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"Understandably, several meiotic-related genetic factors were found to be mutationated in POI patients and mouse models, showing the correlation between meiosis and ovarian reserve. " In this article, we provide an overview of the genetic causes of meiotic prophase I and their pathogenic mechanisms in POI. ".
Source link: https://doi.org/10.4103/2096-2924.224209
"Objective: To investigate the prevalence of autoimmune primary ovarian insufficiency in European women. In a cross-sectional review of 6870 women, postmenopause and self-reported cause for menopause were categorized according to age at menopause and self-reported cause for menopause. Conclusions: Premature menopause was present in 2. 8% of women, and these women had higher incidences of nulliparity, obesity, osteoporosis, hormone replacement therapy, and never smokers compared to women with menopause u226540 years ago. In 91 and non-ovarian causes in 27 women, it was discovered, and 27 women were classified as POI of unknown origins, resulting in a 1. 1% prevalence of idiopathic POI. 4. 5% of POI cases had a likely autoimmune origin, based on the presence of autoantibodies against 21 OH and SCC. Idiopathic POI affects 1. 1% of all women and almost half of the women with premature menopause, according to the author.
Source link: https://doi.org/https://doi.org/10.1530/EC-22-0024
"Objective: To discuss a rare case of primary ovarian insufficiency and review the institutional barriers in place that restrict reproductive autonomy for Black women who require third-party reproduction. " Conclusion: The field of assisted reproductive technologies has grown at an exponential rate, but not all are benefited. "We must not forget to investigate the causes that contributed to racial and socioeconomic inequalities in reproductive care access, use, and outcomes as we continue to expand knowledge and develop assisted reproductive technologies. ".
Source link: https://doi.org/10.1016/j.xfre.2021.09.004
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