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Prostate Cancer - Springer Nature

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Last Updated: 24 November 2022

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Comparative Analysis of Breast and Prostate Cancer Prediction Using Machine Learning Techniques

Basically, cancer can develop in any organ of the body, and although each form of cancer has specific characteristics, most cancerous processes that cause cancer are extremely common in both disease types. Breast cancer is one of the most common forms of cancer in females. In the direction of their early forecasts, this research focuses on breast cancer as well as prostate cancer. Breast and prostate cancer risk predictions are among the three separate datasets used in this study. Both breast cancer and one for prostate cancer data are downloaded from the UCI and Kaggle repository, respectively. With or without using feature selection, both the tests with or without using feature selection yielded good results with 80% accuracy. With feature selection doing the best work on Wisconsin Breast Cancer with 99% accuracy, logistic regression with feature selection doing the best work on Wisconsin Breast Cancer with 99% accuracy. There are four classifiers that have the highest accuracy on prostate cancer detection.

Source link: https://doi.org/10.1007/978-981-19-2821-5_54


Health-related quality of life in long-term Caribbean prostate cancer survivors: comparisons with prostate cancer-free men

Purpose Prostate cancer and its treatment can have a positive effect on health-related quality of life. In long-term PCa users of African ancestry from low- and middle-income countries, there are no studies on HRQoL. We investigated the effect of demographic and clinical variables on these findings, as well as the effect of socioeconomic and clinical variables on these results. Methods PCa patients treated with and without ADT, as well as PCa-free controls from a case–u2013control study of ten years post enrolment. The symptoms burden scores of PCa survivors and controls were similar, excepting exhaustion and dyspnoea, which were the highest in males on ADT and controls. The most common contributors to HRQoL in PCa survivors were underlying medical conditions and marital status. Conclusion PCa's illness was not an determinant of long-term HRQoL in Jamaican men.

Source link: https://doi.org/10.1007/s11136-022-03202-2


Two calix[4]pyrroles as potential therapeutics for castration-resistant prostate cancer

Meso-calix[4]pyrrole and meso-calix[4]pyrrole have previously been reported to have cytotoxic activity against lung cancer cells. Here, we present pre-clinical and in vitro studies demonstrating that these calixpyrrole derivatives can reduce cell proliferation in both PC3 and DU145 prostatic cancer cell lines. These results show that these calixpyrroles might be novel therapeutic agents for prostate cancer treatment, and that are of particular concern for the treatment of androgen-independence-resistant prostate cancer.

Source link: https://doi.org/10.1007/s10637-022-01294-8


^99mTc-PSMA SPECT in Prostate Cancer

PSMA-PET/CT imaging is becoming a standard of care in prostate cancer imaging, and has been included in recent NCCN guidelines, but widespread access is still a problem, since the 68Gallium branded PSMA tracer is required to purchase 68Gallium generator and labelling devices, which is an issue. This pictorial essay focuses on our initial experience using 999 millionTc-PSMA SPECT, which supports further investigation as it delivers promising results for prostate cancer imaging and may also play a role in pre-radioligand therapy evaluation in the future.

Source link: https://doi.org/10.1007/s40336-022-00498-5


ImmunoPET for prostate cancer in the PSMA era: do we need other targets?

Introduction Prosecutors have been gaining prominence in prostate cancer management in recent years, with prostate specific membrane antigens proving an effective way to integrate diagnosis and therapy in a new way, namely theranostics. However, in up to 20% of PC cases, low or absent PSMA expression has been recorded. Prostate stem cell antigen, a biomarker that was overexpressed in metastatic castration-resistant PC, was successfully captured in animal models by immunoPET with 124I and 89Zr-conjugated antibody fragments, yielding promising results as a preliminary radioimmunotherapeutic target in preliminary radioimmunotherapeutic applications.

Source link: https://doi.org/10.1007/s40336-022-00520-w


The maximum standardized uptake value in patients with recurrent or persistent prostate cancer after radical prostatectomy and PSMA-PET-guided salvage radiotherapy—a multicenter retrospective analysis

Purpose Objectives This study is designed to investigate the connection between the highest standardized uptake value in positron-emission tomography targeting prostate-specific membrane antigen prior to rescue radiotherapy in a large multicenter population. Methods Patients who underwent 68 Ga-PSMA11-PET before surgery were enrolled in four high-volume centers in this retrospective multicenter study. Only patients with PET-positive local recurrence and/or nodal recurrence within the pelvis were included. SUVmax values were notably related to poor BRFS, and there was a trend for SUVmax values u2265 median. The SUVmax value in NR was not significantly related to BRFS, not significantly related to BRFS. Prote aims and Conclusions The non-invasive biomarker SUVmax can help patients with sRT and recurrence confined to PSMA-PET's prostatic fossa.

Source link: https://doi.org/10.1007/s00259-022-05931-5


Cost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial

Background and Aim The current and Objectives The purpose of this paper is that most existing prostate cancer screenings in the United Kingdom, Europe, and North America do not recommend targeted population-wide screening for prostate cancer. Prostate-specific antigen-based screening can reduce prostate cancer-specific mortality, but there are questions about overdiagnosis, overtreatment, and economic value, according to prostate cancer-specific mortality. The model was calibrated to results from the Cluster Randomised Trial of PSA Testing for Prostate Cancer, which was released in 2007. The Prostate Testing for Cancer and Treatment trial's results were modelled for treatment effects. We recommend the use of pre-biopsy multi-parametric magnetic resonance imaging for men with prostate-specific antigen u2265 3 ng/mL and combined transrectal ultrasound-guided and targeted biopsies. From a National Health Service perspective, the key success metrics were projected lifetime costs and quality-adjusted life-years. Although the polygenic risk-stratified screening methods were not on the cost-effectiveness frontier, there was evidence to show that they were less cost-effective than alternative age-based approaches, as demonstrated.

Source link: https://doi.org/10.1007/s40273-022-01191-1


Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer

Apalutamide is a next-generation androgen receptor antagonist for prostate cancer treatment. Autophagy upregulation is one of the mechanisms by which prostate cancer cells survive APA anti-tumor therapy in vitro, and we have previously reported it. The mice treated with APA+ Chl demonstrated reduced expression of ATG5, Beclin 1 and LC3 punctuations, as well as an increase in P62 as seen by immunofluorescence and WES. The decrease in Ki-67 protein was correlated with an increase in caspase 3 and endothelial CD31 protein expression. Conclusion These results show that a APA + Chl supplementation leads to reduced autophagy levels and tumor suppression in comparison to APA monotherapy. Hence, the increased antitumor activity of APA in conjunction with autophagy inhibitors could be a new therapeutic option that could be more accessible to patients.

Source link: https://doi.org/10.1007/s00432-022-04059-1


Stem Cells as Target for Prostate cancer Therapy: Opportunities and Challenges

Tumor formation, expansion, and relapse in Prostate Cancer and other cancers have been found by cancer stem cells and cells in a cancer stem cell-like state; therefore, new approaches to target these cellular populations have been developed. Hence, here we would highlight the importance of determining the TLR3 and P53 levels in PCa patients before beginning an immunotherapy based on PIC +9cRA to determine whether they will respond to treatment. In addition, the use of drugs that raise p53 expression in PCa patients, whether you're looking for medications that raise p53 levels, is encouraged to potentiate the use of PIC+RA-based immunotherapy in these patients.

Source link: https://doi.org/10.1007/s12015-022-10437-6


MRI determined prostate volume and the incidence of prostate cancer on MRI-fusion biopsy: a systemic review of reported data for the last 20 years

Purpose: Magnetic resonance imaging is a repeatable, systemic, and cost-effective imaging technique when compared to transrectal ultrasound, which is highly operator-dependent. In the literature, the negative correlation between prostate volume and the incidence of prostate cancer in TRUS biopsy has been well documented. The purpose of this systemic review is to evaluate the published MRI-fusion study findings on prostate biopsies, determining any association between prostate volume and PCa prevalence. This is the first systematic review of published MRI-Fusion results on the prevalence of PCa in relation to prostate volume, according to our knowledge. This MRI review confirms previous TRUS-biopsy findings that showed an inverse correlation between prostate volume and the prevalence of PCa, which also supports the argument that large prostates can be protective against PCa when compared to smaller prostates.

Source link: https://doi.org/10.1007/s11255-022-03351-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions