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Preterm Birth - Europe PMC

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Last Updated: 21 July 2022

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Preterm birth and postpartum depression within 6 months after childbirth in a Brazilian cohort.

Preterm birth and postpartum depression are common public health problems, and although literature mostly supports the link between them, several studies in this field have revealed methodological flaws, restricting the interpretation of such findings. This research sought to determine the connection between PTB and PPD by comparing groups of pregnant and full-term mothers in two Brazilian cities with contrasting sociodemographic characteristics. During pregnancy, breastfeeding, and the postpartum period, this prospective convenience cohort analysis examined 1421 women during pregnancy, birth, and the postpartum period. PPD was administered to assess PPD within six months after delivery, and women were expected to be depressed if scores were EDPS u2265 12. In two large samples from two Brazilian cities with contrasting socioeconomic status, the association between PTB and PPD was not established. Prenatal care should foster maternal mental stability in the hopes of reducing unfavored outcomes for mothers, infants, and families.

Source link: https://europepmc.org/article/MED/35849216


Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth.

Methods The total number of 302 pregnant women who attended our hospital from January 2019 to December 2021 were excluded, according to gestational days. SAA and IL-6 in the case group are higher than those in the control group, and the most practical value of SAA and IL-6 access SPB risk is 17. 35 million mL. Conclusions SPB risk by SAA and IL-6 is of uncertain clinical importance, and it may help clinicians identify and assess SPB risks, as well as clinicians in recognizing and assessing SPB risks.

Source link: https://europepmc.org/article/MED/35853546


Relationship between unremoved cervical polyp in pregnancy and spontaneous preterm birth.

Background Cervical polyps removed during pregnancy were thought to be related to preterm birth; however, the relationship between unremoved cervical polyps and preterm birth is still unclear. The study's scope This retrospective cohort study included pregnant women who visited a tertiary perinatal center before 12 weeks of gestation between January 2015 and December 2019. Relationships between cervical polyps and spontaneous preterm birth in the first 34 weeks of gestation were evaluated using logistic regression analysis and Cox proportional hazards analysis adjusted for common confounders of spontaneous preterm birth. Compared to those without polyps, the prevalence of spontaneous preterm birth during 34 weeks of gestation was higher in pregnant women with cervical polyps than those without. The adjusted hazard ratio for spontaneous preterm birth among women with cervical polyps was 2. 95 compared to placebo polyps.

Source link: https://europepmc.org/article/MED/35841937


Economic costs and health utility values associated with extremely preterm birth: Evidence from the EPICure2 cohort study.

Objectives: Using results from a whole population survey, it was difficult to assess economic outcomes at age 11 associated with high risk of premature birth. Methods The study population consisted of a sample of children born in England during 2006-to-date, as well as a comparison group of classmates born at term. Utility scores for the Health Utilities Index Mark 2 and Mark 3 were generated using UK and Canadian value sets. Results Unadjusted Mean Social Costs That Discontinued the provision of special educational assistance in mainstream schools in the 11th year after birth were u00a36536 for the very short term group and u00a33275 for their peers, making a difference of u00a332>. Compared to birth at term, extremely early birth resulted in mean-adjusted utility decrements ranging from 0. 13 based on the UK HUI2 statistical inference tariff to 0. 28 based on the Canadian HUI3 tariff.

Source link: https://europepmc.org/article/MED/35830294


Genetics, epigenetics, and transcriptomics of preterm birth.

Preterm birth plays a significant role in neonatal mortality and morbidity. A multitude of pathological conditions can contribute to a Spontaneous preterm birth. Although many non-genetic risk factors influence gestation and labour's timing, robust evidence supports the role of significant genetic and epigenetic factors as well as environmental influences that may influence sPTB. Several genes involved in the inflammation and immunity-related pathways that could influence sPTB were discovered in these studies. Also, new studies have pointed to the possibility of sPTB risk through epigenetic changes of gene expression by the environmental signals. Future genetic studies of sPTB should continue to explore the contributions of both maternal and fetal genomes, as well as their environment.

Source link: https://europepmc.org/article/MED/35818963


Biomaterial-based treatments for the prevention of preterm birth after iatrogenic rupture of the fetal membranes.

However, the iatrogenic preterm prenatal rupture of the fetal membranes, which can result in preterm birth, remains the most significant complication. Despite the reason for iPPROM's not being fully understood, the puncture created by the fetoscope remains unhealed until the end of the pregnancy, which allows for chorioamniotic separation and amniotic fluid leakage. We also systematically review and summarize the various techniques that have been tested to plug, seal, heal, or sue the FMs in preclinical and clinical studies and assess their strengths, findings, and future directions.

Source link: https://europepmc.org/article/MED/35699127


The causal and independent effect of ozone exposure during pregnancy on the risk of preterm birth: Evidence from northern China.

Our research sought to determine the appropriate time and location of an important window and determine the causal and independent effects of O3 exposure during pregnancy on the risk of premature birth. Through the inverse distance weighting system, we obtained the individual exposure for each subject during pregnancy in Jinan, northern China, based on the baseline population of the birth cohort. Through the time-dependent Cox proportional-hazard models, the effects of O3 exposure during pregnancy on PTB was investigated. 109. 51 m3/m 3 bcg/m 3 The median O3 concentration during pregnancy was 109. 51 u03bcg/m 3. Moreover, the O 3 estimated risk of PTB by the IV was 2. 63 percent, according to the IV. Therefore, the high prevalence of O3 exposure during pregnancy may raise the risk of PTB, which may be a causal cause.

Source link: https://europepmc.org/article/MED/35835165


Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis.

Background: The trade-off between comparative effectiveness and reproductive morbidity of different treatment techniques for cervical intraepithelial neoplasia remains unclear. We wanted to determine the risks of treatment failure and preterm birth with various healthcare techniques. Methods We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials database for randomised and non-randomized studies reporting on oncological or reproductive outcomes after CIN drugs from database start-up to March 9, 2022, without language restrictions, in this systematic review and network meta-analysis. Women with untreated CIN were also included in the network for preterm birth. We extracted group-level summary results from randomised controlled trials, and for observational studies, we extracted relative treatment effect estimates adjusted for potential confounders as available, and we did random-effect network meta-analysis to obtain odds ratios with 95% CIs. The network for treatment failure, which included 19 240 participants in 71 studies and the network for preterm birth, had 68 817 participants in 29 studies. The risk of treatment failure was reduced for other surgical techniques and increased for laser ablation and cryotherapy, compared to LLETZ. Direct results were based on two small studies only, and no differences were found for the comparison of cold coagulation versus LLETZ. Interpretation More modern excisional methods reduce the chance of treatment failure, but it does increase the risk of subsequent preterm birth. Patient Health: New Patient Benefits: National Institute for Health and Care Research: Patient Benefits (NICE) Funding for Patient Benefits The National Institute for Health and Care Research: Patient Benefits – Studies on Patient Benefits.

Source link: https://europepmc.org/article/MED/35835138


Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts.

Importance Phthalate absorption is common among pregnant women and may be a risk factor for preterm birth. Intention: Objective To determine whether there are any potential links between urinary biomarkers of phthalates in pregnancy and preterm birth among people living in the United States. Exposures Urinary phthalate metabolites were determined as biomarkers of phthalate exposure. With logistic regression, the relationship between the total mixture of phthalate metabolites and preterm birth was also investigated. In over 96 percent of participants, the majority of phthalate metabolites were detected. According to 1. 9, 5. 9, and 11. 1 preterm births, there were approximately 90 preterm births per 1000 live births in this study population, with proposed measures to reduce the mixture of phthalate metabolite levels by 10%, 30%, and 50%. Conclusions and relevance The findings from this large research group show that phthalate exposure during pregnancy may be a preventable risk factor for preterm delivery.

Source link: https://europepmc.org/article/MED/35816333


Platelet protease activated receptor 4 (PAR 4) Receptor Genotype is Associated with an Increased Risk of Preterm Birth.

Background Platelet protease activated receptor-4 Thr120 is a common genetic variant associated with elevated platelet production. Increased platelet activity has been implicated in the genesis of preeclampsia and preterm birth. Objective Compare the incidence of preeclampsia and preterm birth in pregnant women who are homozygous for the PAR4 Thr120 version vs. not. Study design This is a prospective cohort study of patients who lived between November 2020 and June 2021. On admission for PAR4 genotyping, maternal blood was obtained. The most significant result was the rate of preeclampsia/gestational hypertension in those with Thr/Thr genotypes compared to Ala/Thr or Ala/Ala. Those who Thrived to unborn preterm birth at an amputation rate of 34% vs. 3. 7 percent, aOR 4. 04, indicated preterm birth due to fetal growth restriction or preeclampsia, spontaneous preterm birth, and placental intervillous thrombosis. Conclusion Platelet receptor PAR4 Thr120 is a common variant found in homozygous individuals with an elevated risk of placental vascular pathology and preterm birth.

Source link: https://europepmc.org/article/MED/35815338

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions