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Protocol - DOAJ

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Last Updated: 24 July 2022

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Effects of cardiovascular health, musculoskeletal health and physical fitness on occupational performance of firefighters: protocol for a systematic review and meta-analysis

Methods and estimates The purpose of this systematic review and meta-analysis is to determine the effect of cardiovascular wellness, musculoskeletal health, and physical fitness on firefighters' occupational results. The Rayyan Intelligent Systematic Review system will be used to screen and select studies for inclusion, and results from the included studies will be included on the researcher-generated data extraction form. The methodological evaluation of each study will be carried out by the appraisal tool for cross-sectional studies checklist and the Critical Appraisal Skills Programme toolkit. This research was granted ethical permission by the University of the Western Cape Biomedical Research Ethics Committee, requiring the integration of quantitative findings from multiple studies to achieve coherence. Ethics and dissemination This research's summary would require the integration of quantitative findings from multiple studies in order to achieve coherence.

Source link: https://doi.org/10.1136/bmjopen-2022-061435


Treatment of intracranial neoplasia in dogs using higher doses: A randomized controlled trial comparing a boosted to a conventional radiation protocol

Background information Inadequate radiation dose delivery can cause intracranial tumor formation. Brain dose elevations must be controlled in order not to risk debilitating adverse effects such as radiation necrosis. Hypothesis The new protocol, a 10-u00d7 4 Gy + 11% physical dose increase, limited to the macroscopic tumor volume increase, has resulted in a clinically higher outcome compared to a 10 u00d7 4 Gy regimen. Animals Fifty’s Seven Customers With primary intracranial neoplasia, five clients from Fifty-u2010own dogs with primary intracranial neoplasia. With an increase of 4. 45 Gy's dose increase, twenty-u2010eight dogs were assigned to the control protocol and 29 to the simultaneous integrated boost protocol. In 5 dogs, Mild, transient acute or earlyu2010delayed adverse radiation effects had been found. Conclusion and Clinical Importance The dose escalation used with an 11% physical dose rise did not result in improved outcomes, but not in improved outcomes.

Source link: https://doi.org/10.1111/jvim.16472


From registration, protocol to report: are COVID-19-related RCTs in mainland China consistent? A systematic review of clinical trial registry and literature

Design The objective of this study was to provide a comprehensive review of licensed COVID-19-related randomized controlled trials in mainland China and determine the credibility of reporting by comparing registrations, protocols, and full reports. The ISRCTN registry and EU Clinical Trial Registry were accessed on January 1, 2022. Trial trials were excluded from observational studies, non-randomised studies, and single-arm trials. Data extraction and synthesis were performed by two reviewers independently from registrations, papers, and risk of bias analysis for trial reports. Both protocol and RCT full report was published in seven trials. In mainland China, between protocols and full studies, 5 studies revealed significant differences in primary outcome or time frame measurement. Conclusions Between protocols and full papers, 5 studies' discrepancy in reporting COVID-19-related RCTs revealed confusion in reporting COVID-19-related RCTs.

Source link: https://doi.org/10.1136/bmjopen-2021-058070

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions