Advanced searches left 3/3

Primary Ovarian Insufficiency - Springer Nature

Summarized by Plex Scholar
Last Updated: 07 June 2022

* If you want to update the article please login/register

A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions

"Primary ovarian insufficiency causes female infertility by excluding normal ovarian functions. " c. 92delT/c. 92delT mice developed meiotic DNA repair defects as a result of RAD51 and HSF2BP/BMRE1 accumulation in the chromosome axes, leading to a decrease in the number of crossovers. In vitro and in explanted mouse bone marrow cells, repair of mitomycin-C-induced chromosomal aberrations was impeded. According to reports, the Rad51b-c. 92delT variant reduced replication fork propagation of patient-derived lymphoblastoid cell lines and pluripotent reprogramming success of primary mouse embryonic fibroblasts. ".

Source link: https://doi.org/10.1038/s41418-022-01021-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions