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Radiation Therapy - DOAJ

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Last Updated: 12 June 2022

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Cost containment analysis and access to treatment associated with adopting hypofractionated radiation therapy from the brazilian perspective

"Summary: Background: According to estimates, breast cancer, the leading cause of cancer deaths in females worldwide, will continue to rise in incidence, highlighting the need for expanded treatment capacity. " Although postoperative radiation therapy is commonly used to reduce recurrence and mortality, studies has found that moderately hypofractionated radiation therapy and 5-fraction HFRT are both safe and cost-effective, and can reduce treatment costs. The potential annual savings were then estimated by comparing the cost of each program to the Brazilian cancer incidence rates in 2020. Patients with 15 fraction HFRT and 30% of patients with 5 fraction HFRT as compared to treating all patients with 25 fraction RT is $72,929,315. 40. In the Brazilian perspective, the cost analysis revealed decreased patients'u2019 costs and the potential for more EBRT services associated with HFRT.

Source link: https://doi.org/10.1016/j.lana.2022.100292


Initial clinical experience of surface guided stereotactic radiation therapy with open-face mask immobilization for improving setup accuracy: a retrospective study

"Abstract Purpose "Abstract Purpose: "Abstract Purpose" is a term that describes the initial clinical experience in improving setup quality. Methods and materials The retrospective analysis of 48 SRT patients with head lesions was retrospectively reviewed. Patient initial setup was illustrated by 6DoF real-time deltas using the reference surface obtained from the skin contour delineated on the planning CT images. CBCT training was used to derive the initial setup errors, and couch shifts for setup correction were implemented prior to treatment delivery. Conclusions The absolute values of median CBCT couch shifts were 0. 4 mm in VRT, 0. 1 mm in LNG, 0. 2 mm in LAT, 0. 1 degree in YAW, 0. 1 degree in PITCH, and 0. 1 degree in ROLL. Conclusions: The latest surface guided SRT surgery with open-face mask immobilization is a step forward in improving patient comfort and positioning accuracy in the same process. ".

Source link: https://doi.org/10.1186/s13014-022-02077-4


Stereotactic Body Radiation Therapy (SBRT) for Oligorecurrent/Oligoprogressive Mediastinal and Hilar Lymph Node Metastasis: A Systematic Review

"Steotactic body radiation therapy may play a significant role in therapeutic administration and in the so-called "no-fly zone" u201d, delivering high doses of radiation in remarkably few treatment fractions with excellent sparing of healthy surrounding tissues and low toxicity in relatively few therapeutic fractions. " The aim of this systematic review is to determine the safety and tolerability of SBRT in the treatment of mediastinal and hilar lesions, with special emphasis on the radiotherapy doses, dose limits for organs at risk, and clinical outcomes. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, two blinded investigators conducted a critical review of SBRT's treatment of oligoprogressive mediastinal and hilar metastasis. Results: A total of 552 articles were published, 12 of which were chosen with a total number of 478 patients treated with SBRT for mediastinal or hilar node recurrence. After thorax radiotherapy for stage III lung cancer, studies regarding SBRT for lung lesions or retreatment were also included. Different dose regimes were tested, with a higher prevalence of 4u20138 Gy in 5 or 6 fractions, but dose escalation was also used in 4 fractions with dose limits mainly derived from the RTOG 0813 trial. Half of the studies did not reveal toxicity greater than G3 nor G3 and only five cases of fatal toxicity were reported. ".

Source link: https://doi.org/10.3390/cancers14112680


Intraoperative Placement of an Absorbable Spacer Prior to Radiation Therapy for a Malignant Peripheral Nerve Sheath Tumor

"A 7-year-old female woman was found with a pelvic malignant peripheral nerve sheath tumor and lymph node metastases, and lymph node metastases. Following three cycles of postoperative chemotherapy, a 33-mm cystic lesion was discovered around the left iliac muscle, and proton beam therapy was recommended. AS avoided the surgical removal of spacers and instead gave us high-dose PBT for residual tumor without significant irradiation damage including infertility. ".

Source link: https://doi.org/10.1159/000524824


Whole Scalp Radiation Therapy for Recurrent Benign Cylindromas

"Cylindromas are a rare benign pathology that may manifest as multiple lesions on a patient's scalp," the doctor says. We present a case of a 74-year-old man with a known diagnosis of Brooke-Spiegler syndrome, a genetic disorder that results in multiple recurrent cylindromas. "With multiple grafts, he had approximately 70% surgery to remove recurrent lesions.

Source link: https://doi.org/10.1159/000524012


Comparative effectiveness of stereotactic body radiation therapy versus surgery for stage I lung cancer in otherwise healthy patients: An instrumental variable analysisCentral MessagePerspective

"Objectives: Stereotactic body radiation therapy (Sergency), "Objectives: Stereotactic body radiation therapy is a well-established primary treatment technique in patients with lung cancer with multiple comorbidities and/or advanced-stage disease. " However, its role in otherwise healthy patients with stage I lung cancer is uncertain. Methods: The National Cancer Database's Methods: From 2004 to 2016, we identified all patients with clinical stage I non-u2013small cell lung cancer. We identified otherwise healthy patients as those with a Charlson-Deyo comorbidity index of 0 and whose therapy program contained options for either SBRT or surgery. To determine relationships, we first used propensity score matching and Cox proportional hazard tables. We'll next try to determine the effects of SBRT versus surgery on long-term survival using an instrumental variables approach. Conclusions: Surgical resection is associated with a survival benefit in otherwise healthy patients with stage I NSCLC, as well as SBRT. ".

Source link: https://doi.org/10.1016/j.xjon.2021.09.052


Risk of Bacterial, Viral, and Fungal Infections in Patients With Solid Malignant Tumors Treated With Curative Intent Radiation Therapy

"We investigated the incidence and adjusted incidence ratio of infections in the year after the start of RT among patients receiving RT plus chemotherapy and RT monotherapy, by type of infection and severity of RT-induced lymphopenia. " Infections were more common among patients receiving RT plus chemotherapy than those who received RT monotherapy compared to patients who received RT monotherapy. The percentage of specific bacterial infections remained stable among patients who received RT Plus chemotherapy compared to those who received RT monotherapy was similar among patients who received RT plus chemotherapy. Patients who received RT plus chemotherapy with a lymphopenia grade of 1-2 or u22653, compared to no lymphopenia at the start of RT posed an elevated risk of bacterial infections 0 to 3 months after RT. The incidence rate of lymphopenia grade u22653 was reduced to specific bacterial infections in definite bacterial infections, while no lymphopenia was 2. 66 percent. ".

Source link: https://doi.org/10.1016/j.adro.2022.100950


Relative tumor volume has prognostic relevance in canine sinonasal tumors treated with radiation therapy: A retrospective study.

"Our hypothesis was that relative rather than absolute tumor volume influenced time to progress," says the fact that a larger tumor volume is related to a higher tumor stage. In 49 dogs with sinonasal tumors, we retrospectively investigated possible correlations of initial GTV to weight, body surface area, nasal cavity size, and tumor stage. According to imaging results in 34 dogs with an accessible follow-up computed tomography after definitive-intent radiation therapy with either a standard or a simultaneous boost protocol, the potential effects of absolute and relative GTV on response and outcome were evaluated. Stage 3 and 4 tumors were significantly larger than stage 1 and 2 tumors when considering GTV relative to nasal cavity. According to our findings, GTV relative to the nasal cavity may be prognostic for TTP, and a larger tumor volume relative to nasal cavity is correlated with a higher tumor incidence. ".

Source link: https://doi.org/10.1371/journal.pone.0269083


Successful Treatment with Radiation Therapy in an Older Patient with Endobronchial Schwannoma

"Bronchial schwannoma is extremely rare, accounting for a small percentage of benign bronchial tumors with no standardized treatment. An 89-year-old woman with a persistent cough underwent CT scan that revealed a tracheal tumor. Based on tissue obtained by high-frequency snare polypectomy, a diagnosis of endobronchial schwannoma was confirmed. In general, surgical resection is recommended for endobronchial schwannoma, but this patient's age made resection invasive.

Source link: https://doi.org/10.1159/000522408


Stage IB Endometrioid Type Endometrial Cancer: The Role of Lymphadenectomy and Adjuvant Radiation Therapy

All patients with stage IB endometrioid endometrial cancer who were admitted or treated in our hospital between January 1992 and Dec 2013 were retrospectively reviewed by the authors. Lymphadenectomy didn't work in 36 patients, and 23 patients did not have any sort of adjuvant therapy. Patients with grade1&2 tumor, 5-year disease free survival rates were 80% and 50%, respectively, and overall survival rates were 94. 8% and 93. 8%, respectively for patients who had or didn't have adjuvant radiotherapy. Although lymphadenectomy was not directly related to disease-free survival in this subgroup, this connection was still statistically significant for overall survival. Conclusion: Although the benefit of adjuvant radiotherapy in terms of prevention of recurrence in this subgroup was not directly related to disease prevention was not significant, more research needs to be confirmed. Patients with a myometrial invasion greater than half of myometrial thickness were able to recover after Lymphadenectomy.

Source link: https://doi.org/10.21613/GORM.2017.704

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions