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Purpose Among the articles are focused on a single case of syphilitic necrotizing retinitis and one case of suspected syphilitic necrotizing retinitis with the presence of subhyaloid hypopyons. We report two cases of necrotizing retinitis, which were discovered to have yellow boat-shaped lesions at the inferior edge of retinitis resembling subhyaloid hypopyon. We may have to consider this case of suspected syphilitic retinitis as piperacillin is safe against Pseudomonas and as piperacillin's use in the management of syphilis is not researched. Severe infection and necrosis restricted to the inner retina leads to the accumulation of white blood cells and necrotic tissue in the subhyaloid space and would settle down resulting in subhyaloid hypopyon. In literature, two cases of subhyaloid hypopyon found in literature and two cases illustrated in our paper are syphilitic retinitis, which is not reported in other countries.
Source link: https://doi.org/10.1177/11206721221126296
AIM: To demonstrate the clinical characteristics, risk factors, the clinical diagnosis, and the recurrence of cytomegalovirus retinitis in HIV-negative patients. METHODS: The study involved HIV-negative patients with CMVR were included. At last visit, the mean logMAR BCVA increased from 0. 94. 98 originally to 0. 77. 73, but not significantly. The aqueous CMV DNA load has significantly decreased to 7102 copies/mL after antiviral therapy, as opposed to baselineu00d7105 copies/mL. The poor visual prognosis was largely linked to Macular involvement and early visual acuity. The number of retinal lesions was highly associated with the likelihood of recurrence of CMVR. Visual prognosis is heavily associated with Macular involvement and early visual acuity. The presence of retinal lesions is strongly linked to CMVR's recurrence. These ocular characteristics can be used as predictive risk factors for long-term visual prognosis in HIV-negative CMVR patients.
Source link: https://doi.org/10.18240/ijo.2022.10.11
Although rats with melanin-pigmentated retinal pigment epithelial cells are biologically more suitable models for human eye research than their albino counterparts, reliable models from the former strain are not available to investigate retinal degeneration. The LE rat was back-crossed over 5 generations to produce the colored LE Pde6b KO strain from the Pde6b-knockout Sprague 2014Dawley rats with the CRISPR-Cpf1 device after the generation of the Pde6b-knockout Sprague Spragueu2013Dawley rats with the CRISPR-Cpf1 unit over five generations. Interestingly, LE Pde6b KO had well-developed bone-spicule pigmentation, a hallmark of fundus in patients with RP that can not be observed in non-pigmented albino rats.
Source link: https://doi.org/10.3389/fmed.2022.909182
ABSTRACT Retinal degeneration is one of the most common causes of blindness worldwide, for which no appropriate therapy has yet to be found. In advanced stage Retinitis pigmentosa, photographic reconstruction has been attempted for visual recovery, but a lack of implant flexibility and foreign-object reactions have limited their use. A flexible substrate was recently engineered based on a dual poly-3-hexylthiophene and graphene layer inspired by organic photovoltaic techniques involving graphene. In the absence of marked inflammatory responses, implanted dystrophic rats' visual results improved visual responses at both subcortical and cortical levels in reaction to light stimulation. Overall, the findings show that graphene-enhanced organic photovoltaic devices can be used for retinal dystrophies repair and medical translation, as well as improving medical practice's translation of the organic theory.
Source link: https://doi.org/10.1101/2022.09.14.507903
Inherited retinal dystrophies are a clinically and genetically heterogeneous group of disorders with more than 250 causative genes. Vision loss is common in vision impairment for which there is no universal cure. Encouragingly, a first gene supplementation therapy for an autosomal recessive IRD has been approved. However, gene supplementation therapy for autosomal dominant IRDs isn't always relevant, because haploinsufficiency is not the only cause. Genome editing could be used to invalidate both alleles as well as supplementation of the wild type gene, specifically invalidating the mutant allele, with or without gene supplementation, or to correct the mutant allele.
Source link: https://doi.org/10.3390/ijms20102542
Recurrent mistute pigmentosa syndrome, also known as autosomal dominant retinal disease, occurs in 1%–u20132% of cases with nuclear Receptor Subfamily 2 Group E Member 3, p. or G56R, a common, genetically heterogeneous retinal disease. Both the frequency and DNE of G56R make it an intriguing target for allele-specific knock-down of the mutant allele using antisense oligonucleotides, an emerging therapeutic strategy for IRD. Next, we overexpressed wild type or mutant NR2E3 in RPE-1 cells, which was followed by AON therapy. WT and mutant NR2E3's transcript and protein levels were determined by reverse transcription quantitative polymerase chain reaction and Western blot respectively. In conclusion, we present the first proof-of-concept for AON-mediated silencing of a single nucleotide variant with a dominant negative result as a therapeutic strategy for NR2E3-associated adRP.
Source link: https://doi.org/10.3390/genes10050363
Abstract Retinitis Pigmentosa is a group of progressive retinal dystrophies that may be present clinically as part of a syndromic unit or as a single occurrence. We re-derived a mutant with a Cnga1 mutation from sperm samples of ENU mutagenesis derived F1 mice. From 8 weeks ago, Homozygous Cga1 mice carrying a c. 1526 A > G mutation suffered progressive degeneration in the retinal photoreceptors. CNGA1 as a disease gene for arRP is included in this study, which also provides new insight into the pathobiology of cGMP-binding domain mutations in CNGA1 -RP.
Source link: https://doi.org/10.1038/s41420-022-01185-0
Grassing is often inaccurate and sometimes unpredictable responses in advanced low vision patients are difficult to determine treatment options and evaluate treatment outcomes, but, grading of visual function in advanced low vision patients is often difficult due to patients' poor and sometimes unpredictable responses. FST, BCVA, and OCT assessed eighty-four eyes of 43 patients with advanced RP with visual acuity of 0. 01 and lower as a result of chromatic pupillometry, FST, OCT, and OCT. At the CF/HM VA range, central retinal thickness was not correlated with central retinal thickness and appeared to reflect overall remaining photoreceptor function, including peripheral retina. Conclusions The combination of pupillometry and FST provided a quantitative assessment of visual appearance in patients grouped in the same visual acuity groups in advanced RP patients with ultra-low vision.
Source link: https://doi.org/10.1101/2022.09.09.22279766
Retinitis pigmentosa is the most common cause of vision loss and blindness worldwide, with few surgical treatments available. We used retinal organoids and retinal pigment epithelium cells from induced pluripotent stem cells of a RP patient to create a cost-effective in vitro RP disease model in this research. ROs with USH2A mutations can lead to apoptosis of ROs with USH2A mutations via the PI3K-Akt pathway, according to transcriptomics and proteomics results. These results show the capability of a microfluidic chip as well as ROS methods in disease modeling for RP.
Source link: https://doi.org/10.3389/fbioe.2022.939774
Uveitis can develop independently of RP, and it's critical to distinguish true uveitis from inflammatory manifestations of RP. The trial included 7 RP patients with coexisting uveitis signs. 7 patients in 173 RP patients had signs of intermediate uveitis, and 3 of them had signs of slight anterior uveitis, and 3 of them had signs of mild anterior uveitis. In the current analysis, only one patient was confirmed with RP and uveitis simultaneously. Patients were vitreous cells 1 + or 2+, and for vitreous haze 0,5 + or 1+ in comparison to the classic picture of RP. Other instances were classified as HLA-B27 positive uveitis following an appointment with a rheumatologist and a patient with ankylosing spondylitis of low blood flow. Despite sex, absence of acute onset of uveitic complaints and systemic complaints, the possibility of HLA-B27 association in RP patients with anterior and intermediate uveitis signs should be considered in RP patients with anterior and intermediate uveitis signs. In RP patients with inflammation signs, anti-inflammatory therapy is required.
Source link: https://doi.org/10.21203/rs.3.rs-2054350/v1
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