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REPEAT - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 20 June 2022

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SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.

RNAs sequester RNA-binding proteins into nuclear foci and undergo repeat-associated non-AUG translation into toxic peptides in CGG repeat RNAs. Several SR proteins that act selectively with CGG repeats basally and under cellular stress We found several SR proteins that interact selectively with CGG repeats basally and under cellular stress. Lowering SRPK inhibitors reduced rodent neurotoxicity in both FXTAS and C9orf72 ALS/FTD model flies, and SRPK inhibitors reduced CGG repeat toxicity in rodent neurons. These results, together, reveal CGG repeat RNA binding proteins' involvement in RAN translation and repeat toxicity, as well as the further testing of SRPK inhibitors in modulating RAN translation in the context of repeat expansion disorders.

Source link: https://doi.org/10.15252/emmm.202114163

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions