue and Pain Interference Scores in Patients With Rheumatoid Arthritis

Methods The effectiveness of several patient-reported outcomes in the Arthritis, Rheumatism, and Aging Medical Information Systems cohorts was determined by 521 patients with RA. Baseline exhaustion and pain interference scores were near average, according to a u201d report. We estimated MCTs using the mean change in PROMIS scores for patients who rated their change as "significant" rather than others. Patients aged 6. 9% reported their exhaustion was a little better than normal, and 22. 8 percent a little worse. Pain was a little better for 11. 5% of patients but a little worse for 24. 2% of patients. Conclusion The group-level MCT for PROMIS Fatigue and Pain Interference is approximately 221 points and correlates to a small effect size, which is consistent with earlier research indicating an MCT of 2 points for PROMIS Physical Functioning.

Source link: https://doi.org/10.3899/jrheum.200990


Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning

Objectives - This paper examined the relationship between fibroblast growth factor -21, an adipokine linked to metabolic stress, and persistent longitudinal changes in body composition and physical fitness in patients with rheumatoid arthritis. Methods At baseline and follow-up patients with RA aged 18 to 19 years old achieved whole-body dual-energy X-ray absorptiometry and peripheral quantitative computed tomography to determine lean mass, fat mass, and muscle density. Using the Health Assessment Questionnaire and the Short Physical Performance Battery, Dynamometry measured muscle strength at the hand and knee, as well as physical fitness. Linear and logistic regression analyses showed connections between FGF-21 levels and both body composition and physical fitness over time, as well as physical fitness. FGF-21 values at higher baseline FGF-21 were correlated with muscle mass and area Z-scores worsening, as well as a greater likelihood of a clinically meaningful decline in HAQ. These results support the theory that FGF-21 can identify patients at risk of functional decline, according to these studies.

Source link: https://doi.org/10.3899/jrheum.200673


Impact of Comorbid Conditions on Healthcare Expenditure and Work-related Outcomes in Patients With Rheumatoid Arthritis

Objectivist goal In patients with rheumatoid arthritis, we were able to determine the effects of comorbid conditions on direct healthcare spending and work-related outcomes. Methods This is a retrospective review of the Medical Expenditure Panel Survey in the United States, from 2006 to 2015, there were 4967 adults with RA in the United States. Patients with heart disease and heart disease had the highest incremental annual healthcare expenditure per capita compared to those without the condition. HTN, depression, eye and adnexa disorders, or stroke was among the key factors affecting employed patients with RA. On average, HF patients with HF earned US$ 15,833 per year less than RA patients without HF. Conclusions Comorbid conditions in patients with RA were related to increased annual healthcare expenditures, lower likelihood of employment, higher rates of absenteeism, and lower income.

Source link: https://doi.org/10.3899/jrheum.200231


Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-world Data Analysis Using Machine Learning

In randomized controlled trials, Objective Tocilizumab has shown similar success when used as monotherapy as in conjunction with other drugs for rheumatoid arthritis. Using RCT results, we developed a remission prediction score for TCZ monotherapy and then ran an external validation of the prediction score using real-world data. Methods We found patients in the Corrona RA registry who used TCZM and matched the model and patients from four RCTs used in previous studies. Results The percentage of patients who experienced remission on TCZm by their follow-up visit was 12% compared to 15% in RCTs. All bDMARDm patients in the RWD in the RWD fitting the same logistic regression model led to a 0. 8 percent drop in the AUROC on held-out TCZm patients to 0. 72 percent.

Source link: https://doi.org/10.3899/jrheum.201626


Systematic Review and Metaanalysis of the Reproducibility of Patient Self-reported Joint Counts in Rheumatoid Arthritis

In comparison to trained clinicians, the goal was to determine the reproducibility of patient-reported tender and swollen joint counts in patients with rheumatoid arthritis. Methods We conducted a systematic literature review and metaanalysis of studies comparing patient-reported TJCs and/or SJCs in patients with RA patients with RA. TJCs were reduced for higher TJC values, which indicated a positive bias for self-reported TJCs, which was not present for SJCs. Patient-reported joint counts may be useful in annual examinations for patients in remission and monitoring treatment response for patients with RA.

Source link: https://doi.org/10.3899/jrheum.201439


Improved Incidence of Cardiovascular Disease in Patients With Incident Rheumatoid Arthritis in the 2000s: A Population-based Cohort Study

Methods We compared Olmsted County, Minnesota, residents with incident RA and non-RA samples from the same source population with similar age, sex, and calendar year of index. Results The study included 905 patients with RA and 904 non-RA patients, as well as 904 non-RA patients. The incidence of any CVD event in the 2000s compared to the 1980s was lower in patients with incident RA in the 2000s compared to the 1980s. Patients with RA in the 2000s had no increase in CVD relative to non-RA patients. In the 2000s vs. the 1980s, there were significantly lower rates of RA after a CVD event in the 1990s compared to 1980s and 0. 68 in the 2000s and 1980s. The current gap between patients with RA and the general population is closing. The incidence of CVD events in RA may be increasing.

Source link: https://doi.org/10.3899/jrheum.200842


Reliability and Change in Erosion Measurements by High-resolution Peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients

Using high-resolution peripheral quantitative computed tomography, the aim of this multireader experiment was to investigate the accuracy and change of erosion measurements in patients with rheumatoid arthritis patients with high-resolution peripheral quantitative computed tomography. The scannings of 23 patients with RA were performed at baseline and 12 months, according to baseline and 12 months. The dorsal, palmar, radial, and ulnar surfaces of the metacarpal head and phalangeal base of the second and third digits were investigated by four distinguished readers, blinded to time order. Per timepoint, 368 surfaces were evaluated to identify cortical fractures as pathological or physiological, as well as estimating erosion width and depth, as well as measuring erosion width and depth. Most physiological cortical breaks were found at the palmar PB, while the bulk of pathological cortical breaks were found at the radial MH. HR-pQCT erosion measurements were reliable and capable of detecting change over time, according to this research.

Source link: https://doi.org/10.3899/jrheum.191391


Higher Prevalence and Degree of Insulin Resistance in Patients With Rheumatoid Arthritis Than in Patients With Systemic Lupus Erythematosus

In both populations, a multivariable regression analysis was used to determine the difference in IR indexes between patients with SLE and RA, as well as determining whether IR risk factors or disease-related characteristics are causally associated with IR in both populations. Following multivariable testing, the insulin:C-peptide molar ratio in patients with RA was upregulated in patients with RA compared to patients with SLE. After multivariable testing, HOMA2 indexes related to insulin tolerance were found to be lower, while u03b2 cell function demonstrated higher IR indexes in RA than in SLE patients. Patients with RA more often fulfilled the definition of IR than those with SLE. In RA than in SLE patients, IR sensitivity is lower and u03b2 cell function is higher. In both SLE and RA, traditional IR factors have an equal effect on IR in both SLE and RA, backing up the assertion that these differences are due to the diseases themselves.

Source link: https://doi.org/10.3899/jrheum.200435

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions