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Rheumatoid Arthritis - Astrophysics Data System

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Last Updated: 22 May 2022

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A Sub-pixel Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis

Rheumatoid arthritis is a chronic autoimmune disease that predominantly affects peripheral synovial joints such as fingers, wrist, and feet. With universal spatial resolution, limited by the current spatial resolution of radiographic images, joint space narrowing of RA for the same reason as above can be less than one pixel per year for universal spatial resolution. Our study assesses JSN evolution between a baseline and its follow-up finger joint images by using the frequency spectrum in the frequency domain. The mean error can be reduced to 0. 0130mm when applied to phantom radiographs with ground truth, and to a 0. 0519mm standard deviation for clinical radiography, using this research.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220509315O/abstract


Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility

MHC class II molecules transfer IgG heavy chain to the cell surface. We found that MHC class II molecules transferred IgG heavy chain to the cell surface. Certain MHC class II alleles, including some autoantibody binding to an IgG heavy chain complexed with various MHC class II alleles, was strongly associated with rheumatoid arthritis susceptibility conferred by several MHC class II alleles.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111.3787J/abstract


Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis

The role of complement activation in response to therapy is limited, as well as the emergence of premature CVD in RA. We also investigated the correlations between TCC and inflammatory and cardiovascular biomarkers, using soluble terminal complement complex levels in RA. Methods We analyzed 64 RA patients beginning with MTX monotherapy or TNFi, with or without MTX co-medication. TCC was 1. 10 CAU/mL, and 57 patients had TCC higher than the estimated upper reference limit - as shown by the results Median TCC was 1. 10 CAU/mL, with 57 patients having TCC above the estimated upper reference limit 57. Patients with endothelial disease had elevated baseline TCC compared to those without. Patients with active RA had elevated TCC, indicating greater complement activation. TCC reduced with antirheumatic therapy even after 6 weeks, and after 6 weeks, TCC was down with antirheumatic therapy. Among patients with endothelial dysfunction in RA had higher baseline TCC than those without, indicating an involvement of complement in the atherosclerotic process in RA.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1764628N/abstract


Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis

However, an immediate functional response of immune cells from ACPA + RA patients toward citrullinated proteins has not been demonstrated. In addition, serum from ACPA+ RA patients expressing human Fc receptor cells may be able to stimulate human Fc expressing rat basophil cells, enabling activation by citrullinated proteins. In comparison to ACPA RA and osteoarthritis patients, Mast cell degranulation agents such as histamine were boosted in synovial fluid of ACPA + RA patients, as well as osteoarthritis patients. An increased number of degranulated CD117 + mast cells in ACPA+ RA patients was found in synovial biopsies, according to IgE and FcRI expression in synovial mast cells from ACPA + RA patients. Our results in conclusion demonstrate an immunological response of immune cells from ACPA + RA patients in a citrulline-specific manner.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107.2586S/abstract


Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling

However, HENECA partially blocked TNF-evoked MMP-3 production, while Stimulation with TNF accelerated the release of MMP-3 from MH7A cells. HENECA's activation of A 2A AdoR signaling alone using HENECA did not reduce TNF-induced MMP-3 production to the previous high, but does not eliminate serum MMP-3.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.6033K/abstract


Exhaled nitric oxide in early rheumatoid arthritis and effects of methotrexate treatment

The aim of the present study was to investigate the NO lung dynamics in patients with new onset RA before and after immune suppression with methotrexate therapy. C A NO was lower in RA patients 1. 6 ppb compared to the control group's 2. 3 ppb, p = 0. 007. According to C aw NO, the RA patients' 55 ppb was also lower than the control group's 124 ppb, p 0. 001, but D aw NO was also higher 17 mL/s and 9 mL/s respectively, p 0. 001. In conclusion, the modified NO dynamics of the lung in ACPA-positive RA patients are still present in the early stages of the disease before any medications and do not change after methotrexate therapy, which has been shown to have a role in the pathogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.6489W/abstract


Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation

However, little is known about the active ingredients and pharmacological mechanisms that mediate P. sinensis's reaction against RA. Q Exact Focus mass spectrometer analyzed the compounds present in P. sinensis. The active constituents and pharmacological mechanism of P. sinensis against RA were lucidified through a network pharmacology-based study. To further investigate the mechanism of P. sinensis against RA, a collagen-induced arthritis model was used. P. sinensis against RA was evaluated using network pharmacology, five chemicals, twenty-five goals, and eight pathways were identified. Experimental results showed that P. sinensis extract and five compounds could prevent the release of inflammatory mediators in LPS-induced RAW 264. 7 cells. Conclusions P. sinensis' versus RA's is based on the research. Our findings may lead to the development of P. sinensis into a substitute for Erycibes Caulis.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1764786H/abstract


Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis

Although there are evidences pointing to the presence of anti-citrullinated peptide antibodies in human saliva, no studies have reported citrullinated peptide detection in human saliva. Saliva samples were obtained from 11 patients with RA and 20 healthy people. The citrullinated CK13 ratio was calculated using the AMC antibody's band yielded by the anti-CK13 antibody's band. There was no significant difference between the salivary Cit-CK13 ratios of patients with RA and healthy volunteers compared to healthy controls. This is the first study to show that Cit-CK13 is present in human saliva, and that there is no significant difference between patients with RA and healthy controls, indicating that salivary Cit-CK13 content and RA development may not be related.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765687Y/abstract


A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population

CZP accelerated disease symptoms in approximately half of patients in a clinical trial of patients with severe RA. However, variability in CZP effectiveness persists as a barrier for clinicians, and the aim of this research was to find genetic variants predictive of CZP response. In the REALISTIC trial to find common single nucleotide polymorphisms related to treatment response, we performed a genome-wide association study of 302 RA patients treated with CZP. Whole-exome sequencing was also performed for 74 CZP extreme responders and non-responders within the same community, as well as 1546 population controls.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1761165W/abstract


Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritis

The IL-32-specific exon was excluded from the IL-32-specific exon in vitro and vivo, primarily leading to the expression of IL-32-32 mRNA and protein, mainly leading to the production of IL-32 mRNA and protein in vitro and protein. Compared to IL-32, overexpression of splice-resistant IL-32 in THP1 cells or rheumatoid arthritis synovial fibroblasts resulted in the greater induction of proinflammatory cytokines such as IL-1. Overexpression of mainly IL-32 in RA synovial fibroblasts showed minimal concealment and reduced cytokine production. In contrast, overexpression of splice-resistant IL-32 in RA synovial fibroblasts revealed a dramatic increase in IL-32 in RNA synovial fibroblasts, which was not revealed. In RA, we observed an elevated IL-32 expression relative to osteoarthritis synovial tissue. In addition, TNF and IL-6 expression in RA correlated strongly with IL-32 expression in RA, although this was not observed for IL-32. IL-3221 is a safety switch in limiting the effects of IL-32 and reducing chronic inflammation.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..108.4962H/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions