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We find that telomerase reverse transcriptase expression is closely related to immunosuppressive signatures when using single-sample gene set enrichment analysis of 9,264 tumor samples. In addition, we show that TERT-initiated ERV/interferon signaling increases the expression of chemokines, including CXCL10, which leads to the infiltration of suppressive T-cell populations with an elevated number of CD4+ and FOXP3+ cells.
Comprehensive genome-wide maps of regulatory elements that support cellular immune responses and autoimmune disorders have been produced by Epigenomic studies profiling immune cells, which may be crucial to deciphering the regulatory networks that underlie cellular immune responses and autoimmune disorders. Endogenous retroviruses have been found in these genomic maps as unexpected ally in human immune system regulation. Here, we explore how endogenous retroviruses have given rise to a variety of policy variables that influence host immune responses' epigenetic landscapes.
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