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Preterm Birth - Springer Nature

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Last Updated: 21 July 2022

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Preterm birth and postpartum depression within 6 months after childbirth in a Brazilian cohort

This report sought to determine the relationship between PTB and PPD by comparing populations of pregnant and full-term mothers in two Brazilian cities with differing socioeconomic characteristics. This prospective convenience cohort study examined 1421 women during pregnancy, birth, and the postpartum period. PPD was administered to assess PPD within six months after delivery, and women were thought to have been emotionally affected if scores were EDPS u2265 12. According to the directed acyclic graph method, a multivariate Poisson regression was used to determine relative risk of PPD in mothers of premature infants, and the final analysis models were adjusted for psychosocial variables, which were adapted to the directed acyclic graph approach. PTB and PPD were not confirmed in two large samples from two Brazilian cities with differing socioeconomic status. Prenatal care can help minimize unwanted outcomes for mothers, infants, and families in the quest for lowering unfavorable outcomes for mothers, infants, and families.

Source link: https://doi.org/10.1007/s00737-022-01248-2


Prophylactic administration of human amniotic fluid stem cells suppresses inflammation-induced preterm birth via macrophage polarization

Ascending inflammation of the vaginal region is a common cause of preterm birth. Human amniotic stem cells are mesenchymal stem cells with potent anti-inflammatory properties in animal models of perinatal diseases such as periventricular leukomalacia, myelomeningocele, and neonatal sepsis. However, hAFSC therapy for inflammation-induced preterm birth has yet to be evaluated. We used a preterm mouse model of aging disease in order to determine the therapeutic effects of hAFSC transplantation in order to determine the therapeutic effects of the disease in pregnant mice. In addition, we monitored the fluorescence of fluorescently labeled hAFSCs using an in-vivo imaging device, and hAFSC aggregation was determined using immunohistochemistry analysis. In the mouse model, inflammation-induced preterm birth was reduced by hAFSC injection to the peritoneal cavity. This is the first research to show that hAFSCs are safe in the treatment and prevention of inflammation-induced preterm birth.

Source link: https://doi.org/10.1007/s11010-022-04512-2


Effect of maternal thallium exposure in early pregnancy on the risk of preterm birth

However, the analysis of the correlation between maternal Tl exposure during pregnancy and the risk of preterm birth is patchy so far. We wanted to look into the connection between Tl exposure in early pregnancy and the risk of PTB. The analysis included a total of 2104 pregnant women from the Tongji Maternal and Child Health Cohort in Wuhan, China. Our findings revealed that maternal Tl exposure during early pregnancy was positively linked to PTB risk, to the risk of PTB, and that Tl exposure during early pregnancy can have a sex-specific effect on PTB.

Source link: https://doi.org/10.1007/s11356-022-19332-6


Understanding and Reducing Persistent Racial Disparities in Preterm Birth: a Model of Stress-Induced Developmental Plasticity

Preterm birth is a leading cause of neonatal mortality in the United States and is characterized by substantial racial inequalities. Maternal stress is a risk factor for preterm birth, but it is more often treated as a secondary variable rather than a primary target for intervention. Here, we present a simulation of stress-induced developmental plasticity, in which maternal worry is a key environmental cue influencing the length of gestation and therefore a primary target for intervention. Black women face disproportionate and unique maternal pressures due to perceived misogyny and misogyny. Black women also have higher rates of preterm birth than Black women, which is therefore not surprising. The downstream effects of racism on preterm birth pathophysiology may indicate an appropriate response to stressors within the highly conserved maternalu2013placental neuroendocrine stress axis. According to the above, simple, stress-reducing strategies that support pregnant women can reduce rates of preterm birth and birth outcomes for all women, particularly Black women.

Source link: https://doi.org/10.1007/s43032-022-00903-4


A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways

In the United States' non-Hispanic Black population, pregnancy rates are disproportionately high. In addition, Black women are also vulnerable to certain environmental pollutants in adisproportionate manner. Non-Hispanic Black women's blood or urine were found at elevated rates in our blood or urine, relative to non-Hispanic White women. We tested 19 chemicals, which were found at higher rates in the blood or urine of non-Hispanic Black women than those who were not. From the Preterm Birth Database, we obtained chemical-gene interactions from the Comparative Toxicogenomics Database and a list of genes involved in preterm birth. The preterm birth genes were then enriched with pathways for the pre-birth gene in these pathways by using DAVID software, which then found chemical changes on gene expression in these pathways. Preterm birth genes were enriched for pathways including u201cinflammatory response, methylparaben, propylparaben, propyl paraben, methylparaben, diethyl phthalate, dichloroethylene, and bisphenol S. Preterm birth genes were affected by chemicals enriched with pre-term birth genes in both directions.

Source link: https://doi.org/10.1007/s43032-022-00870-w


The Effect of Preterm Birth on Maximal Aerobic Exercise Capacity and Lung Function in Healthy Adults: A Systematic Review and Meta-analysis

Background The negative effects of premature birth on adulthood's health are well established. However, it is not clear if healthy adults who were born prematurely but later had similar physical fitness levels when compared to adults who were born at term have a reduced maximal aerobic fitness capacity. In otherwise healthy, physically fit individuals, we wanted to find out the effect of premature birth on aerobic endurance and lung function. Conclusions Whilst the current literature contains mixed results regarding premature birth of V O_2max and FEV_1, our focused meta-analysis shows that even though physical activity levels are similar, there is a significant decrease in both V O_2max and FEV_1 in adults born prematurely, despite this. Therefore, future studies should thoroughly investigate the underlying determinants of the reduced V O_2max and FEV-1 in humans born preterm, and develop strategies to increase maximal aerobic capacity and lung function beyond physical activity interventions.

Source link: https://doi.org/10.1007/s40279-022-01710-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions