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Prostate Cancer - Astrophysics Data System

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Last Updated: 24 April 2022

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Mathematical modeling of prostate cancer progression in response to androgen ablation therapy

Prostate cancer progression is largely due to the complex interactions between testosterone, its active metabolite DHT, and androgen receptors. It is hypothesized that starting antiandrogen therapy in an intermittent, as opposed to continuous, fashion could lead to improved disease control with fewer treatment-related toxicities. Model simulations are able to capture a variety of clinically observable outcomes for "average" patient outcomes under various intermittent schedules. In the absence of a competitive advantage of androgen-dependent cancer cells over castration-resistant cancer cells, intermittent scheduling can result in more frequent treatment failures than continuous therapy, according to the model. Given the near-universality of antiandrogen treatment failure in the absence of competing mortality, such simulation has the possibility of expanding into clinical trials and then into a diagnostic tool for individual patients.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..10819701J/abstract


From the Cover: Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

The metastatic migration of cancer cells from primary tumors to distant ecological niches, rather than primary tumors, is the cause of much cancer mortality [Zhang QB, et al. ] Chambers AF, Goss PE Breast Cancer Res 10:114; Int J Cancer 126:2534-2541; Chambers AF, Goss PE Breast Cancer Res 10:114; Int J Cancer 126:2534-2541; Chambers AF, Int J Cancer 126:2534-2541; Chambers AF, Int J Cancer 126. 2534-2541; Chambers AF, Int J Cancer 126:2534-2541; Int J Cancer 126: Int J Cancer AF, Int J Cancer Res 10: 104; Int J Cancer 126: The Tepui's invasive ascents were recorded using highly metastatic PC-3 and noninvasive LNCaP prostate cancer cells as a test case. prostate cancer cells from the lowlands to the tops of the Tepui were photographed using confocal microscopy and used as a measure of relative invasion. The less-metastatic cells never populated all available tops, leaving about 15% of them unoccupied, but the more populated Tepuis occupied all available Tepuis.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..108.6853L/abstract


Nano-Theranostics for the Sensing, Imaging and Therapy of Prostate Cancers

Prostate cancer is one of the most common ailments in men and a common cause of male cancer death. The aim of this review is to summarize some of the most recent advancements in prostate cancer sensing and treating. Regarding recent developments in simultaneous PET-MRI as well as optical imaging in vitro and in vivo, this article also discusses pertinent case studies that hold promise for the next generation of dual modality medical imaging of PCa. In addition, we include an overview of biosensing techniques aimed at PCa: prostate biomarkers such as Prostate Specific Antigen have been integrated into synthetic platforms and studied in the context of sensing and imaging applications in preclinical studies on the early detection of PCa. These were some of the latest lively debates that currently impede nanotechnology's clinical progresses. Lastly, some of the societal questions surrounding PCa detection are considered and discussed along with the concerns about nanoparticle toxicity are discussed and addressed together with the toxicity of nanoparticles. The continuing development of new probes and methods for simultaneous imaging and therapy monitoring used for PCa diagnosis and therapy would be of concern to both the biomedical research community and those interested in the advancement of the application of theranostics specifically in PCa diagnosis and treatment, as well as those interested in the design of new probes and methodologies for PCa targeting.

Source link: https://ui.adsabs.harvard.edu/abs/2022FrCh...10.0133C/abstract


Dynamic changes in gene alterations during chemotherapy in metastatic castrate resistant prostate cancer

Patients with metastatic castrate resistant prostate cancer patients are a common treatment option. Docetaxel chemotherapy is a common treatment option for metastatic castrate resistant prostate cancer patients. To date, the genetic variations that accounted for the emergence of resistance in mCRPC patients during chemotherapy therapy have not been fully defined. However, the clonal underlying mechanisms of these key driver cancer genes during chemotherapy in mCRPC patients have yet to be determined. We also did a retrospective review of cell-free DNA alterations in blood samples collected from mCRPC patients before and after chemotherapy to see if effect and clinical outcomes were monitored.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.4672T/abstract


An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

In vitro, benzoxazinoids in rye have demonstrated their ability against PC, but human studies are lacking. For 6 wk, patients with indolent PCs consumed 485 g whole grain rye bran or fiber supplemented refined wheat daily, using a quantitative method for analysis of 22 BXs, including novel metabolites found by mass spectrometry and NMR, was developed and applied to plasma samples from a random crossover research. After rye vs. refined wheat intake, most BXs were noticeably higher in plasma. After rye vs refined wheat intake, BX metabolites were much higher.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.5260N/abstract


Muscle wasting assessment tools for prostate cancer

Muscle wasting may be induced by Prostate cancer and its treatment. Due to the limited availability of high-quality equipment for routine diagnosis, body composition and muscle function are rarely assessed in patients with prostate cancer in developing countries. This cross-sectional analysis examined the relationship between several simple methods for determining muscle mass and function with a more sophisticated measure of muscle wasting among Mexican men with prostate cancer. These findings support the early detection and management of muscle wasting alterations in older adults with prostate cancer.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.4662E/abstract


Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence

The genetic link to prostate cancer onset and clinical heterogeneity has a significant effect on disease stratification accuracy. When compared to the BPH group, the PC group had a significant higher risk of the T risk variant and TT genotype. The TT genotype had a significantly higher incidence among younger PC patients based on their age at diagnosis and that it was linked to a higher risk of BCR.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.4546P/abstract


Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis

Despite advancement in prostate cancer therapy, distant metastasis remains a significant cause of morbidity and mortality from PC. According to this, it is increasingly apparent that preventing or delaying PC metastasis has a huge potential for dramatically improving patient outcomes. Here we present receptor-interacting protein kinase 2 as a clinically actionable target for preventing PC metastasis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13..669Y/abstract


Mathematical model of hormone sensitive prostate cancer treatment using leuprolide: A small step towards personalization

We first focus on the model's fine detail, then we present numerical evaluation of the system, starting from the simplified model with no resistance and ending on the full model with two resistance mechanisms present. We conclude that the model is able to represent reality, that is, in clinical situations, the level of testosterone in HSPC patients eventually rises, contributing to ADT's failure.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1763648F/abstract


A protocol for the VISION study: An indiVidual patient data meta-analysis of randomised trials comparing MRI-targeted biopsy to standard transrectal ultraSound guided bIopsy in the detection of prOstate cancer

Background Transrectal ultrasound guided biopsy for prostate cancer is prone to random and systemic error, and has been shown to have a negative predictive value of 70%. PRECISION and PRECISE were among the first randomised studies to investigate the new MRI-targeted biopsy route for a non-paired approach to detect clinically significant prostate cancer and avoid unnecessary therapy. An individual patient data meta-analysis was planned from the start of the two studies in parallel, and this IPD meta-analysis aims to clarify the use of MRI-TB as the most common diagnostic pathway for prostate cancer. Only randomised controlled trials comparing the MRI-targeted biopsy pathway and the traditional TRUS biopsy route will be included. In each arm, the most notable result of the study is the percentage of men with clinically significant prostate cancer in each arm.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1763345K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions