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Purpose: With the presence of subhyaloid hypopyons, we discuss one case of syphilitic necrotizing retinitis and one case of suspected syphilitic necrotizing retinitis. Case description We describe two cases of necrotizing retinitis, which were discovered to have yellow boat-shaped lesions along the inferior edge of retinitis resembling subhyaloid hypopyon. We may have to think about it as a case of suspected syphilitic retinitis as piperacillin is useful against Pseudomonas and the use of piperacillin in the management of syphilis is yet to be determined. Severe infection and necrosis restricted to the inner retina causes white blood cells and necrotic tissue in the subhyaloid space and will settle down, resulting in subhyaloid hypopyon. Two instances of subhyaloid hypopyon in literature and two cases reported in our book are syphilitic retinitis, which is not reported in other countries and is not reported in other countries.
Source link: https://europepmc.org/article/MED/36131541
To publish the fundus photographs and spectral domain optical coherence tomography findings of a patient with subacute sclerosing panencephalitis with merely ocular signs. A yellow lesion was visible in the macula and SD-OCT increased visibility of the inner retinal layers in the Fundus photograph. On the day the patient died, Fundus photographs revealed macular atrophy for both eyes. This case report details the SD-OCT results of SSPE retinitis with a close follow-up from acute retinitis to the total atrophic macula.
Source link: https://europepmc.org/article/MED/36122304
In a Chinese family, male patients and female owners of X-linked retinitis pigmentosa show potential mutations and help clarify the clinical findings. Genomic DNA was extracted from peripheral blood, and target fragments were amplified by PCR and sequencing specifically, and then sequenced. Among the female carriers, half of those who have poor visual acuity suffered with esotropia or exotropia. A novel mutation of the RPGR gene has been identified in this research, which broadens the spectrum of RPGR mutations, and expands the relationship between genotype and phenotype.
Source link: https://europepmc.org/article/MED/36124184
We identified a missense variation in CNGA1 that affects the cyclic nucleotide binding domain in an Indian family suffering from retinitis pigmentosa, and characterized a mouse model that was mutated CNBD in a Indian family suffering from retinitis pigmentosa. A gene panel analysis of 105 known RP genes was used to analyze a family with autosomal-recessive retinitis pigmentosa, revealing that CNGA1 was affected. This research supports a role for CNGA1 as a disease gene for arRP, as well as new insights into CNGA1-RP's pathobiology.
Source link: https://europepmc.org/article/MED/36115851
ABSTRACT Retinal degeneration is one of the most common causes of blindness worldwide, and no effective treatment has yet to be found. Visual restoration in advanced stage Retinitis pigmentosa has been investigated for visual enhancement, but lack of implant flexibility and foreign-object reactions have limited their use. Organic photoactive retinal prostheses can exceed these limitations by being biomimetic and tissue friendly. Overall, the findings reveal that graphene-enhanced organic photovoltaic units can be used to treat retinal dystrophies and aid in the translation of the organic strategy into medical practice. In the absence of strong inflammatory responses, implanted dystrophic rats restored visual appearances at both subcortical and cortical levels in reaction to light stimulation.
Source link: https://europepmc.org/article/PPR/PPR546462
Introduction: An inflammatory process that occurs in Retinitis pigmentosa-affected eyes can be described in literature. Uveitis can develop independently of RP, and it's important to distinguish real uveitis from inflammatory manifestations of RP. The trial included 7 RP patients with coexisting uveitis signs. 7 patients in the Royal Uveitis Group had signs of intermediate uveitis, and 3 of them had signs of minimal anterior uveitis. In the most recent analysis, only one patient was diagnosed with RP and uveitis simultaneously. Patients had vitreous cells 1 + or 2+, as well as vitreous haze 0,5 + or 1+ in addition to the traditional picture of RP. Despite sex, absence of acute onset of uveitis, and systemic complaints, the feasibility of the HLA-B27 association should be considered in RP patients with anterior and intermediate uveitis signs in RP patients with anterior and intermediate uveitis signs, according to sex, absence of acute onset of uveitic infections, and systemic complaints. In RP patients with inflammation-related diseases, anti-inflammatory therapy is required.
Source link: https://europepmc.org/article/PPR/PPR545590
Retinitis pigmentosa is the most common retinal hereditary dystrophy and result in blindness as time progresses. To determine if RP significantly raised the risk of PACG formation, we conducted a population-based analysis. Methods used by the Taiwan National Health Insurance Research Database, we recruited patients with RP into the RP program from 2001 to 2013 and included a comparison group of 1:4 age-and-sex-matched individuals with no RP. Result We enrolled 6223 people with RP and 24892 subjects for comparison. The cumulative incidence of PACG in patients with RP was 1. 6 percent, which was significantly higher than that in the comparison group. People with RP are at a significantly higher risk of developing PACG than those without RP, according to a national population-based cohort study.
Source link: https://europepmc.org/article/MED/36083972
Patients'u2019 poor and often unpredictable responses are often difficult to assess treatment options and determining treatment outcomes, but evaluating visual function in advanced low vision patients is often difficult due to patients' poor and often delayed responses. Design by spectral-domain OCT. Design & Analysis of Visual Function Tests In 84 eyes of 43 patients with visual acuity of 0. 01 or lower, combined with retinal structural features, as determined by spectral-domain OCT. Objectives Objectivity Design This study was designed to specifically assess visual function and disease stage in RP patients with visual acuity of 0. 01 or lower, as determined by spectral-domain OCT. Conclusions The combination of pupillometry and FST allowed for grading of visual appearance in patients grouped in the same visual acuity groups in advanced RP patients with ultra-low vision.
Source link: https://europepmc.org/article/PPR/PPR541903
We discuss a fourth identified patient with genomic mutations in the EXOSC2 gene, which code for a cap protein in the RNA exosome. A in exon 6 and a heterozygous paternal variant, splice donor NM_014285. 6: A in intron 8 generated two mutations of uncertain clinical significance, including: a heterozygous maternal variant, missense mutation NM_014285. 7: A in exon 6 and a heterozygous paternal variant, splice donor NM_014285. 7: A in intron 8; c. 801G > A in c1G > A in a ma a h a h he o gous paternal variant CM_014 a chromos of unknown clinical significance, cia in RNA c427G > A in intron 8 e donor NM_01427G> A in h CM_01427.
Source link: https://europepmc.org/article/MED/36069504
Introduction Cataract extraction may improve visual acuity for patients with retinitis pigmentosa, while the surgery may exacerbate photoreceptor degeneration due to light damage. We conducted a systematic review and meta-analysis to investigate the benefits and prediction of VA after cataract surgery in patients with RP. The preoperative macular ellipsoid zone in patients with RP was compared to that of cataract surgery in different durations of follow-up and different structural integrity of the preoperative macular ellipsoid zone. In preoperative and postoperative VA, there were significant differences between EZ-abnormal and EZ-normal groups, with MDs ranging from 0. 56 to 0. 46. Conclusions Cataract surgery may be able to boost VA for patients with RP during long-term follow-up, and it is not appropriate for patients with invisible preoperative macular EZ. However, further research is required to address the issue of excessive light exposure to the degenerated retina in patients with RP with cataract surgery.
Source link: https://europepmc.org/article/MED/36057888
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