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Farnesoid X receptors are bile acid receptors that play a key role in lipid, glucose, and energy homeostasis. FXR-null mice were fed either a normal or a high-fat diet to investigate FXR's effects on NAFLD and the potential mechanism. We reported an increase in PDK4 expression in FXR knockout cells after subsequently. In addition, inhibition of PDK4 expression in vivo and in vitro helped lipid accumulation in hepatocytes caused by FXR deficiency in vivo and in vitro.
Source link: https://europepmc.org/article/MED/35251469
Primary lactic acidemia leading to high morbidity and mortality is a common cause of primary lactic acidemia leading to high morbidity and mortality, but there are few treatment options. PDC's E1 component is a symmetric dimer of heterodimers encoded by PDHA1 and PDHB. Invariant Arg349 accounting for 22% of arginine replacements in the Arg112-Arg224 stretch and of E1-Argent Arg residues, comprising 40% and 39% of cases, respectively, with invariant Arg349 accounting for 22% of arginine replacements. According to SASA's study, 86% and 84% of residues with non-duplicate DMVs of E1 and E1, respectively, are solvent inaccessible. Arg349 represented 74% of the buried E1 Arg residues involved in SSIC, accounting for 74% of the buried E1 Arg residues. Structural perturbations resulting from residue replacements in several matched neighboring pairs of amino acids on different subunits of SSIC are similar in terms of interatomic distance.
Source link: https://europepmc.org/article/MED/35038180
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