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"Background Women with a history of chest irradiation for Hodgkin lymphoma are at a greater risk of developing bilateral breast cancer in this group, but contralateral breast cancer risk estimates in this population are undetermined. Methods We searched the SEER website for women treated with radiation therapy for Hodgkin lymphoma before age 30 years and were diagnosed with a new breast cancer diagnosis in 1990u20132016. The study included 295 women with a median age of 22 years at Hodgkin lymphoma diagnosis and 42 years at breast cancer diagnosis. A 40. 5% bilateral mastectomy rate was reported in a subgroup review of mastectomy patients, which revealed a 40 percent overall mastectomy rate. Women with a history of chest radiotherapy for Hodgkin lymphoma with a diagnosis of breast cancer have a 10-year contralateral breast cancer risk of 20%. ".
Source link: https://doi.org/10.1245/s10434-022-11947-w
"Surgical resection remains the keystone of meningioma therapy and represents the definitive treatment for the majority of patients; however, grade 2 and grade 3 meningiomas have more aggressive behavior and are impossible to treat. Several retrospective studies have shown the effectiveness and safety of postoperative adjuvant external beam radiation therapy for patients with atypical and anaplastic meningiomas. The timing of radiation therapy in patients with completely recovered atypical meningiomas, the most effective radiation technique, dose and fractionation, and treatment planning/target delineation are among the controversial topics.
Source link: https://doi.org/10.1007/s10143-022-01806-3
"Purpose" is the term used to describe a specific surface-guided stereotherapy intervention procedure with open-face mask immobilization and review the first clinical success in improving setup accuracy. Methods and materials The study of 48 SRT patients with head lesions was retrospectively reviewed. Patients initial setup was guided by 6DoF real-time deltas using the reference surface obtained from the skin contour delineated on the planning CT images. 0. 4 mm in VRT, 0. 1 mm in LNG, 0. 2 mm in LAT, 0. 1 degree in YAW, 0. 2 degree in PITCH, and 0. 1 degree in ROLL were among the final measurements of median CBCT couch shifts. "The proposed surface guided SRT therapy with open-face mask immobilization is a step forward in improving patient satisfaction and positioning accuracy in the same procedure. ".
Source link: https://doi.org/10.1186/s13014-022-02077-4
"Purpose Breast-conserving surgery followed by whole breast radiation therapy or total mastectomy without WBRT is the primary therapy for early stage breast cancer patients," the spokesperson says. Our study sought to determine which early stage breast cancer therapy regimens had a subsequent reduced risk of mood disorders for a decade after the primary diagnosis. Methods This retrospective cohort study included newly diagnosed early stage breast cancer patients in Taiwan from 2000 to 2013 in Taiwan, according to the National Health Insurance Research Database. The mood disorder incidence in the BCS-WBRT group was lower than in the TM-no-WBRT group, according to the BCS-WBRT group's study. BCS-WBRT was associated with a reduced risk of mood disorder over a 10-year period compared to TM-no-WBRT in early stage breast cancer patients," according to the BCS-WBRT study.
Source link: https://doi.org/10.1007/s10549-022-06579-3
"Limitropeprogression is defined as a small metastatic clone that is resistant to on-going systemic therapy with a background of stable or responding systemic disease. " The aim of this research was to evaluate oligoprogressive prostate cancer patients treated with stereotactic body radiation therapy during systemic therapy to identify predictive factors and improve patient selection. During systemic therapy, we included PC patients treated with SBRT on a maximum of three sites of oligoprogression. FPP rates in 1- and 2-years were 81. 1% and 69. 9%, respectively. Median time to polymetastatic change was 33. 7 months. After SBRT was administered in 29 patients with a median NEST-FS of 15. 2 months, it was either switch or intensification of systemic therapy. Median DPFS was 8. 93 months, with median OS of 50. 6 months. In conclusion, we established the efficacy of SBRT for oligoprogression from PC, with the ability to prolong the on-going systemic therapy and interrupt the metastatic cascade. ".
Source link: https://doi.org/10.1007/s10585-022-10158-7
"Radiation therapy is a well-established, minimally invasive way of treating brain tumors. " The number of post-radiotherapy patients has increased in recent years, and delayed side effects have been evident. We screened 45 articles on RIAs from 1980 to 2021, and over 70% of RIAs were diagnosed after rupture. There was no significant difference in mRS between treatment and treatment methods, but conservative therapy was nonetheless strongly related to poor outcomes, which was not surprising. Surgeons should be aware of the de novo aneurysm formation in patients long after radiation therapy. ".
Source link: https://doi.org/10.1007/s10143-022-01820-5
"Purpose Hippocampus-avoidance whole brain radiotherapy with simultaneous integrated boost is a difficult treatment option for patients with multiple brain metastases, with the aim of preventing neurocognitive loss and simultaneously raising tumor control. " In this situation, achieving effective hippocampal dose reduction can be daunting. HA-WBRT+SIB's current research is intended to report and discuss the benefits of complete directional hippocampal blockage in lowering the hippocampal dose during HA-WBRT+SIB. HA-WBRT+SIB was reported on a number of patients with multiple metastases having undergone HA-WBRT+SIB. 30 Gy in 12 fractions to the entire brain, with 98% of the hippocampus receiving u2264 9 Gy and 2% resection cavities of 36 Gy in 12 fractions, and with SIB to metastases/resection cavities of 36 Gy and 12% in 12 fractions. During HA-WBRT+SIB, complete directional hippocampal blocking is a cost-effective strategy for obtaining improved hippocampal sparing. ".
Source link: https://doi.org/10.1007/s00066-022-01916-3
"Purpose Radiation therapy for triple-negative breast cancer therapy is currently available in the adjuvant setting and is being investigated as a neoadjuvant treatment booster. " However, TNBC radioresistance remains a barrier, so new biomarkers are needed to choose patients for any integration of RT in the TNBC therapy sequence. This systematic review sought to investigate the connections between miRs and TNBC's response to radiation as well as their potential predictive and prognostic values. After RT, miR-7, -27a, -205, 211, -221, and -221, as the most influential/reflecting TNBC response to IR, while miR-21, -139-5p, and -2021 are among those connected with TNBC patient outcomes after RT. "Dronemic review of circulating miRs may lead to increased monitoring and TNBC RT effectiveness, which is of particular concern in the neoadjuvant and high-risk patients'u2019 settings. ".
Source link: https://doi.org/10.1007/s10549-022-06533-3
"Introduction Intraoperative radiotherapy (Itroduction) "Introduction Intraoperative radiotherapy allows for the timely delivery of radiation therapy directly to the tumor bed. " A 1400 tumors treated with x-ray IORT show local, regional, and distant recurrence data, as well as overall and breast cancer-specific survival for 1400 tumors treated with x-ray IORT. Methods An analysis of Methods In a registry trial, a total of 1367 patients with 1400 distinct tumors were included. To be eligible for excision plus IORT as the only local treatment, histopathology had to announce tumor size u226430 mm, margins u22652 mm, no lymph nodes, and no significant lymphovascular invasion. Patients with restricted or whole breast radiation therapy were referred to additional surgery and/or complete breast radiation therapy. With 62 months of median follow-up, the 5-year Kaplanu2013Meier likelihood of any event involving all 1400 tumors was 5. 7 percent. It was 5. 98 percent for 1175 patients who underwent IORT alone. According to a multivariate study, biologic subtype luminal A and the addition of WBRT significantly reduced the possibility of local recurrence. ".
Source link: https://doi.org/10.1245/s10434-021-11295-1
"Background" It's unknown if the addition of anti-androgen therapy to late salvage radiation therapy may have oncological results comparable to those of early sRT in men with recurrent prostate cancer following surgery. Methods Data on 670 men who participated in the Radiation Therapy Oncology Group 9601 trial and who experienced biochemical recurrence were extracted using the National Clinical Trials Network data archive platform, with 670 men from the Radiation Therapy Oncology Group's 9601 trial and who experienced biochemical recurrence. Patients receiving delayed sRT versus early sRT were shown an elevated risk of overall mortality in patients receiving delayed sRT compared to early sRT; however, no change existed after the addition of concomitant AAT to late sRT. Similarly, the risks of cancer-specific mortality and metastatic progression of late sRT were higher for late sRT relative to early sRT, but not different after the addition of AAT to late sRT. Conclusions Poorer results associated with late sRT in men with chronic CaP may be rescued by the introduction of concomitant AAT. ".
Source link: https://doi.org/10.1245/s10434-022-11892-8
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