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Radiation Therapy - Europe PMC

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Last Updated: 12 June 2022

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Immunotherapy Combined with Radiation Therapy in Breast Cancer: A Rapidly Evolving Landscape.

"In breast cancer, programmed cell death 1 inhibitors in combination with chemotherapy have demonstrated significant clinical benefit in early-stage and metastatic settings; however, there are still many breast cancer patients who do not respond to these therapies. Given the effects of radiation therapy on the tumor micro-environment, RT and immune checkpoint blockade are both active areas of investigation. ".

Source link: https://europepmc.org/article/MED/35688527


Comprehensive review of hydrogel spacers prior to radiation therapy for prostate cancer.

"Introduction Radiation therapy is a curative intent therapy for prostate cancer patients with prostate cancer. " Hydrogel spacers have the ability to minimize rectal toxicity for prostate cancer patients undergoing radiation therapy. The body naturally reabsorbs the hydrogel content after radiation therapy. We wanted to present a comprehensive narrative and outline the benefits of inserting hydrogel spacers, as well as published research on the effect of hydrogel spacers on rectal dosimetry and toxicity. The effect on rectal dosimetry has been well established, and hydrogel spacers have been used to reduce rectal morbidity, which has been reported. Many future research questions remain, including the role of the hydrogel spacer in prostate stereotactic beam radiotherapy or post-radiotherapy local recurrence. Conclusions Hydrogel spacers are a low morbidity treatment that may help to minimize rectal risk in men with prostate cancer treated by radiation therapy. Future studies, which are currently ongoing, may contribute to further understanding of the role of hydrogel spacers in prostate cancer management. ".

Source link: https://europepmc.org/article/MED/35689413


Effect of the biologically effective dose of electron beam radiation therapy on recurrence rate after keloid excision: A meta-analysis.

"Background and purpose Adjuvant electron beam radiation therapy after keloid excision has been shown to be highly effective in reducing local recurrence. " Following a keloid excision based on accurate radiation dose data, we performed a meta-analysis of studies on hypofractionated electron beam radiation therapy to obtain a more precise estimate of the effects of the biologically safe dose on recurrence rate. Using forest plots and the best-fit lines on scatter plots, the recurrence rate with respect to the BED was determined. Results from the 28 studies that were selected for review included in the analysis, a total of 37 radiation dose datasets was extracted, with 3128 excised keloids identifying 3128. Both keloids had lower estimated recurrence rates at all locations as expected, as expected.

Source link: https://europepmc.org/article/MED/35688397


Safety and outcomes of combined immune checkpoint inhibitor and radiation therapy for patients with melanoma brain metastases

"The aim of this research is to determine the risks and effects of Immune Checkpoint Inhibitor and brain RT with a focus on timing of both treatments. " MetHODS This retrospective review included all consecutive patients treated for a brain metastatic melanoma with an ICI and brain RT from December 1, 2010 to April 30, 2018. Adverse Events version 5. 0, as a result of neurological adverse events graded with Common Terminology Criteria, the primary endpoint was neurologically impaired events graded by the Adverse Events Criteria. Adverse events in acute neurological Adverse Events – Grade 3 of the RT course lasted for 12. 3% of the course, with no difference between concurrent and non-u2013 concurrent groups. In comparison to 2. 7 months for WBRT, the median OS after RT was 11. 5 months for the whole cohort, with 15. 9 months for SRT. "According to 40% for non-u2013 concurrent groups, the objective response rate was much higher for concurrent ICI u2013 SRT group at 67 percent, relative to 40 percent for non-u2013 concurrent group. ".

Source link: https://europepmc.org/article/PPR/PPR503296


Surgical Management and Contralateral Breast Cancer Risk in Women with History of Radiation Therapy for Hodgkin Lymphoma: Results from a Population-Based Cohort.

"Background Women with a history of chest irradiation for Hodgkin lymphoma are at a greater risk of developing bilateral breast cancer," according to the researcher's contralateral breast cancer risk estimates in this population are undefined. Methods We investigated the SEER website for women treated with radiation therapy for Hodgkin lymphoma prior to age 30 years and were diagnosed with a new breast cancer diagnosis between 1990 and 2016. A subgroup analysis of mastectomy patients showed a 40. 5% bilateral mastectomy rate. The 5-year incidence of contralateral breast cancer in women who underwent unilateral surgery was 9. 4% [95% confidence interval], up to 29% at 10-year and 29. 9% at a 15-year follow-up, with 9. 4% rising to 22. 9 percent at 10-year and 29. 9% at 15-year follow-up. Women with a history of chest radiotherapy for Hodgkin lymphoma with a diagnosis of breast cancer have a 10-year contralateral breast cancer risk of 20%," the report says.

Source link: https://europepmc.org/article/MED/35668306


The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High Risk Prostate Cancer: A Validation Study from NRG/RTOG 0521.

"We conducted an a priori-designed validation study using serum samples from RTOG 0521. " The pre-treatment inflammatory state, according to the investigators, was hypothesized to predict clinical outcomes. Patients on the RTOG 0521 had serum banked for biomarker verification, according to the manufacturers' procedures. CRP levels were determined in pre-treatment samples. 202 patients in RTOG/NRG 0521 had serum samples available, according to the researchers. There was no correlation between high sensitivity and bDFS. Pre-treatment IL-10 was positively related to increased bDFs and distant metastases in the exploratory, unplanned analysis. The exploratory study of pretreatment levels of IFN-u03b3, IL-1b, IL-13, IL-23, and IL-23, all negatively associated with g 2 or higher ED was negatively related with g 2 or higher ED. Conclusions Pretreatment CRP is not linked to a poorer bDFS after RT, but it is not connected with a poorer bDFS. In a hypothesis-based review, higher baseline IL-10 levels were correlated with reduced bDFS rates. ".

Source link: https://europepmc.org/article/MED/35675855


Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer.

"Purpose Oligorecurrent prostate cancer restricted to the pelvic lymph nodes can be treated with whole pelvis radiotherapy. " In the para-aortic LNs, radiotherapy may also be helpful for oligorecurrent prostate cancer. Methods We compared a cohort of patients with oligorecurrent prostate cancer to the PA LNs, who were treated with elective, conventionally fractionated PA radiotherapy, plus simultaneous integrated therapy, which increased LN+ disease at our institution from 2015 to 2021. The transition from diagnosis to PA-RT was 5. 7 years. The median PSA at PA-RT was 3. 15 ng/mL. A LN+ disease patient received a SIB to a median dose of 62. 5 Gy. Nearly all patients received androgen deprivation treatment, with 52. 9% abiraterone. PA-RT's median follow-up time was 21. 5 months. There were two grade 3 chronic poisonous diseases and four chronic grade 2 toxicities, as well as four chronic grade 2 toxicities. PA-RT for oligorecurrent prostate cancer has low toxicity, with early disease prevention particularly encouraging. ".

Source link: https://europepmc.org/article/MED/35671868


Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.

"Several retrospective studies have demonstrated the effectiveness and safety of postoperative adjuvant external beam radiation therapy for patients with atypical and anaplastic meningiomas. Two phase II prospective studies by the Radiation Therapy Oncology Group and the European Organisation for Research and Treatment of Cancer have published the potential benefits of fractionated RT for patients with intermediate and high risk meningiomas; however, several issues remain a point of controversy.

Source link: https://europepmc.org/article/MED/35665867


Initial clinical experience of surface guided stereotactic radiation therapy with open-face mask immobilization for improving setup accuracy: a retrospective study.

"Purpose: "Purpose" is a term used to describe a particular surface-guided stereotherapy radiotherapy treatment technique with open-face mask immobilization and evaluation of the initial clinical success in improving setup quality. " Methods and materials The retrospective review of 48 SRT patients with head lesions was retrospectively reviewed. Patients' initial setup was demonstrated by 6DoF real-time deltas using the reference surface that was determined on the planning CT images. Results The absolute values of median CBCT couch shifts were 0. 4 mm in VRT, 0. 1 mm in LNG, 0. 2 mm in LAT, 0. 1 degree in YAW, 0. 1 degree in PITCH, and 0. 1 degree in ROLL. Conclusions: The latest findings from the proposed surface guided SRT procedure with open-face mask immobilization is a step forward in improving patient satisfaction and positioning accuracy in the same process.

Source link: https://europepmc.org/article/MED/35659685


Outcome of Patients with Soft Tissue Sarcomas of the Extremities and Trunk Treated by (Neo)adjuvant Intensity Modulated Radiation Therapy in Curative Intention

"BACKGROUND About Soft tissue sarcomas are a relatively uncommon group of malignant tumors. " In this single center retrospective review, patients receiving preoperative or postoperative intensity-modulated radiotherapy for STS of the extremities or trunk with curative intent were included. To determine the connection between survival endpoints and tumour-, patient-, and treatment-specific characteristics, we used multivariable proportional hazard models. RESULTS 86 patients were included in the study. Undifferentiated pleomorphic high-grade sarcoma and liposarcoma were the most common histological subtypes. Preoperative radiation therapy was used by more than a quarter of the patients. The median DMFS was 51 months, and the median DFS was 48 months. DFS dominated by male gender and histology of liposarcomas relative to UPS were more beneficial than UPS. CONCLUSION - CONCLUSION (Conclusion) Conformal, intensity-modulated radiotherapy is a safe treatment modality in STS preoperative or postoperative care.

Source link: https://europepmc.org/article/PPR/PPR502384

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions