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PPD is undertreated in part because women are reluctant to seek medical attention due to stigma surrounding mental health care, logistical barriers to at-tending additional health care services, and a refusal to use medications while breastfeeding. The investigators produced a novel intervention based on the theory of maternal depression as a potential disorder of the mother-infant dyad, as well as one that can be treated by psychological and behavioral changes in the mother, which can impact both the mother and the baby. This research will determine if a behavioral intervention targeted maternal caregiving of young children can increase infant sleep and minimize fuss/cry behaviors, and in turn reduce the incidence and/or severity of postpartum maternal depression and subsequent child growth.
Source link: https://clinicaltrials.gov/ct2/show/NCT03283254
Both the mother and her baby seem to suffer as a result of untreated depression. Postpartum depression is extremely common among women with a history of depression. We're planning a research to see if trazodone in a low dose is more effective than a sugar pill in preventing postpartum depression among women with a history of depression. The findings of our report, we hope, will make it possible for healthcare professionals to choose the right medications for women who are at risk of experiencing depression after delivery, and thus improve mothers' emotional stability and well-being of their children.
Source link: https://clinicaltrials.gov/ct2/show/NCT05299398
After providing informed consent, women without bipolar, psychotic, or current substance use disorders, as well as borderline personality disorder are randomized 1:1 to the intervention or control group. Participants in the Intervention Group receive a 9-week on-line CBT group from Peer facilitators who have recovered from Postpartum Depression and have been trained to provide CBT. New mothers can also be receiving medical care as usual or typical care for new mothers from any source. Participants in the Control Group do not receive the CBT group but are given a list of mental health and postpartum depression services and are also encouraged to seek medical attention for new mothers from any source. Participants in the intervention program would also complete questionnaires at one point during the course of the probe and a satisfaction survey at the end of the program.
Source link: https://clinicaltrials.gov/ct2/show/NCT05044455
PPD's overwhelming majority of women with PPD receive psychotherapy as a 1st-line therapy, according to clinical practice guidelines. The aim of this pilot study was to successfully adapt and provide a 1-day CBT workshop for depression to women with PPD, establish the acceptability of a research protocol, and determine a prediction of the treatment effects in this population for a later, large-scale study. If this report shows that a one-day CBT workshop for PPD can be safely delivered to women, it will likely lead to the commencement of a larger trial aimed at establishing the effectiveness of teaching this 1-day CBT workshop to women with PPD. In addition to providing women with PPD with CBT skills at this critical time in life, the healthcare system can help prevent future depressive relapses.
Source link: https://clinicaltrials.gov/ct2/show/NCT03654261
To reduce women's symptoms, standard pharmacologic and psychological interventions are used to reduce women's symptoms of postpartum depression. Although maternal risk factors for PPD are well known, evidence based on commonly used depression treatments is only just starting to be investigated. Infant cry/fuss, and sleep habits are linked to PPD, according to studies, and parenting interventions can influence infant behavior, but these results have not been applied to PPD. The investigators intend to collect data on a new PPD risk-reducing strategy based on a dyadic behavioral approach to PPD in which the investigators treat at-risk women by promoting maternally-mediated behavioral changes in their infants. This research has the potential to have a major effect on clinical research and to advance PPD care in the sense that the protocol sessions can be integrated into routine perinatal medical visits, and that the prevention method will include neurobehavioral markers in the perine; this will lead to increased risk factors for PPD in the perine.
Source link: https://clinicaltrials.gov/ct2/show/NCT01379781
What are participants' experiences of the two intervention components - WBI and coaching - within 5 to 12 weeks of giving birth? i What are women's experiences of the WBI's usability in terms of the planning, navigation, and functionality at three months after randomization? The EPDS is the most commonly used outcome measure for depression, and the GAD-7 is the most common outcome measure for anxiety, and at the 3 and 6 month follow-up, what is the effect of coaching on the severity of depression and/or anxiety symptoms? What is the effect of training at 3 and 6 months on maternal health, parental anxiety, and six months on the use of mental health products, as well as barriers to using these services? With lay telephone coaching with two groups of women, one group of women was assigned to the WBI with training and the other to the self-guided WBI, the investigators will conduct a pilot single-blind randomized controlled trial. Screen women for RCT eligibility within 24 hours postpartum; Request informed consent to contact them again within 5 to 12 weeks postpartum; Screen women for RCT eligibility; Screen women for RCT screening; Follow-up at 6 months T2; and Follow-up at 6 weeks T2.
Source link: https://clinicaltrials.gov/ct2/show/NCT04073043
Women, their children, and society in the Czech Republic are still suffering from decades of primary research into complex adverse effects of postpartum mood disorders, however, as the results obtained from the study has not been translated into a systematic intervention. In the Czech Republic, the care of women suffering from postpartum mental disorders is fragmented, and not addressed in a step-by-step manner. Further, there is no program in the Czech Republic for the prevention of perinatal mental disorders in women, which also plays a preventive role in the development of mental disorders in the children of these mothers. Women at risk of PPD development are identified in maternity hospitals, according to the following METHODS Screening Phase, identifying women at risk of PPD development. Participants with an EPDS score of 10 will be sent an automatic email thanking them for participating in the study and informing them of a low risk of developing PPD. Participants have a higher risk of mental distress than others predicted during the evaluation, and therefore investigators provide advice on how to proceed if participants want to actively seek care. Each woman with EPDS 10 who will be randomized to the intervention team will be sent by the peer support coordinators to ensure the coordinator can connect the woman with the peer consultant. The change in the average cost of an alternative divided by the change in average benefits is measured, and very often investigators compare a new treatment with an existing one. The costs of the monitored treatment plans are determined by weighing the services provided to the patient for the year of monitoring by their price, i. e. The Czech Republic has extensive national registers of administrative data on the use of health services. Investigators will link clinical results from the intervention portion of the study to CEA results from the Institute of Health Information and Statistics of the Czech Republic, which has been affiliated with the Institute of Health Statistics and Statistics of the Czech Republic since 2016. In week six of Edinburgh Postnatal Depression Scale, the difference between group differences is evident in the analytic plan Primary outcome is the between group difference in the Edinburgh Postnatal Depression Scale. Investigators will use the ANCOVA test to determine the effects of intervention on the self-reported depressive signs. The RRs with 95% CI will determine the relationship between individual differences in the distribution of mental disorders assessed by the MINI interview process intervention as the RRs with 95% CI. The time will tell the differences over time will be determined by the interaction between group and time. According to a valid Czech payment statute, the estimation of health-care services and medications used will be made.
Source link: https://clinicaltrials.gov/ct2/show/NCT04639752
Postpartum depression affects up to 20% of women and has a major influence on women and their children. According to the majority of women with PPD receiving psychotherapy as a 1st-line therapy, and that screening should only be conducted in settings where CBT is readily available. The aim of this report is to apply task shifting to PPD diagnosis by determining if women with a long history of PPD living in the community can be trained to provide effective group CBT to women with current PPD. A CBT intervention for PPD has been developed and tested, as well as a training program that, according to pilot results, is capable of effectively training public health nurses with little background in psychiatric training. Recovering former patients' interventions, which Peer administered interventions, are increasingly recognized as alternative to traditional mental health care services as viable alternatives to traditional mental health care services. Satisfaction surveys are also comparable to traditional in-person psychotherapy. If lay peers can deliver effective group CBT for PPD, it will be determined if lay peers will provide valid group CBT for PPD by recruiting 174 women and using a random controlled trial scheme. If peers are conditioned to deliver effective CBT online, more women will receive medical attention, and the burden of PPD on women, families, and the healthcare system will be significantly reduced, as the healthcare industry will be greatly reduced. Providing women with PPD and CBT skills at this critical stage in life also has the ability to prevent future depressive relapse with significant benefits for patients, families, educators, and the healthcare system.
Source link: https://clinicaltrials.gov/ct2/show/NCT04913584
Esketamine has been approved by the FDA for the treatment of refractory and suicidal depression, but does it effectively prevent and treat postpartum depression? This report intends to investigate the preventive impact of prophylactic administration of esketamine on postpartum depression in the cesarean section, as well as evaluate the drug's safety.
Source link: https://clinicaltrials.gov/ct2/show/NCT04860661
Postpartum depression refers to maternal anxiety that began shortly after childbirth, with reported incidences ranging from 10% to 20%. Prenatal depression or high anxiety score is a risk factor in postpartum depression that has occurred on an independent basis. S-ketamine is more effective as an anaesthetic, and it may also have a greater antidepressive effect. Low-dose s-ketamine administered after childbirth can reduce the risk of postpartum depression in parturients with prenatal depression, according to the study's objective.
Source link: https://clinicaltrials.gov/ct2/show/NCT03927378
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