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Protocol - Europe PMC

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Last Updated: 24 July 2022

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Scaling up Locally Adapted Clinical Practice Guidelines for Improving Childbirth Care in Tanzania: A Protocol for Programme Theory and Qualitative Methods of the PartoMa Scale-up Study.

Our pilot study in Zanzibar enhanced patient care by locally co-created intrapartum clinical practice guidelines and accompanying training. We discuss social practice theory and advocate for its place within program theory and toward qualitative evaluations of shifts in clinical practice. Birth attendants' motivations and family culture, as well as other common childbirth care activities, will be examined in line with our program's goals and competencies. Insights based on principles of co-creation and contextualization, the research results will not only clarify active ingredients that make the PartoMa intervention usable, but also establish the knowledge base for scaling-up and replicabability of future interventions based on the principles of co-creation and contextualization.

Source link: https://europepmc.org/article/MED/35311627


Different frequencies of repetitive transcranial magnetic stimulation combined with local injection of botulinum toxin type A for post-stroke lower limb spasticity: study protocol for a prospective, single-center, non-randomized, controlled clinical trial.

No definitive consensus has been reached on the safety and effectiveness of low- or high-frequency repetitive transcranial magnetic stimulation in the treatment of post-stroke muscle spasticity. Botulinum toxin type A alone can cause more muscle spasticity after combined with local botulinum toxin type A injections. Patients with post-stroke muscle spasticity admitted to the Department of Rehabilitation Medicine at the First Affiliated Hospital of China Medical University will be included in this trial. Patients with significant cerebral edema will be given local injections of botulinum toxin type A and low-frequency repetitive transcranial magnetic stimulation on the affected side; Group B: Patients with widespread cerebral enfarction will receive local injections of botulinum toxin type A and low-frequency repetitive transcranial magnetic stimulation on the affected side; Group B: Patients with extensive cerebral inflammatory infarction will be given local injections of botulinum toxin type A; Patients with cerebral axial magnetic stimulation on the artery blockachal infarction will receives of cerebral grafton type A; Group A; Group B; Group B; Group A; Group B; and transcranial magnetic stimulation on the congenus cerebral artery grafton of artery perf xin type A; and infarction; and low-frequency neuro stimulation on the axial artery grafton artery xinfarction; Patients with cerebral grafte vascular graftus cerebral infarction; Patients with massive cerebral infarction; In the treatment of patients with post-stroke lower limb spasticity treated with tight grouping and standardized procedures, we hope to reach a definitive conclusion on whether there are differences in the safety and effectiveness of low- or high-frequency repetitive magnetic stimulation as well as botulinum toxin type A injections, thereby determining the correct therapeutic regimen.

Source link: https://europepmc.org/article/MED/35535901


Effects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury: study protocol for a randomized controlled trial.

Classic paired with social stimulation can promote synaptic plasticity, as shown by animal experiments and human clinical trials in spinal cord injury patients. However, it is also unknown if paired associative magnetic stimulation will promote lower limb motor function improvement after spinal cord injury. We predict that central and peripheral magnetic stimulation will converge at the synapse, promoting synapse function and improving the relevant muscle's motor function. This research examined the effects of paired associative magnetic stimulation on neural circuit development by evaluating changes in motor evoked and somatosensory functions of the lower limbs, occupational health, and daily life in patients with spinal cord injury. In a 1:1 ratio, 110 thoracic spinal trauma patients treated in the Department of Spinal Cord Injury, China Rehabilitation Hospital, will be randomly assigned to research and control groups in a 1:1 ratio. Change in lower limb American Spinal Injury Association Impairment Scale motor function scores from baseline to last follow-up is the primary outcome measure of this trial. Changes in lower limb American Spinal Injury Association sensory function score, motor evoked capabilities, sensory evoked potentials, modified Ashworth scale score, Maslach Burnout Inventory score, and Hamilton Depression Scale scores have all been reported over time. Motor provoked potential latency stems from corticospinal tract transmission time, while amplitude reflects recruitment capability; both steps will help to clarify the mechanism behind synaptic growth's effect of paired associative magnetic stimulation.

Source link: https://europepmc.org/article/MED/35535897


Study protocol for development of an options assessment toolkit (OAT) for National Malaria Programs in Asia Pacific to determine best combinations of vivax radical cure for their given contexts

Introduction: Recent advancements in G6PD deficiency screening and treatment are quickly changing the landscape of radical cure of vivax malaria available to National Malaria Programs. While NMPs are awaiting the WHO's global policy guidance on these developments, they will also need to consider additional contextual factors such as the vivax burden, health system infrastructure, and financing available to support changes to their policies and practices. This protocol outlines the OAT development process. Methods The OAT will be developed in four phases, with the NMPs and experts playing active roles in designing the research process and the toolkit. Using participatory research techniques, the OAT will be developed in four phases where the NMPs and experts will play active roles in the design of the study process and the toolkit will be included. In the final phase, the OAT will be pilot-tested with other Asia Pacific NMPs. The Northern Territory, Department of Health, and Menzies School of Health Research all approved a human research ethics committee.

Source link: https://europepmc.org/article/PPR/PPR523063

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions