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People with pyruvate dehydrogenase deficiency have gastrointestinal difficulties as well. Certain affected individuals have abnormal brain regions, including underdevelopment of the tissue connecting the left and right halves of the brain, wasting away from the cerebral cortex's outer layer, or patches of damaged tissue on certain parts of the brain. However, some individuals with pyruvate deficiency do not live past childhood, although some do live into adulthood or adulthood.
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