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Prostate Cancer - Springer Nature

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Last Updated: 24 April 2022

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MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer

Background and context of Androgen receptor signaling following castration therapy is a common clinical finding in prostate cancer. Earlier, we explored the role of MYB overexpression in androgen-depletion resistance and PCA aggressiveness. Results in the PCa cells MYB and AR co-localize and co-localize. Even when cultured under androgen-deprived conditions, MYB-overexpressing PCa cells maintains AR in the nucleus. When implanted orthotopically and quickly regain growth following castration that resulted in shorter mice survival, MYB-overexpressing PCa cells show increased tumorigenicity, which is comparable to those with low-MYB-expressing prostate tumours.

Source link: https://doi.org/10.1038/s41416-021-01641-1


Recurrent vesicourethral anastomotic stenosis following treatment for prostate cancer: an effective endoscopic treatment using bipolar plasma button and triamcinolone

Purpose: The objective of this review is to determine the safety of deep bladder neck incision plus adjuvant Triamcinolone in the treatment of recurrent vesicourethral anastomotic stenosis after prostate cancer surgical treatment. Materials and methods A retrospective review of patients undergoing bladder neck surgery from 2013 to 2019 was conducted. Patients who had previously undergone surgical treatment for prostate cancer and had failed therapy for bladder neck contracture were included.

Source link: https://doi.org/10.1007/s11255-022-03153-0


Staging ^68 Ga-PSMA PET/CT in 963 consecutive patients with newly diagnosed prostate cancer: incidence and characterization of skeletal involvement

Purpose The aim of the study was to define the prevalence and pattern of skeletal involvement in a large population of patients with newly diagnosed prostate cancer using Ga-68 PET/CT staging in a single center. The prevalence of bone involvement, the type of bone metastases, and the severity of disease were found and correlated with the ISUP Grade Group's requirements and PSA ratings. Bone metastases were found in 188 of 963 patients. In 10. 7% of patients with PSA 10 ng/dL, 6. 6 percent of patients with GG 2/3, and 8. 9% of patients with GG 4/5 were found. Osteoblastic type metastases were the most common form of bone metastases observed in 133 of the patients with malignant bone involvement. Skeletal pathogens may also be present in patients with GG 2/3 and PSA.

Source link: https://doi.org/10.1007/s00259-021-05655-y


Intensity-modulated radiation therapy for prostate cancer after rectal surgery: a single hospital long-term safety analysis

Background radiotherapy is a treatment option for prostate cancer patients following rectal surgery; however, the toxicity profile of radiotherapy for those patients has yet to be clarified. This review sought to determine the long-term toxicities and efficacy of intensity-modulated radiotherapy in patients with prostate cancer who had undergone rectal surgery. Methods We retrospectively reviewed patients with prostate cancer after rectal surgery, who were definitively treated with IMRT between January 2000 and December 2019 at our hospital. According to researchers, the incidences of grade 2 acute genitourinary and gastrointestinal toxicities were 14. 3% and 0% respectively. When the rectal anastomosis dose was limited to 70 Gy, no acute or late toxicities were discovered. Conclusions This retrospective review showed that IMRT for patients with prostate cancer following rectal surgery may be safe and efficient with rectal dose limitation of D _max 70 Gy if more than five years have passed since surgery.

Source link: https://doi.org/10.1007/s10147-022-02124-w


Prostate cancer treatment and the relationship of androgen deprivation therapy to cognitive function

Prostate cancer is the second most common type of cancer in men. Between 25 and 50% of ADT men on ADT have some degree of cognitive dysfunction that may be self-reported or reported by a family friend, according to the authors. The loss of testosterone aide may have hindered cognitive function with ADT, according to some. Although a concrete causal association between ADT and cognitive decline in prostate cancer patients has yet to be established, this report explores the controversies surrounding the possible relationship between ADT and neurocognitive deterioration.

Source link: https://doi.org/10.1007/s12094-021-02727-1


Barriers and facilitators to accessing and utilising post-treatment psychosocial support by Black men treated for prostate cancer—a systematic review and qualitative synthesis

Purpose To summarize findings from published studies on barriers and facilitators to Black men accessing and using post-treatment psychosocial services after prostate cancer treatment. Black men aged 18 to 18, 18 and reporting experiences of, or suggestions for, psychosocial care after CaP treatment were included. Four analytical constructs were discovered: psychosocial support for dealing with treatment side effects; facilitators to use of psychosocial assistance; and pragmatic strategies for planning and delivering post-treatment psychosocial assistance. Conclusions Few intervention studies have focused on Black CaP survivors' behavior, with current research mostly focusing on Caucasian males. A collaborative approach to CaP care requires not only medical expertise but also the confidence of Black men as representatives of their illness experience, as well as the presence of cultural and social media networks.

Source link: https://doi.org/10.1007/s00520-021-06716-6


Bone marrow mesenchymal stem cells promote the progression of prostate cancer through the SDF-1/CXCR4 axis in vivo and vitro

Purpose of this Research The purpose of this research was to investigate the SDF-1/CXCR4 axis' involvement in the development of BMMSC homing in prostate cancer in vivo and in vitro. BMMSCs had an elevated CXCR4 expression as a result of increasing SDF-1 levels, and elevated SDF-1 had a major promoting effect on cell proliferation and migration in BMMSCs. In addition, the CXCR4 expression of BMMSCs in the non-contact co-culture model with vascular endothelial cells was significant elevated, and analysis of this model revealed that BMMSC proliferation and migration of BMMSCs were promoted in the presence of VECs. Four GFP-transplanted mice were found to have prostate tumorigenesis in two groups, a PCa group, and a control group. CXCR4 was also increased in the prostate tissue of PCa mice, which is evidently elevated.

Source link: https://doi.org/10.1007/s12094-021-02740-4


Patient participation in treatment decision-making of prostate cancer: a qualitative study

Purpose: Despite increasing implementation of decision-making tools for prostate cancer patients, no one is aware of patients' personal involvement and perception throughout the decision-making process. This research was designed to investigate patients' experiences and attitudes toward treatment decision-making. Methods We undertook a qualitative interview with 30 patients with prostate cancer. Patients, sociocultural reasons, and patient autonomy during treatment; and III. Advance care planning and advance care planning, fewer future worries, are emerging, future focus and advance care planning are poorly understood, and acceptance of advance care planning are more widespread. Conclusions from the study report show that patients with prostate cancer have a variety of needs to improve their ability to make treatment decisions, and healthcare professionals should educate patients, as well as providing decision aids or decision support for patients.

Source link: https://doi.org/10.1007/s00520-021-06753-1


The relationship between sleep hygiene, mood, and insomnia symptoms in men with prostate cancer

Purpose: Insomnia symptoms are common among men after prostate cancer treatment. In PCa patients, we investigated how sleep hygiene habits and psychological disorders are linked to insomnia symptoms. Participants with insomnia sufferers had significantly elevated rates of anxiety, depression, exhaustion, and sleepiness, as well as poorer sleep hygiene than those with insomnia symptoms. Control variables accounted for 11. 9% of the insomnia severity variance. Moreover, including sleep hygiene items "I think, plan, or be concerned when I am in bed" and "I sleep in uncomfortable bedroom" explained an additional 3. 6 percent of the variance in insomnia symptoms. Conclusions: Poor sleep quality, exhaustion, sleeplessness, fear, and depressive symptoms were all related to elevated insomnia symptoms in PCa patients. Improving sleep hygiene and treating psychological disorders may help avoid and/or alleviate insomnia symptoms in PCa patients.

Source link: https://doi.org/10.1007/s00520-021-06680-1


Risks of metabolic diseases and androgen deprivation therapy for prostate cancer in a Chinese population: a prospective multi-centre cohort study

A growing trend has emerged for Androgen deprivation therapy use in prostate cancer. In Chinese patients, we are investigating the connection between ADT and the development of metabolic disease. This is a prospective multi-centre cohort from the READT website, in which patients diagnosed with PCa and ADT were prospectively recruited since 2016. For this research, Chinese patients recruited from Hong Kong were selected and compared to another cohort of newly diagnosed PCa patients in Hong Kong, who were collected prospectively and extracted retrospectively. ADT 151 patients were treated and 447 were not receiving ADT, respectively, were listed as ADT recipients. In ADT patients, initiation of new drugs is also more common. Conclusions Chinese children receiving ADT are exposed to elevated risks of new-onset hypertension, diabetes, and hyperlipidaemia, as well as a greater risk of pharmaceutical surveillance for pre-existing comorbidities.

Source link: https://doi.org/10.1007/s11255-022-03151-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions