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Prostate Cancer - DOAJ

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Last Updated: 24 November 2022

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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

Many cancers, including prostate cancer, have been found to be present in several cancers, including prostate cancer. The integrated stress response pathway, which has been described as a stress reduction pathway, has been shown to be effective in several cancers, including prostate cancer. Both in vitro and in vivo, we show that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa, as well as in vivo, and is present in PCA patient samples. GCN2 was shown to regulate expression of over 60 solute-carrier genes, including those involved in amino acid transport and loss of GCN2 function, as shown by RNA-seq transcriptome analysis and a CRISPR-based phenotypic screen.

Source link: https://doi.org/10.7554/eLife.81083


Risk of prostate cancer in patients with inflammatory bowel disease: a nationwide cohort study in South Korea

Background: Several studies have shown a correlation between inflammatory bowel disease and prostate cancer risk. Objectives: Using the Korean National Health Insurance Service database, we compared prostate cancer risk according to IBD status. Methods: The risk of prostate cancer in patients with IBD and controls was compared between patients with IBD and controls using the Cox proportional hazards regression model and Kaplan-Meier survival analysis. Results: During a median follow-up of six years, the prevalence of prostate cancer in non-IBD patients was 264 per 100,000 person-years and 242 per 100,000 person-years in patients with IBD. non-IBD patients versus IBD patients did not differ by IBD status non-IBD patients versus IBD patients, but the cumulative incidence of prostate cancer was not different among IBD patients versus IBD patients: log-rank p = 0. 27; non-IBD patients versus Crohn's disease versus Crohn's disease: log-rank p = 0. 42.

Source link: https://doi.org/10.1177/17562848221137430


MRI-measured adipose features as predictive factors for detection of prostate cancer in males undergoing systematic prostate biopsy: A retrospective study based on a Chinese population

paraphrasedoutput:Methods: We retrospectively reviewed the results of 901 men undergoing ultrasonography-guided systematic prostate biopsy between March 2013 and May 2022. Results: Patients with PCa and clinically significant PCa were found to have higher PPAT thickness and subcutaneous fat thickness than those without PCa, based on variables that were not selected by multivariate logistic regression and prediction nomograms. Patients with csPCa had a higher PPAT thickness than those with non-csPCa.

Source link: https://doi.org/10.1080/21623945.2022.2148885


HLA-BAT1 alters migration, invasion and pro-inflammatory cytokines in prostate cancer

Prostate cancer accounts for more than 1 in 5 diagnoses and is the second cause of cancer-related deaths in males. Although PCa can be safely administered, patients can suffer cancer recurrence, and there is a need for new biomarkers to increase the likelihood of prostate cancer recurrence and treatment. HLA-associated transcript 1 was differentially expressed in patients with elevated Gleason scores when compared to poor Gleason scores, according to our laboratory results. In tumors derived from BAT1 shRNA cells that were not isolated from BAT1 cDNA cells, we found up-regulation of TNF-u03b1, IL-6, and MMP10 in tumors derived from transfected BAT1 shRNA cells, as compared to tumors derived from BAT1 cDNA cells in tumors derived from BAT1 shRNA cells in our in vivo studies.

Source link: https://doi.org/10.3389/fonc.2022.969396


Time to Castration Resistance as a Predictor of Response to Docetaxel in Metastatic Castration Resistance in Prostate Cancer

paraphrasedoutput:Methods: This analysis looked at real-life experiences of first-line docetaxel therapy for metastatic castration-resistant prostate cancer, as well as whether the reaction time to ADT could predict docetaxel therapy. Patients with TTCR greater than 12 months were randomized to group 1, while patients with TTCR > 12 months were randomized to group 2. Results: Patients with a median survival of the patients in group 1 was 16 months, compared to group 2. In group 2's median PFS was 7 months, the median PFS was 14 months, with the patients in group 2 suffering progression-free survival of the patients. Group 2 had a statistically higher PFS than group 1 on average.

Source link: https://doi.org/10.4274/imj.galenos.2022.56804


Prostate cancer metastasis mimicking appendicitis—A rare but important differential diagnosis in PET/CT imaging

Prostate cancer is the most common cause of lymph nodes, bones, the liver, and the lung. In recent literature, Prostate cancer carcinomatosis with a propensis of the appendix is not well understood, and is often associated with acute appendicitis as the primary presentation. With an increase in PSA value, a 65-year-old male with a history of recurrent prostate cancer was given an increase in PSA. Nodular tissue growth and increased PSMA uptake in the prostate, appendix, and several intra- and extra pelvic lymph nodes, according to 18F-PSMA-1007 PET/CT.

Source link: https://doi.org/10.1016/j.radcr.2022.10.024


Plug inguinal hernia repair mimicking nodal spread of prostate cancer on PSMA-PET/CT

PSMA tracer uptake along the left external iliac vessels corresponding to a building resembling a lymph node on computed tomography was found in this situation. On PSMA PET, this case illustrates PSMA uptake due to surgical mesh from inguinal hernia plug repair as a nodal metastatic disease mimic.

Source link: https://doi.org/10.1016/j.radcr.2022.09.107


Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy

paraphrasedoutput:Methods, a documentary examination performed in the SEER database, found 31,002 PCa patients treated with RT with at least one DHRC, including a 020 ng/dL, biopsy Gleason Grade Group 4) and their effect on cancer-specific mortality in prostate cancer patients treated with external beam radiotherapy. In all R/E subgroups, except in 1984, the results of 31,002 patients, 20,894 were Caucasian, 5256 were Mexican-Latino, and 1984 were Asian, with 5256 being Asian. According to R/E, individual DHRCs and combinations of two DHRCs differed, but not for the combination of three DHRCs. In addition, the effect of DHRCs on absolute and relative CSM measurements differed within the four evaluated R/E groups.

Source link: https://doi.org/10.1080/2090598X.2022.2148867


Race‐specific prostate cancer outcomes in a cohort of military health care beneficiaries undergoing surgery: 1990–2017

Abstract Background The majority of prostate cancer mortality rates in Caucasian American, African American, Asian, and Hispanic men are among Caucasian American, African American, Asian, and Hispanic men, however, these estimates are unable to distinguish race or ethnicity from confounding causes. The current research investigates how survival differences in long-term PCa results among self-u2010 reported AA and CA men as well as examining clinicopathologic findings in self-u2010reported CA, AA, Asian, and Hispanic men. Compared to CA men, AA men had a markedly reduced time from RP to BCR, but no difference was made between AA and CA men for a period from BCR to metastasis, and overall death ranging from metastasis to total death; however, there was no difference between AA and CA men. Conclusions : AA men had a shorter survival time from RP to BCR, but in a similar manner, BCR to metastasis and metastasis to overall death in an equal access health care setting.

Source link: https://doi.org/10.1002/cam4.4787


Establishment of an age‐ and tumor microenvironment‐related gene signature for survival prediction in prostate cancer

Abstract Background The prevalence of prostate cancer is on the rise as a result of age, as well as tumor microenvironment, which are both important in PCa formation, but no underlying mechanisms have been fully understood. Based on the newly identified age and TMEu2010related differentially expressed genes, the association of ATRS with immuneu2010related characteristics of PCa patients was also determined, as well as the ATRS-u2010 prediction nomogram. TCGA 2005PRAD patients' immune cells' compositions changed with age. Prognostic DEGs from nine age-u2010 and TMEgs were identified, and the ATRS of each TCGA-u2010PRAD patient was calculated based on the identified nine DEGs. Conclusions Age and TME played significant roles in PCa, and the ATRS gene signature was shown to be closely related to PCa's immuneu2010related characteristics, as well as good results in predicting PCa patients's OS.

Source link: https://doi.org/10.1002/cam4.4776

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions