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Post-Traumatic Stress Disorder - Europe PMC

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Last Updated: 12 June 2022

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A Systematic Review of Neurocognitive Effects of Subanesthetic Doses of Intravenous Ketamine in Major Depressive Disorder, Post-Traumatic Stress Disorder, and Healthy Population.

"The contention that ketamine's antidepressant and anti-suicidal function may be in part due to its procognitive effect and poorer pattern recognition memory among long-term regular users. " In pharmacological research involving healthy subjects and patients with PTSD or depression, we wanted to investigate the neurocognitive effects of subanesthetic doses of intravenous ketamine in subanesthetic ketamine. In comparison to the immediate cognitive impairment present in healthy patients, ketotamine treatment among patients with depression and possibly with PTSD does not cause significant impairment of cognitive function in the short term. The potential cognitive benefits of ketamine in cognitive domains of executive function, which is in accordance with the putative molecular, cellular, and synaptic mechanisms of the drug's therapeutic properties, are getting more apparent. Keamine improves cognition, which may be used to facilitate psychotherapy interventions for PTSD and depression.

Source link: https://europepmc.org/article/MED/35672558


Oral and Dental Considerations of Combat-Induced Post Traumatic Stress Disorder (PTSD)-A Cross-Sectional Study.

"Objective" The study compared dental, periodontal, oral, and joint/muscle tenderness among Israeli combat-induced post-traumatic stress disorder war veterans to non-PTSD veterans. Study design This three-arm research compared oral and facial characteristics of 100 Israeli veterans with Ci-PTSD and 103 non-PTSD patients. In the PTSD group compared to the control group, the plaque index was higher than in the control group. Compared to the nonmedicated group and the controls, severe periodontal disease was more prevalent among the PTSD subgroup taking medications than those taking medications. Heavy smoking was more prevalent in the medicated PTSD patients than in other groups.

Source link: https://europepmc.org/article/MED/35683634


Oxytocin receptor gene, post-traumatic stress disorder and dissociation in a community sample of European American women.

"The aim of this research was to investigate whether oxytocin receptor gene single nucleotide polymorphisms with post-traumatic stress disorder and dissociative symptoms, as well as gene-environment interaction with childhood maltreatment. " These findings support theorizing and evidence indicating that the oxytocin system and its genetics may be associated with a risk of dissociation among European American women, especially those with maltreatment history. ".

Source link: https://europepmc.org/article/MED/35656579


Combining Trauma Script Exposure With rTMS to Reduce Symptoms of Post-Traumatic Stress Disorder: Randomized Controlled Trial.

"We decided to promote fear of extinction by combining trauma script exposure with repetitive transcranial magnetic stimulation to reduce symptoms of PTSD. " In patients with PTSD, the efficacy and safety of 10 Hz rTMS of the right dorsolateral prefrontal cortex were studied alongside exposure to personal traumatic history. Patients were randomly assigned 1:1 to eight daily sessions of 110% of motor threshold high frequency 10 Hz rTMS or 70% low frequency 1 Hz rTMS with trauma script exposure in both groups. Results Thirty-eight patients were randomly assigned to 11% HF rTMS or 70% LF rTMS, according to the author's report. Mean CAPS scores dropped by 51% in the 110% HF group and 36. 9% in the 70% LF rTMS group, but there was no significant change in change" from baseline to three months, but with no change in change.

Source link: https://europepmc.org/article/MED/35667770


Trauma-Integrated Mindfulness-Based Relapse Prevention for Women with Comorbid Post-Traumatic Stress Disorder and Substance Use Disorder: A Cluster Randomized Controlled Feasibility and Acceptability Trial.

"Background: Women receiving substance use therapy are typically affected by comorbid post-traumatic stress disorder and heroin use disorder. " SUD women have shown results with mindfulness-based relapse prevention, although it does not specifically mention PTSD. The limited availability of PTSD-SUD services for women may be addressed by integrating trauma-focused and gender-responsive therapies into MBRP. Methods: In a case where women with PTSD-SUD were denied TI-MBRP or MBRP, a single-blind computer-generated cluster-randomized scheme was used. Participants responded well; however, attrition was high at the 12-month follow-up. In the MBRP's first-month and 1-month follow-up, there were more reductions in PTSD severity and craving over the 12-month period in both conditions, as well as in the TI-MBRP group at the postcourse and 1-month follow-up, with significant declines in PTSD severity and craving. While MBRP alone may be most helpful in reducing both PTSD and SUD symptoms in women with PTSD-SUD, cautioning that confirmatory studies are warranted. ".

Source link: https://europepmc.org/article/MED/35648046


Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms.

"Introduction Posttraumatic stress disorder is a psychological disorder that has arisen from exposure to violent events. " Psychotherapies are helpful in reducing PTSD symptoms, but after treatment, two-thirds of veterans are expected to meet diagnostic criteria for PTSD, implying that there is an incomplete picture of what causes PTSD. This study explored intestinal readouts in patients with PTSD. The intestine can influence the brain, and this research found intestinal readouts in patients with PTSD. Methods Comparing blood samples from controls without PTSD from the Duke In-Trust Program to veterans with PTSD acquired from Rush University Medical Center's Road Home Program. In addition, intestinal readouts were tested in PTSD patients before and after a 3-week CPT-based intensive rehabilitation program to find out if treatment affects the intestine. Conclusions "The intestine is abnormal in subjects with PTSD, and it is found that efficient therapy of PTSD does not improve intestinal readouts. ".

Source link: https://europepmc.org/article/MED/35638693


Post-Traumatic Stress Disorder and Coping Strategies Among People with HIV in Lira District, Uganda: A Cross-Sectional Study.

"Background Post-traumatic Stress disorder is the most common reported mental health symptom following traumatic events" "Background Post-traumatic stress disorder is the most commonly reported mental health complication following traumatic events. " However, little is known about how people with HIV cope with the PTSD burden in Lira, northern Uganda, although it is unknown how people with HIV cope with the PTSD burden. Compared to those who planned activities, individuals who did not use planning as a coping tactic had more than twofold increased risk of experiencing PTSD than those who did not. Compared to those that had emotional support, participants with no emotional assistance had a nearly three-fold greater risk of experiencing PTSD. Conclusion : The PTSD burden among HIV patients attending health center IVs in Lira District was noticeably higher, and it was largely related to gender, planning, emotional assistance, and spirituality. In addition, there's also a need to include PTSD treatment services in the treatment program of HIV care services in Lira District.

Source link: https://europepmc.org/article/MED/35669392


The Relationship between 9/11 Exposure, Systemic Autoimmune Disease, and Post-Traumatic Stress Disorder: A Mediational Analysis.

"The relationship between 9/11 exposure, systemic autoimmune disease, and mental stability is vague," the author notes. This paper expands on a previous investigation by World Trade Center Health Registry results to see whether 9/11 exposure is a risk factor for SAD, and if so, whether post-traumatic stress disorder is a mediating factor, and whether the relationship varies based on responder/community member status. To determine the connection between 9/11 exposure and PTSD and SAD, logistic regression models were developed. The odds of SAD were 1. 85 times higher in the pooled cohort than those with 9/11-related PTSD. Among responders, those with dust cloud exposure had almost doubled the chances of SAD, while community members, those with 9/11-related PTSD, had 2. 5 times the chances of SAD. Although new evidence shows that 9/11 exposure can be related to SAD, more research is required, particularly using pooled data from other 9/11-exposed cohorts to properly describe this relationship. ".

Source link: https://europepmc.org/article/MED/35682106


Evidence for altered neural activity patterns after MDMA-assisted therapy in adults with chronic and severe post-traumatic stress disorder: a pilot study

"MDMA is believed to facilitate the therapeutic process, in part by lowering anxiety response during fear memory processing while increasing extinction learning retention. " The amygdala and hippocampus are among the brain regions involved in the hyperactive fear response to PTSD. The injection of MDMA in healthy controls improves recruitment of brain regions involved in the hyperactive fear response in PTSD. We analyzed brain function and connectivity during both rest and autobiographical memory recall responses before and two months after MDMA-AT treated PTSD in nine veterans and first-responders.

Source link: https://europepmc.org/article/PPR/PPR499295


A Public Health Perspective of Post-Traumatic Stress Disorder.

"Trauma exposure is one of the most common and common risk factors for mental and physical health. " Prolonged or heavy stress exposure raises the risk of a variety of mental and physical disorders, resulting in a condition known as post-traumatic stress disorder. This literature review provides a preview of up-to-date research on traumatic stress, with a focus on causes or sources of distress, factors that influence response to stress, disease burden, and the use of the social-ecological public health model of disease prevention.

Source link: https://europepmc.org/article/MED/35682057

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions