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"Abstract Position Effect Variegation is a phenomenon in which the expression of a gene strongly depends on its genomic location. " When a gene is relocated by a chromosome rearrangement or identical genetic constructs are introduced into specific regions of the genome, PEV can be identified. The eukaryotic genome has a domain structure, and gene expression within a domain is not limited not only by the nucleotide sequence of a gene but also the state of surrounding chromatin, which is also controlled epigenetically. chromatin's epigenetic status is dependent on the replication time of a given genomic location, particular regulatory DNA motifs, and contacts with the inner nuclear envelope and other chromosome regions. Understanding the cellular chemistry of PEV in humans is of clinical significance, in particular for the detection and treatment of retroviral infections because the local chromatin state can determine the latent/active state transition of an infection, such as HIV. ".
Source link: https://doi.org/10.1134/S0026893322030049
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