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Preterm Birth - Crossref

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Last Updated: 21 July 2022

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Aeration Strategy at Birth Does Not Impact Carotid Blood Flow and Oxygen Delivery in Preterm Lambs

Background: The effects of various respiratory techniques at birth on the preterm lung are well understood, but fears of lung recruitment may impede cerebral haemodynamics have been raised. Overall, carotid blood flow tests were comparable between programs, with the exception of mean carotid blood flow, which was significantly lower for the SI group compared to the No-RM and DynPEEP groups respectively over the first three minutes.

Source link: https://doi.org/10.1101/2022.03.03.482754


Preterm birth: the impact of risk factors on pregnancy outcomes

AIM: The aim of this research was to determine the effect of risk factors on the outcome of threatened preterm birth. The main group, which included 68 women with preterm birth, was composed of 62 women with timely delivery. RESULTS: The results of preterm birth are adversely affected by overweight in the group of modifiable risk factors, prior birth in the immediate family in the group of non-modifiable risk factors, as well as other non-modifiable risk factors, as well as other unusual risk factors in the group of potentially modifiable risk factors.

Source link: https://doi.org/10.17816/jowd108233


The effectiveness of the Dr. Arabin cervical pessary in the prevention of extreme preterm birth and very preterm birth in twins

AIM: The aim of this research was to identify risk factors for spontaneous preterm birth and evaluate the efficacy of a cervical pessary in pregnant women with twins and a short cervix. RESULTS: After 16 pregnant women with induced preterm birth were rejected from further research, based on the pregnancy findings, all patients were divided into two main groups. In group I, the research was continued by 75 pregnant women, with term birth in 40 percent women in group I and spontaneous preterm birth in 35 women in group II. The average period of pregnancy extension was statistically different between groups II and I. In group I, the average gestational age of labor initiation was 37. 73 0. 62 weeks and 34. 24 weeks in group II, while group II had a median age of 37. 72 weeks. On a bimanual vaginal examination 20 mm, the Bishop's detailed review of pregnancy and labor in high-risk groups revealed two risk factors that could influence the occurrence of spontaneous preterm birth in twin pregnancies: the Bishop's score 5 points and cervical length were found on a 20 mm skeletonization study. CONCLUSIONS: The use of a cervical pessary in a group of pregnant women with twins and at a high risk of spontaneous preterm birth not only allows for pregnancy prolongation and excluding the birth of very premature babies, but it also reduces the number of spontaneous extreme and very preterm births.

Source link: https://doi.org/10.17816/jowd107434


Reductions in stillbirths and preterm birth in COVID-19 vaccinated women: a multi-center cohort study of vaccination uptake and perinatal outcomes

ABSTRACT BIOGRATHER In pregnancy, COVID-19 infection in pregnancy is linked to an elevated risk of development of severe disease, but pregnant women's vaccination intake is hampered by persistent safety concerns. All 12 public maternity hospitals in Melbourne's suburbs were extracted on births 2021 to 2022, with Routinely gathering data from 1 st. July 2021 to 31 March 2022. The Middle East, Africa, and Oceania had lower adjusted odds of vaccination than those born in Australia, women born in South and Eastern Europe, and infants born in Australia. Vaccination has been credited with a significant decrease in total preterm births 37 weeks, spontaneous preterm birth, and iatrogenic preterm birth were all associated with a dramatic decline in total preterm births. Conclusions COVID-19 Vaccine coverage was significantly affected by well-known health determinants of health, which is likely to influence the strong association between COVID-19 vaccination and reduced risks of infanticide and preterm birth. u2370 Most of the published research on COVID-19 vaccination in pregnancy has methodological issues, including fixed cohort bias and time-varying exposure. U2370 The adjusted odds of stillbirth, preterm birth, and neonatal intensive care admission were dramatically reduced among infants born to COVID-19-vaccinated women relative to unvaccinated women. U2370 Our research revealed a strong correlation between the COVID-19 mRNA vaccine and lower preterm births and stillbirths in our pregnant population. u2370 In addition to its benefits in lowering severe COVID-19 disease, vaccination may be a proxy for other socioeconomic and socioeconomic determinants of health in our pregnant population.

Source link: https://doi.org/10.1101/2022.07.04.22277193


Effectiveness of individualized lung recruitment strategies at birth: an experimental study in preterm lambs

While aeration is established, the simplest respiratory transition at birth involves rapidly clearing fetal lung fluid and preventing efflux back into the lung. In 127 a day preterm lambs, we measured the effect of each with a group managed with a PEEP of 8 cmH 2 O and no recruitment device. At the time of the study, molecular and histological markers of lung injury were analyzed. The improvement distal lung tissue aeration in SI OPT and OLV resulted in better oxygenation at 60 min, which translated into improved oxygenation at 60 minutes. If optimized, Tidal ventilation or an SI achieves similar aeration, implying that preventing fluid leakage after lung liquid clearance is at least as important as fluid clearance during initial inflation at birth.

Source link: https://doi.org/10.1152/ajplung.00416.2016


Characterization of murine amniotic fluid B cells in normal pregnancy and in preterm birth

Nevertheless, limited information regarding amniotic fluid B cells' phenotype and functionality is available. Hence, we wanted to perform a complete phenotypical and functional analysis of amniotic fluid B cells in normal pregnancy and in a mouse model of preterm birth. An immature population, resembling B1 progenitor cells, and a more mature population were shown by a phenotypic examination. The capacity of the immature B cells to mature was demonstrated by further isolation and in vitro co-culture with a bone marrow cell line. In addition, amniotic fluid B cells were increased in the acute phase of LPS-induced preterm birth. Overall, our findings reveal new insight not only into the amniotic fluid B1 B cells' phenotype and developmental stage, but also on their functionality.

Source link: https://doi.org/10.1530/rep-19-0150


Cervical remodeling in term and preterm birth: insights from an animal model

The process of preterm cervical ripening can vary from term ripening and assembly, leading to rapid changes to collagen fibril processing and assembly that result in tissue stiffness during pregnancy, 1 the finding that immune cells are not essential to cervical ripening can differ from term ripening and is dependent on the etiology of prematurity, according to 3 the discovery that early pregnancy changes in collagen fibril processing and assembly that result in rapid changes to collagen structure and assembly that result in ti eti ripening can vary from term ripening and is dependent on ripening determination and assembly that result in early embryo fibros and gradation rib re ribo ribon ripening throning etion e etio e etiaedio e etiaedo etiaetedo's etiae etioniaediaeti These results, which are relevant to human cervical biology, provide new insight into the human cervix, as well as potential biomarkers for early cervical ripening and delivery of new medications to minimize premature ripening of the cervix and subsequent preterm birth.

Source link: https://doi.org/10.1530/rep-11-0466


Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners

PTB risk was coincident with decreased placental progesterone receptor mRNA expression and increased toll-like receptor 4 mRNA expression, indicating that toxicant exposure triggered a heightened immune response at the maternalu2013fetal interface. Although PTB was present in control females mated to TCDD-exposed males on the same diet, fish oil supplementation of TCDD-exposed males removed PTB in unexposed males, it was not uncommon. We also determined the influence of preconception, paternal fish oil supplementation, on late pregnancy's placental inflammation response by analyzing the expression of Pgr and Tlr4 mRNA, as well as the presence of 15-hydroxyprostaglandin dehydrogenase. A significant rise in Tlr4 mRNA expression among TCDD-exposed males on the recommended diet revealed a significant rise in Pgr mRNA and PGDH protein levels in comparison to control pregnancies.

Source link: https://doi.org/10.1530/rep-11-0070


A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin

The cause of one-third of preterm births is preterm premature rupture of membranes. Preterm premature rupture of membranes in humans is related to Ehlersu2013Danlos syndrome. Since biglycan/decorin null mutant mice display phenotypic changes similar to EDS, we used this model to see whether either biglycan or decorin may have played a role in successful term gestation. The length of gestation, pup and placenta weight, and litter size were determined in a Wild-type biglycan null mutant, decorin null mutant, and largelycan/decorin null mutant pregnancies. In the absence of each other and tightly bound in fetal membranes, Biglycan and decorin were upregulated in the placenta, contributing to gestational development in a dose-dependent fashion, suggesting that these two proteoglycans demonstrate genetic complementation and contribute to gestational longevity in a dose-dependent manner. The biglycan/decorin null mutant mouse is a model of genetically induced preterm birth and perinatal loss.

Source link: https://doi.org/10.1530/rep-10-0387


Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats

In pregnant rats, animal experiments were conducted to see the effect of treatment with a selective COMT inhibitor on mifepristone-induced preterm birth and cervical resistance stretching. On day 1 and lowest on days 8 and 13, but higher numbers were returned by days 16 and 19 of pregnancy. When compared to the value of pregnant rats treated with mifepristone and COMT inhibitor alone, the percentage of pups retained in the uterus of pregnant rats treated with both mifepristone and COMT inhibitor was significantly higher. Compared to cervical tissues obtained from rats treated with vehicle control, the resistance to stretch was significantly higher in cervical tissues from the pregnant rats treated with COMT inhibitor.

Source link: https://doi.org/10.1530/rep-07-0245

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions