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The authors investigate the case of a five-year-old boy who was born with a low fever and a mildly itchy skin rash. The exanthema travelled to the face and to the latero-cervical and retro-auricular regions of the country the day after the exanthema spread to the face and into the latero-cervical and retro-auricular areas. Following two days the lesions took on a purpuric hue and the so-called "yellow hand sign" appeared. The authors discuss a variety of disorders involving other skin rashes of childhood.
Source link: https://doi.org/10.1007/978-3-030-89089-6_8
Methods The presence of an anti-HMGCR antibody in the serum of 227 patients with idiopathic inflammatory myopathy and 100 healthy control patients was determined by ELISA. The clinical results, muscle pathological signs, and treatment of patients with anti-HMGCR myopathy, as well as comparisons between anti-HMGCR myopathy with and without dermatomyositis -like skin rashes – were analyzed among MSA-based subgroups. These patients' muscle biopsies revealed variable muscle tone and T cell infiltration, as shown by the muscle biopsies. Compared to those without DM-like rashes and shorter disease duration, anti-HMGCR myopathy patients with DM-like rashes had DM-like rashes on their rash, rather than those without DM-like rashes. In patients with anti-HMGCR myopathy, DM-like skin rashes and lymphocytic infiltrates were not common. Although anti-HMGCR myopathy may mimic DM-like rash, this is not pathologically different from classic DM and should be treated as a distinct subgroup of the IIM.
Source link: https://doi.org/10.1007/s00415-021-10621-7
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