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"OBJECTIVE" is a website that reviews the association between repeat resection and overall survival in patients with glioblastoma, but dismissing repeat resection's timing may have resulted in biased conclusions. Since the time of resection is included, the aim of this research was to show the change in the effect of repeated resection on OS in patients with glioblastoma. METHODS The authors conducted a retrospective review of patients who were first diagnosed with glioblastoma between January 2005 and December 2014 who were treated at Memorial Sloan Kettering Cancer Centers in January 2005 and December 2014. Repeat resection was attributed to a reduced risk of death when timing was factored in; however, repeat resection was correlated with a greater risk of death when timing was taken into account. CONCLUSIONS IN this research, the timing of repeat resection changed its protective effect on OS, suggesting that repeat resection will not benefit OS in all patients. ".
Source link: https://doi.org/10.3171/2017.6.jns17393
"The authors retrospectively reviewed the results from 59 patients who underwent repeat SRS for recurrent pain at a median of 30 months after the first SRS. Both the Barrow Neurological Institute Pain Scale and BNI Numbness Scale were assessed for pain results and prevention of trigeminal sensory dysfunction. Patients with this enhancement were reported to have lower actuarial rates of complete pain relief after the repeat SRS was lower than patients without the change five years ago. Patients with contrast enhancements had a higher risk of trigeminal sensory loss after repeat SRS than patients without contrast enhancement compared to patients without contrast enhancement at the 5-year follow-up. Dysthetic pain after repeat SRS was recorded for 8 patients with and 2 patients without contrast enhancement was present in 8 patients.
Source link: https://doi.org/10.3171/2016.5.jns16111
"OBJECTIVE" is a word that means "OBJECTIVE" refers to patients with brain metastases who experience local trauma after stereotactic radiosurgery. This review examines the clinical findings and dosimetric characteristics of patients who experienced tumor recurrence and were then treated with repeat SRS. METHODS Between 2002 and 2015, 32 patients were treated with repeat SRS for local recurrence of u22651 brain metastasis following initial SRS therapy. RESULTS Forty-six lesions in 32 patients were re-treated with a second course of SRS after local failure. Eleven of 46 lesions in 11 separate patients treated with repeat SRS were attributed to symptomatic radiation necrosis, according to symptomatic radiation necrosis. At 1 year, there was 71% freedom from radiation necrosis. The number of a lesion receiving 40 Gy was the most predictive predictor of radiation necrosis development, according to the analysis of dosimetric results. 3. 3 cm 3, 1. 60 cm 3, and 5 percent probability of radiation necrosis were correlated with 10%, 20%, and 50% likelihoods of radiation necrosis. CONCLUSIONS Repeat SRS appears to be an effective recovery option for patients with brain metastases as a result of local failure after initial SRS therapy. Although rates of radiation necrosis are high, repeat SRS may be recommended in those instances of local disease recurrence. Because the V40Gy is a predictor of radiation necrosis, treating this variable early in therapy planning could result in a decrease in radiation necrosis rates. ".
Source link: https://doi.org/10.3171/2016.5.jns153051
"OBJECT "British neoplasms like gliomas" are minimized during the removal of intrinsic cerebral neoplasms, such as gliomas, are identified by cortical and subtical white matter pathways essential for language, motor, and sensory function. The use of DES gives a rare opportunity to investigate brain plasticity in the context of neurological disease when a patient has more than 1 brain tumor resection as in the case of tumor recurrence. METHODS The authors investigated 561 cases in which patients underwent DES mapping after surgical forglioma resection, which included 561 patients. In this group of 561 patients, 18 were identified who underwent repeat surgery in which 1 or more stimulation centers were similar to those tested during the initial surgery. 94 of the 95 websites that were negative at the initial surgery were also negative at the repeat surgery, while one site was reported positive. Overall, 6 of 18 patients demonstrated loss of function at 1 or more motor or language centers between surgeries. At the time of repeat surgery, neurological impairment was not related to neurological impairment, so neurological function was preserved, despite neural circuit reorganization or activation of latent functional pathways. CONCLUSIONS The adult central nervous system reorganizes motor and language areas in patients with glioma. In the presence of continuously evolving structural lesions, adult neural plasticity may help to maintain motor and language function. The findings obtained from this subset of patients has sparked questions about brain plasticity in clinical settings.
Source link: https://doi.org/10.3171/2015.5.jns142833
"OBJECTIVE Patients with traumatic brain injury often have repeat head CT scans to determine the likelihood of injury. " This report is intended to determine the need for routine repeat head CT scans in patients with mild to moderate head injury, as well as an initial positive abnormal CT scan. METHODS This is a retrospective analysis of patients presenting to the emergency department from January 2016 to December 2017 with Glasgow Coma Scale scores > 8 and an initial abnormal CT scan, who underwent repeat CT during their in-hospital medical care. Patients who underwent surgery after the first CT scan had a GCS score 9, or had a normal initial CT scan were excluded. At least two CT scans on an inpatient basis were performed. Based on GCS score at admission, 51% had mild head injury and 45. 9% sustained moderate head injury. For 1033 patients, there were a total of 2636 CT scans, with a median of 2. 55 per patient. Because the rise of repeat CT without neurological impairment, there were no patients underwent surgery, no one was wrong, so the average number of repeat CT scans required to identify one such patient was 21. 3. CONCLUSIONS The role of routine repeat head CT in medically treated patients with head injury is disputed. The following findings: "In this research, the authors found lower GCS scores at admission, abnormal INR, the presence of midline shift, effaced basal cisterns, and multiple lesions on initial CT were all significantly correlated with the above results. ".
Source link: https://doi.org/10.3171/2019.8.focus19527
"METHODS Cases of non-u2013trauma-related neurosurgical patients treated at the Postgraduate Institute of Medical Education and Research before and during the COVID-19 pandemic were reviewed. Patients who required immediate intervention were surgically treated after a single COVID-19 test, while stable patients who were initially negative for COVID-19 were subjected to repeat testing at least 5 days after the first test and within 48 hours after the planned surgery. The COVID-19 positivity percentage was compared to the local period prevalence. Following a negative first test, the number of patients who became infected during the surgical procedure without second testing was used to determine the probable number of people who may have been infected with the surgical procedure without second testing. Results of this article An estimated of 1769 non-trauma-related neurosurgical patients included in this study, a mean of 37. 2 patients underwent surgery per month before COVID-19, with a median of 184. 2 patients underwent surgery per month during the pandemic period, when COVID-19 cases were on the rise in India during the period of COVID-19. While the number of patients undergoing surgery for chronic benign diseases decreased, there was a significant rise in the number of patients undergoing surgery for a ruptured aneurysm, stroke, hydrocephalus, and cerebellar tumors. 4 patients tested for the disease at the first COVID-19 exam were found to have the disease, a proportion that was 3. 7 times higher than that in the local community. ".
Source link: https://doi.org/10.3171/2020.9.focus20705
"OBJECTIVE OBJECTIVE This study, which was conducted by 11 C-methionine PET/CT coregistered with volumetric MRI, may lead to remission in patients with persistent acromegaly due to a postoperative lateral disease residual" in patients with persistent acromegaly, contributing to the presence of persistent acromegaly due to a postoperative lateral disease residual. METHODS The authors found 9 patients with persistent acromegaly following primary surgery in whom further surgery was initially considered out of reach due to equilibrescent MRI findings of suspected lateral sellar and/or parath disease. RESULTS Met-PET/MR CR found focal tracer uptake in all nine patients, which was linked to sites of suspected residual tumor in volumetric MRI. CONCLUSIONS This research shows that Met-PET/MR CR can be helpful in the diagnosis of persistent lateral sellar/paraphrasedoutput in a subgroup of patients with persistent acromegaly and assist with targeted revision TSS.
Source link: https://doi.org/10.3171/2020.3.focus2052
"OBJECTIVE Recurrent lumbar disc herniation is a significant contributor of morbidity in patients undergoing lumbar discectomy, and has been found in up to 18% of cases. " Also in the absence of instability, repeated discectomy is often fruitful in treating these patients, but concern over repeat RLDH may lead surgeons to advocate instrumented fusion even though there is no uncertainty. The authors' aim was to compare clinical outcomes for patients undergoing repeat discectomy versus instrumented fusion for RLDH. Methods From 2012 to 2015 The authors used the National Neurosurgery Quality and Outcomes Database to determine the results of patients who underwent repeat discectomy versus instrumented fusion at a single institution from 2012 to 2015. Conclusions The authors' 3- and 12-month follow-up data found 25 repeat discectomy and 12 instrumented fusion patients. Patients undergoing repeat discectomy had dramatically shorter hospital times and length of stay, and they paid significantly less hospital fees. ".
Source link: https://doi.org/10.3171/2016.5.spine1616
"We investigated whether alternative recognition motifs for ligand binding from synthetic libraries of Designed Ankyrin Repeat proteins could be integrated into CARs," the researcher found. Our in vitro findings reveal that DARPin CARs manufactured with flexible linkers and with short and long spacer domains exhibit specific cytotoxicity, cytokine secretion, and proliferation against EGFR+ targets that are comparable to the Cetuximab CAR's. CARs were tested in an in vivo breast cancer tumor model with EGFR+ MDA-MB-231 tumor cells and revealed improved anti-tumor clearance with both E01 DARPin and Cetuximab scFV CARs. An EpCAM-specific DARPin chimeric costimultatory receptor can also be used in conjunction with a scFV CAR targeted ROR1 to produce combinatorial antigen recognition and improve T cell function against tumor cells that are both targets. "Enhanced T cell secretion and proliferation" in EpCAM-specific DARPin CCR combined with first or second generation ROR1 scFv CARs improved T cell secretion and proliferation.
Source link: https://doi.org/10.1158/2326-6074.tumimm16-a75
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