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"The hypothesis that ketamineu2019s antidepressant and anti-suicidal device can be in part due to its procognitive role in comparison to the well-established low results on spatial working memory and pattern recognition among long-term frequent users. " We wanted to investigate the neurocognitive effects of subanesthetic doses of intravenous ketamine in pharmacological studies among healthy subjects and patients with PTSD or depression. In comparison to the immediate improvement of cognitive function in healthy subjects, ketotamine treatment among patients with depression and possibly with PTSD does not result in significant impairments of cognitive function in the short term. The potential cognition benefits of ketamine in cognitive domains of executive function, which are in accordance with the putative molecular, cellular, and synaptic pathways of ketamine's therapeutic function, are getting more apparent in cognitive domains of executive function. Conclusions The potential procognitive use of ketamine warrants further study. ketamine's increased cognition may be able to support psychotherapy services for PTSD and depression.
Source link: https://doi.org/10.1007/s40261-022-01169-z
"Purpose Examine SSRI's U2019 effectiveness in treating depression, anxiety, PTSD, and heroin use in individuals with addiction" is a problem. " The Bayes factor in establishing efficacy and tau statistical heterogeneity established by the Bayes factor established efficacy and tau determinacy. We conducted 64 RCTs with 6128 participants, which revealed the following information. SSRIs reduced depressive signs in opioid, alcohol, cocaine, hemp, and nicotine use disorders; social anxiety about alcohol use disorder versus alcohol use disorder; and generalized anxiety problems in opioid, alcohol, cocaine, potassium, and nicotine use disorders — sedient, opium, nicotine, cannabis, and nicotine use disorders — skepticism in opioid, alcohol, cocaine, marijuana, and nicotine use disorders; and nicotine use disorders exacerbated by nicotine use disorders; and nicotine, There was no evidence for PTSD, and it was inconclusive. SSRIs enabled abstinence for opioid, cocaine, and nicotine use; reduced craving for alcohol, cocaine, and nicotine use; and reduced cocaine use and cocaine use; and reduced cocaine use and cocaine use – smuggling has been reduced. Fluoxetine had the most antidepressant activity when tested. There was no effect of attrition rate, SSRI dose, or treatment length on SSRI's effectiveness, according to the authors. Conclusions The use of SSRIs to treat drug use, depression, and anxiety in individuals with addiction are all supported by the research. CRD42020164944": Protocol registration Number: CRD42020164944.
Source link: https://doi.org/10.1007/s00228-022-03303-4
"The sample contained 111 male active service members of the Polish Police Department. " The study found that statistically significant, barely negative correlations between post-traumatic stress disorder symptoms and social help/care, as well as moderately positive connections between the traditional male role norms and post-traumatic stress disorder symptomatology variables. The intergroup differences between the police officers who follow the PTSD guidelines and those who do not meet the requirements were mostly observed in complying with the established masculinity guidelines, in which the police officers with suspected post-traumatic stress disorder had higher success than those without; the reverse was observed in the case of social relations/help. However, only socioeconomic status norms, age, social networks/support, and a variety of other aspects of traumatic life disorder were found to be significant predictors of post-traumatic stress disorder, accounting for 55% of post-traumatic stress disorder symptoms.
Source link: https://doi.org/10.1007/s11896-021-09438-x
"Background People with psychosis have high rates of anxiety, with a post-traumatic stress disorder prevalence of about 15% that exacerbates psychotic signs such as delusions and hallucinations. " This trial, the largest to date, will determine the clinical results of a TF therapy integrated with cognitive behaviour therapy for psychosis in people with psychosis. The secondary objectives are to compare groups on cost-effectiveness; determine whether TF-CBTp has an effect on a variety of other important outcomes; and determine whether therapy effects persist; and determine acceptability of the therapy in participants and therapists. Adults with distressing post-traumatic stress and psychosis signs from five mental health Trusts will be randomised to the two groups. From 9 m and 24 m assessment points to gather service use over the previous three months, four 3-monthly phone calls will be made between 9 m and 24 m assessment points.
Source link: https://doi.org/10.1186/s13063-022-06215-x
"Veterans of post-traumatic stress disorder suffer often have psychological and physical comorbidities, increasing the risk of general and psychotropic polypharmacy. " This report explores the prevalence of general and psychotropic polypharmacy in inpatient veterans of post-traumatic stress disorder, as well as potential risks associated with polypharmacy in this population. Methods The medical records of 219 veterans admitted to a mental health center for post-traumatic stress disorder treatment were retrospectively reviewed. 90 percent had a diagnosis of at least one other mental disorder, 90. 9% had a diagnosis of at least one other psychiatric disorder, and 96 percent had at least one non-psychiatric medical disorder. The prevalence of general polypharmacy was 77%, psychotropic polypharmacy was 79. 9%, and sedative polypharmacy was 73%. Conclusions This cohort of inpatient veterans of post-traumatic stress disorder had a high incidence of general, psychotropic, and sedative polypharmacy, and was at a high risk for drug-related adverse events. ".
Source link: https://doi.org/10.1007/s40801-022-00298-3
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