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Primary Ovarian Insufficiency - Europe PMC

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Last Updated: 07 June 2022

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A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.

"Primary ovarian insufficiency leads to female infertility by abolishing normal ovarian function. " Due to RAD51 and HSF2BP/BMRE1 accumulation in the chromosome axes, a decrease in the number of crossovers was observed in the number of crossovers. In vitro and explanted mouse bone marrow cells, repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c. 92delT human and mouse somatic cells. According to the Rad51b-c. 92delT variant, the replication fork development of patient-derived lymphoblastoid cell lines and pluripotent reprogramming effectiveness of primary mouse embryonic fibroblasts was reduced. And, finally, Rad51b c. 92delT/c. 92delT mice with an elevated risk of pituitary gland hyperplasia. ".

Source link: https://europepmc.org/article/MED/35624308


Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts.

"Objective "objective" "Objective "To study signs of premature menopause and more specifically the presence of autoimmune primary ovarian insufficiency in European women. In a cross-sectional review of 6870 women, the age at menopause and self-reported cause for menopause were categorized according to gender at menopause and self-reported cause for menopause. Results Premature menopause was found in 2. 8 percent of women, and these women had higher incidences of nulliparity, obesity, osteoporosis, hormone replacement therapy, and never smokes compared to women with menopause u226540 years ago. In 91 and non-ovarian causes in 27 women, 26 women, were identified as POI of unknown origins, resulting in a 1. 1% incidence of idiopathic POI. 4. 5% of POI cases were of presumably autoimmune origins, based on the presence of autoantibodies against 21 OH and SCC. Idiopathic POI affects 1. 1% of all women and almost half of the women with premature menopause.

Source link: https://europepmc.org/article/MED/35521804


Profile genome-wide DNA methylation of human granulosa cells in primary ovarian insufficiency

"We investigate whole DNA methylation of POI by whole genome bisulfite sequencing, determine the pattern of DNA methylation in POI, and identify the POI-related POI gene locators. " Follicular fluid samples were obtained from three women with POI and three women with normal ovarian reserve, according to scientific and experimental methods. From each follicular fluid sample, Ovarian granulosa cells were purified. WGBS' whole genome DNA methylation sequencing of the granulosa cells was performed. The average percentages of methylated cytosines in CG settings exceeded 99% in CHG and CHH settings, although CHG and CHH contexts were less than 1%. In CHG and CHH, the average methylation level in CG was about 80%, but in CHG and CHH it was less than 0. 4 percent. "There was no significant difference in CpG methylation level between NOR and POI," according to NOR.

Source link: https://europepmc.org/article/PPR/PPR497290

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions