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We reviewed medical records of 121 patients/235 eyes of typical retinitis pigmentosa patients who were expected to be followed for at least five years with the intention of finding the long-term course of visual function development at each RP stage and appropriate assessment methods. The moderate RP group had a quicker progression than other groups in MD. The moderate and late RP groups in S4 had faster growth than the mild RP group. The late RP group in Virginia had faster growth than the other groups. The autosomal dominant and autosomal recessive groups had a slower growth than the sporadic group in MD; the autosomal dominant and autosomal recessive groups had a slower VA decline than the sporadic group. Since the conversion rates of VA and visual field test differed as part of the RP process, S4 and VA can also be effective assessment techniques depending on the time.
Source link: https://doi.org/10.1155/2022/7204954
Purpose The objective quantification of visual function in patients with advanced retinitis pigmentosa is a difficult problem because of poor visual functioning in these patients. Patients with RP and ten healthy controls were enrolled in MRI examinations. Methods and MethodsThis research used magnetic resonance imaging to determine the function and structure of the visual cortex in patients with RP and quantitatively classify them. In the ipsilateral V1 pathway in the flash task, the FP and NFP groups had significantly lower values in several pathways than the HCs, and FC in the ipsilateral V1 pathway was significantly lower in the FP group than in the FP group. In both flash and pattern visual tasks, a positive relationship between response intensity and GMV was found in Brodmann areas 17, 18, 19 and 19. ConclusionMagnetic resonance imaging was an effective way to objectively and quantitatively assess patient visual performance in patients with advanced RP.
Source link: https://doi.org/10.3389/fnagi.2022.825204
Patients with retinitis pigmentosa are expected to have a primary angle-closure disease in patients with primary angle-closure disease. This was a retrospective review of all RP patients over the course of ten years in the Genetics Eye Clinic of a tertiary-care hospital during a 7-year period. Patients with a shallow anterior chamber, high IOP, or glaucomatous optic discs were referred to the glaucoma department, where they underwent further IOP testing, a gonioscopy, and disc examination by a glaucoma specialist. Results: During the study period, 618 RP patients were examined, of whom 91% had normal RP, with 91% having typical RP. Primary angle-closure glaucoma was 2. 7 percent, with primary angle closure being 2. 9%, primary angle closure being 0. 65%, and primary angle-closure glaucoma at 2. 8 percent. Conclusion: The prevalence of PAGC in RP patients over 40 years was higher than in the general population of a similar age.
Source link: https://doi.org/10.4103/ijo.IJO_3189_21
Retinitis pigmentosa is one of a group of pigmentary retinopathies. It is the most common inherited retinal dystrophy, characterized by photoreceptor degeneration that leads to nyctalopia and ultimately complete vision loss. The continuous retinal degeneration that progresses from the mid-periphery to the central and peripheral retina. It is one of the leading causes of bilateral blindness in adults, with a prevalence of 1 in 3000 people around the world. Although over 90 genes have been identified in RP patients, approximately half of RP patients' cases's RP patients' causal factors remain unknown.
Source link: https://doi.org/10.4103/ijo.IJO_46_22
In a tertiary care clinic in a developing world, a study will investigate the toxicity of valganciclovir in cytomegalovirus retinitis in human immunodeficiency virus (positive) patients. Methods: HIV patients with CMVR and undergoing treatment with valganciclovir were analyzed in a retrospective study. Out of nine patients who were included, two patients developed CMVR in the other eye, and only one patient sustained retinal detachment during the course of the study. Conclusion: Oral valganciclovir used in the literature gave promising results, and it was discovered to be a more effective alternative to the use of intravitreal ganciclovir.
Source link: https://doi.org/10.4103/ijo.IJO_2787_21
U2013Biedl syndrome patients in Laurence were surveyed in terms of clinical diagnosis and population of retinitis pigmentosa. Methods: This is a cross-sectional observational hospital-based research in which 244 patients with a RP in LMBB syndrome presenting to our hospital network between March 2012 and October 2020 were included in this cross-sectional observational research. At presentation, all 244 patients complained of blurred central vision. In both patients, the most notable retinal feature at presentation was diffuse or widespread retinal pigment epithelial degeneration. Patients with a RP in LMBB syndrome are mainly in the first to second decade of life, with significant visual acuity impairment to blindness early in life. In an early-onset RP with central visual acuity loss, it is vital to rule out LMBB syndrome. On the other hand, all patients diagnosed or suspected with LMBB syndrome systemic signs at a physician clinic should be referred to ophthalmic inspection, low vision assessment, rehabilitation, and vice versa.
Source link: https://doi.org/10.4103/ijo.IJO_2268_21
To describe the clinical presentation and ethnic distribution of retinitis pigmentosa in patients with Usher syndrome. In total, 401 patients with a medical diagnosis of USH and RP in at least one eye were included as patients in at least one eye. Defective night vision was the most common presenting feature in all forms of USH type 1: 43, type 2: 68, and type 3: 40, followed by poor peripheral vision. Patients with type 2 USH had more eyes with severe visual impairment. RP in USH is typically bilateral, and it mostly affects males of all subtypes. Patients with USH and RP will have more affinity for peripheral vision than central vision. Early visual and hearing health in USH patients with prompt referral to ophthalmologists and vice versa is the most important finding of our study.
Source link: https://doi.org/10.4103/ijo.IJO_2272_21
Retinitis pigmentosa is the most common retinal hereditary dystrophy, which can lead to blindness if it progresses. Patients with RP have a significantly elevated risk of OAG formation, according to our researchers. We enrolled patients with RP into the RP database in Taiwan, China, from 2001 to 2013; we also included a comparison group of 1 : 4 age- and gender-matched individuals without RP; and 1 : 4 age- and gender-matched individuals without RP. The cumulative incidence of OAG in patients with RP was 1. 7%, significantly higher than in the comparison group. The risk of OAG growth in the RP group was significantly higher than in the comparison group with unadjusted HR of 2. 86. According to this nationwide population-based cohort study, people with a RP are at a significantly higher risk of developing OAG than those without it.
Source link: https://doi.org/10.1155/2022/9719095
BACKGROUND OBJECTIVE oedema in patients receiving allogeneic haematopoietic stem cell transplantation. Case description A 44-year-old male patient suffered vision loss in his left eye eight months after allogeneic stem cell transplantation. A posterior retinopathy with retinal swelling, a yellow necrotic border, and a vascular white sheath were present in the superior temporal retina but not the posterior pole in the ophthalmologic examination. The patient's macular oedema gradually decreased and disappeared completely by the second week, according to daily OCT reports, and his left eye vision partially improved. Conclusions Macular oedema can be present in patients with cytomegalovirus retinitis, but it is rare during therapy. Patients with cytomegalovirus retinitis receiving vitreous cavity injections of ganciclovir need to be investigated and discussed in order to further investigate and discuss.
Source link: https://doi.org/10.1186/s12886-022-02500-0
1Market Access, London, England, UK; 2Market Access, 2Market Access, Lightning Health, 1 Andrew Satherley, 12. 6 million images; 1 market access, Newcastle Health, 15 Matthew Matthew, 1 Matthew Jefferson, 1 Andrew Satherley,1 Matthew Zegaoui,1 Luigi A. 4, London, England, United Kingdom; 2Market Access, 2Market Access, 2Market Access, HEART; 5381918748, Phone number: 2Market Access, London, England, Scotland, &apose, e, 3 & —1E1-33, 2Market Access, 2The leading cause of visual impairment, 2Market Access, 1A, London, 2E9cile deb1; 2Market Access, 2E9cile, 1A1 Andrew Zegaoui, 1Retin, 2Tamp; 1 1; 1YZegaoui, 1; 2E4; 2Market Access, 2E9Chat, UK; 2Market Access, Matthew; & 2XL;4A; & &, 11 & t; 2Market Access; A literature search of publicly available information on all aspects of RP; a systematic literature review using Medline, Embase, the Cochrane Library, and grey literature on epidemiology and cost of RP; and qualitative research with senior physicians in the EU4 and the UK to validate research findings from secondary sources were carried out in three stages. RP has a major effect on over a million people's everyday lives around the world. Progressive vision loss has a huge effect on the ability to do regular daily activities, to hold jobs, and maintain independence. Consequently, most patients will have reduced quality of life, with greater emotional and psychological implications than those related to vision loss such as diabetic retinopathy or age-related macular degeneration. A high rate of caregiver burden is also associated with a high degree of carer distress, both psychological and financial difficulties. Although disease prevention can be helpful in devising coping techniques, the majority of patients live with this chronic, progressive disease state with no intervention to change the disease course.
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