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"Because these receptors are extremely widespread in both central and peripheral nervous systems, blocking fluoxetine's action on nicotinic receptors can play a key role in its antidepressant and other therapeutic effects. ".
Source link: https://doi.org/10.1073/pnas.94.5.2041
"In accordance with the electrophysiological findings, fluoxetine reduced the binding of [3 H]5HT to 5HT 2C receptors expressed in HeLa cells, and the binding of 5HT receptors in rat cortex membranes was also reduced but not as effectively. " Our findings show that fluoxetine is a potent and reversible antagonist of 5HT2C receptors, and that some therapeutic effects of fluoxetine may require blockage of 5HT receptors, in comparison to the traditional blockage of 5HT transporters.
Source link: https://doi.org/10.1073/pnas.94.5.2036
"Fluoxetine is the most commonly prescribed drug for depression treatment. " At the protein kinase A site, Thr-34, and the casein kinase-1 site, Ser-137, the phosphorylation of DARPP-32 rises, and decreases phosphorylation at the cyclin-dependent kinase 5 site, Thr-75, increases phosphorylation of DARPP-32. At Ser-831 and Ser-845, Fluoxetine also raises phosphorylation of the u03b1-hydroxy-5-isoxazolepropionic acid receptor subunit GluR1'. Both the fluoxetine-mediated rise in AMPA receptor phosphorylation at Ser-845u2013GluR1 and the beneficial response to fluoxetine in an animal study of antidepressant activity in a mouse test of antidepressant activity were significantly reduced in DARPP-32 knockout mice, suggesting a vital role for this phosphorylation in fluoxetine's antidepressant behavior. Increased phospho-137-32 mRNA and protein, as well as reduced ability to raise phospho-137. 32 and phospho-Ser-831, respectively. U2013GluR1: Mice chronically treated with fluoxetine had elevated amounts of DARPP-32 mRNA and protein, as well as a decreased ability to raise phospho-137-137, phospho-Ser-831. u2013GluR1. These regular shifts may be relevant to the earliest onset of fluoxetine's therapeutic success.
Source link: https://doi.org/10.1073/pnas.052712799
In most cells, a key regulator of cellular potassium A class of potassium channels, called K2P channels, modulates resting membrane potential. " In two configurations and tied to a Prozac metabolite, the human K2P channel, TREK-2, was determined to have the same geometry of the human K2P channel, TREK-2. The structures demonstrate how ligand binding or mechanical stretch could cause switching between the states. K2P channels are not intended for Prozac, but they can be affected by side effects," Prozac's bans say.
Source link: https://doi.org/10.1126/science.1261512
"The total drug concentration in cord blood was 80 ng/mL. " The fluoxetine level, 26 ng/mL, is below the adult therapeutic average, but the norfluoxetine cord blood test, 54 ng/mL, is at the adult therapeutic level. The fluoxetine level was not measurable at 96 hours, and the norfluoxetine level was 55 ng/mL. fluoxetine's half-life is 2 to three days, and norfluoxetine's is 7 to 9 days. Interestingly, in our patient, the fluoxetine was absent in the blood at 4 days, but norfluoxetine was present. Adult patients' most common side effects of Prozac include central nervous system, including anxiety, tremor, jitteriness, and occasionally seizures. In this infant, central nervous system symptoms were the most common. In adults who are taking Prozac, Cardiovascular side effects are less apparent.
Source link: https://doi.org/10.1542/peds.92.5.721
"Abstract The MYC family of transcription factors is a key source of human cancer and potential therapeutic interest," says the author. For the anti-neuroblastoma activity of the drug, we show that using DNA editing techniques, we show that Prozac's stabilisation of p27 Kip1 operated in MYC-activated cells is vital for the drug's anti-neuroblastoma activity. In addition, dosing mice with a dose of Prozac equivalent to that used in long-term clinical trials in children with psychiatric disorders displayed a significant decrease in metastatic disease in two models of high-risk neuroblastoma. Prozac's favourable toxicity profile means that long-term therapies could be introduced in children with MYC/CKS1 high neuroblastomas. ".
Source link: https://doi.org/10.1038/s41389-019-0186-3
"I argue that the ramifications of Prozac's brain model are so revealing that commentators are compelled to consider not only the appearance of normality but also the nature of nature itself. " These debates should not be understood as reactions against reductionism - to a biology that shuts down - but rather as a movement that opens up the connections between nature, culture, biology, and the individual, rather than as objections to reductionism - which leads to changes that are now cross-cut and spurred by artificiality. I suggest that Prozac critiques should be understood not as reactions against reductionism, rather than as objections to reductionism - to - In conclusion, I argue that the biology presented by psychopharmacology's supporters is not limited to the frequent conclusions that are made about materialist science's claims, but also some of the terms and concepts that are commonly used in the social sciences.
Source link: https://doi.org/10.1177/095269510101400303
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