Retrovirus - Springer Nature

Clinical significance of human endogenous retrovirus K (HERV-K) in multiple myeloma progression

Retrotransposons retroviruses that infect human germline cells and account for 58% of the human genome and account for 5u20138% of the human genome. We found that the HERV-K envelope and long-term repeat expression were statistically higher inside plasma cells in MM than in monoclonal gammopathy of unknown importance or controls. In the MM. 1S cell line, the HERV-K env knockdown increased proliferation and reduced the expression of the tumor suppressor genes TP53 and CDKN1A. Clarifying the role of HERV-K in MM will result in novel treatment approaches and provide new insight into MM pathogenesis.

Source link: https://doi.org/10.1007/s12185-022-03513-7

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