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Last Updated: 24 September 2022

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Muenke syndrome: long-term outcome of a syndrome-specific treatment protocol

OBJECTIVE The authors reviewed the long-term effects of their Muenke syndrome rehabilitation program, which involves a single craniofacial biopsy. METHODS This was a prospective observational cohort study of Muenke syndrome patients who underwent craniosynostosis surgery within the first year of life. RESULTS The study included 38 patients; 36 patients underwent fronto-supraorbital reconstruction. In six patients, three patients had Chiari I malformation, and tonsillar descent 5 mm was observed. Ten patients developed ventriculomegaly, and the OFC growth curve was deflected in three patients. Hearing loss was felt by twenty-two patients. Patients with Muenke syndrome treated with a single fronto-supraorbital increase in their first year of life only exhibit signs of intracranial hypertension, despite the fact that the condition is so low. The patient follow-up should concentrate on visual analysis and speech and hearing findings.

Source link: https://doi.org/10.3171/2019.5.peds1969


Utility of a cervical spine clearance protocol after trauma in children between 0 and 3 years of age

Object Cervical spine decompression in children aged 0u20133 years of age is deceptively difficult. The purpose of this investigation was to determine whether a safe and effective protocol-driven procedure could be developed for clearance of the cervical spine in noncommunicative children aged between 0 and 3 years of age. Children under the age of 0 to 3, including intubated patients who were admitted after trauma activation at Primary Children's Medical Center in Salt Lake City or the Children's Hospital of New York from 2002 to 2006 were treated according to a cervical spine clearance protocol. During the investigation period, a total of 2828 pediatric trauma activations required cervical spine clearance. Conclusions The test has been safe in detecting cervical spine injury in noncommunicative children following trauma. Even in very young patients, the cervical spine without CT or MR imaging studies is a possibility in the majority of cases.

Source link: https://doi.org/10.3171/2009.10.peds09159


Using knowledge translation as a framework for the design of a research protocol.

Knowledge translation has been characterized as the synthesis, dissemination, exchange, and ethically-sound application of knowledge to improve health, resulting in a more efficient health care system. It will begin with a description of integrative knowledge translation, followed by the presentation of a concrete case study in which integrative knowledge translation was used to create a nursing intervention.

Source link: https://doi.org/10.32920/ryerson.14668878


Using knowledge translation as a framework for the design of a research protocol.

Knowledge translation has been characterized as the synthesis, dissemination, exchange, and ethically-sound use of knowledge to improve health, resulting in a more efficient health-care system. It will begin with a description of integrative knowledge translation, followed by the presentation of a concrete case study in which integrative knowledge translation was used to design a nursing intervention.

Source link: https://doi.org/10.32920/ryerson.14668878.v1


Examining the influence of treatment preferences on attrition, adherence and outcomes: a protocol for a two-stage partially randomized trial

Background: Empirical evidence pertaining to the influence of treatment choices on attrition, adherence, and outcomes in intervention evaluation studies is inconsistent. Participants' preferences for the treatments under scrutiny are intended to test these variables by implementing the two-stage partially random or preference trial scheme and administering a validated questionnaire to determine participants'u2019 preferences for the medications under scrutiny. Participants in two trial arms are randomized to two test arms. The random arm for random assignment to treatments is the first and most important arm of treatment allocation, which involves allocation to the selected therapy. Participants with persistent insomnia are being targeted. Two behavioral therapies, stimulus control therapy, and sleep restriction therapy are combined in the same style and dose, and both behavioral therapies are available. Examine: The benefits and drawbacks of the preferred trial design are discussed. The difficulties in starting the trial were discussed in relation to the enrollment of participants in the populations identified by treatment received and method of treatment allocation.

Source link: https://doi.org/10.32920/ryerson.14639127.v1


Examining the influence of treatment preferences on attrition, adherence and outcomes: a protocol for a two-stage partially randomized trial

Background: Empirical evidence regarding the effect of treatment choices on attrition, adherence, and outcomes in intervention evaluation studies is mixed. Participants' preferences for the medications under review are intended to determine these conditions by implementing the two-stage partially randomized or preference trial scheme and administering a controlled survey to determine participants'u2019 preferences for the treatments under scrutiny. The random arm oversees random assignment of medications, and the second is the preference arm, which involves allocation to the desired therapy. Participants with persistent insomnia are primarily targeted. Both behavioral therapy and sleep restriction therapy are available in the same shape and dose. To gather evidence on attrition, a participant log is used to collect data. Describe: The advantages and disadvantages of the preference trial design are discussed in this article. The challenges in starting the trial are related to the recruitment of participants in the populations characterized by disease received and method of treatment allocation.

Source link: https://doi.org/10.32920/ryerson.14639127


Effect of Wearable Resistance Loading during Warm-Up Protocol on Front Kick Biomechanics in Taekwondo

This study aims to investigate and determine the effects of wearable resistance loading during warm-up protocols on front kick movement mechanics and muscle stimulation. As participants of the investigation, twenty-five male university taekwondo athletes were recruited as participants. Overall, the findings showed that there were no significant differences between different WR loadings in kinematics, kinetics, and muscle activation during front kick mobility. Wearable resistance did not improve kicking results, as shown by kicking speed. The wearable resistance can be used during warm-up in training sessions as an add-on to resistance training, depending on the percentage of loadings used that are seen as not reducing the results. Future studies should investigate wearable resistance as a useful tool in improving taekwondo kicks' results.

Source link: https://doi.org/10.17309/tmfv.2022.2.11


Efficacy of mindfulness-based intervention (‘mindfulness-based joyful sleep’) in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a prospective protocol of a randomised controlled trial in China

According to reports, mindfulness-based interventions are more readily available within the community than cognitive behavioral therapy for insomnia, which was also recommended as the preferred non-pharmacological treatment by the American Academy of Sleep Medicine, are more effective in insomnia management and can reduce inflammation markers in older people with insomnia. This study aims to compare the effectiveness of an MBI to CBT-I in young and middle-aged insomnia sufferers with insomnia disorder, as well as the effects of nuclear factor kappa B, a transcription factor that controls the expression of genes involved in inflammation. The primary outcome is sleep quality as determined by the Pittsburgh Sleep Quality Index, the severity of insomnia symptoms diagnosed by the Insomnia Severity Index, and sleep measurements obtained using sleep diary and polysomnography. If Mindfulness-Based Joyful Sleep is proven to be safe, it will help bridge the void between the unmet need and the demand for insomnia treatments in China.

Source link: https://doi.org/10.1136/bmjopen-2018-027061

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions