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Polycystic Ovary Syndrome - Springer Nature

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Last Updated: 20 September 2022

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Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial

BACKGROUND PUSHES 0 - Our goal was to provide scientific evidence comparing the effect of oral probiotic therapy in patients with polycystic ovary syndrome in an Iranian population with letrozole therapy. In group B, letrozole, a drug acetate administered 2. 5 days from the third day of the menstrual cycle for 5 days in the second month. According to determine sexual function and body satisfaction, respectively, the Female Sexual Function Index and Body Image Concern Inventory were used to assess sexual development and body satisfaction. Results After intervention, Probiotic plus letrozole group has an increasing rise in chemical pregnancy rate and clinical pregnancy in comparison to the letrozole group. Conclusions of the current study report show that eight weeks of probiotic therapy may raise chemical and clinical pregnancy rate, sexual function, and body satisfaction in women with PCOS.

Source link: https://doi.org/10.1186/s12905-022-01955-z


Is early-follicular long-acting GnRH agonist protocol an alternative for patients with polycystic ovary syndrome undergoing in vitro fertilization?

Background We aimed to compare the clinical and perinatal outcomes of patients with polycystic ovary syndrome treated in vitro fertilization/intracytoplasmic sperm injection therapy with either a early-follicular long-acting hormone agonist long protocol or a midluteal short-acting GnRH-a long protocol. However, the number of patients u201cfreezing all''> for elevated risk of ovarian hyperstimulation syndrome and ectopic pregnancy was lower in the EFLL group than in the MLSL group. The incidence of gestational diabetes was higher in the EFLL group than in the MLSL group. The early-follicular long-acting GnRH agonist long protocol can be used as an ideal assisted reproductive technology pregnancy support service for patients with PCOS, but obese patients should be encouraged to shed weight before ART therapy to reduce the risk of GDM.

Source link: https://doi.org/10.1186/s12958-022-01007-z


The effect of hyperandrogenism and obesity on mindfulness and metacognition in adolescents with polycystic ovary syndrome

The aim of this research was to find out whether serum androgen levels had an effect on attention and metacognition in adolescents with polycystic ovary syndrome (PPOS). The Mindful Attention Scale and the Metacognition Scale Child and Adolescent Form were both asked to complete a questionnaire that contained socio-demographic data as well as two scales: the Mindful Attention Scale and the Metacognition Scale Child and Adolescent form. Mindfulness levels were also lower for obese patients with PCOS than to non-obese patients with PCOS. The PCOS's high serum androgen levels had no effect on mindfulness, but as the updated Ferriman Gallwey score increased, mindfulness levels decreased. Examine mindfulness in PCOS patients with increased hair growth and metacognition, according to the current research, can contribute to improved adulthood by lowering the emotional burden caused by the disease.

Source link: https://doi.org/10.1007/s00737-022-01264-2


Integrated bioinformatics analysis and screening of hub genes in polycystic ovary syndrome

Using the DESeq package, three gene expression profil datasets were found in PCOS and normal groups with an adjusted p -value 1. 2 were first discovered using the DESeq package. Clusters of tightly linked genes or modules associated with PCOS were found using the weighted correlation network analysis R package, which was used to identify clusters of highly correlated genes or modules associated with PCOS. The genes that were overlapping between the main module genes and PCOS-associated genes were also investigated.

Source link: https://doi.org/10.1007/s12020-022-03181-x


Tear film impairment and meibomian gland loss in patients with polycystic ovary syndrome

Objectives of this prospective research The aim of this prospective review is to determine the tear film, meibomian gland, cornea, and anterior chamber parameters, as well as subjective ocular symptoms in patients with polycystic ovary syndrome and healthy control subjects. We included 53 eyes of the 53 healthy control patients with PCOS and 57 eyes, none of the following scientific reports on male pattern hair loss, hirsutism or acne, and with regular menstrual cycles, none of the following research of male pattern hair loss, hirsutism or acne, and those with regular menstrual cycles, who have no laboratory findings indicating hypertension, and women with normal ovaries appear to be normal ultrasonographically, including hemochromatooo Mean non-invasive first tear film breakup times values for PCOS group and controls were 6. 15 u00b1 4. 48 and 10. 48 s, respectively; both cases indicate a substantial difference between the two groups. Patients with abnormal OSDI scores in the PCOS group were significantly higher than in controls. Conclusions of this report revealed that tear film stability was affected by PCOS-inhibition patients, and that this illness was accompanied by the loss of MG, which plays a significant role in tear film stability.

Source link: https://doi.org/10.1007/s10792-022-02479-z


The effect of metformin treatment on leukocyte telomere length in patients with polycystic ovary syndrome: a prospective case–control study

Purpose The aim of this review was to investigate the effects of metformin treatment on leukocyte telomere length and the relationship of LTL with C-reactive protein, homocysteine, albumin, complete blood count, and HOMA-IR values in patients with polycystic ovary syndrome. Material and method The research was conducted in a prospective case-u2013control study involving 30 women with PCOS and 30 healthy women without PCOS was done. For three months, PCOS patients were treated with metformin.

Source link: https://doi.org/10.1007/s10815-022-02577-y


Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies

Polycystic ovary syndrome, a common disorder that affects childbearing-age women, is linked to reproductive and metabolic disorders. All original animal studies and RCTs examining the effects of resveratrol on PCOS were eligible for the investigation. The beneficial effects of resveratrol on the histomorphological characteristics, sex hormones, and gonadotropins, were found in most of the included animal studies, including oxidative stress, inflammation, and oxidative stress. Resveratrol has also improved ovarian volume, high-quality oocyte rate, high-quality embryo rate, and high-quality embryo rate, and, as a result of endoplasmic reticulum stress in PCOS patients. The current literature is limited to report the benefactors of resveratrol on PCOS management. Nevertheless, resveratrol may be an excellent phytochemical in PCOS monitoring, particularly in hormonal and reproductive abnormalities, according to the promising findings of the animal studies and limited RCTs.

Source link: https://doi.org/10.1007/s43032-021-00653-9


A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome

After an oral glucose challenge, HbA_1c and PCOS, all in populations of European ancestry, were used, summarized results from the hitherto largest genome-wide association studies on type 2 diabetes, type 2 diabetes mellitus adjusted for BMI, fasting glucose, and 2h glucose, according to 2h glucose. Conclusions An improved overall genetic correlation between type 2 diabetes and PCOS was found, largely influenced by BMI but also independent of BMI. Type 2 diabetes/T2DM_adjBMI and PCOS were found in type 2 diabetes/T2DM_adjBMI_adjBMI_adjBMI and PCOS-targeted tissues of the cardiovascular, exocrine/endocrine, and digestive organs. Fasting insulin-adjusted for BMI and type 2 diabetes on PCOS was demonstrated by a putative causal connection. Our findings reveal the importance of monitoring type 2 diabetes in all women with PCOS, regardless of BMI, regardless of BMI.

Source link: https://doi.org/10.1007/s00125-022-05746-x


Serum-Derived Exosomal microRNAs in Lipid Metabolism in Polycystic Ovary Syndrome

Obesity and insulin resistance in polycystic ovary syndrome can be related to miRNA regulation that has been obscured by exosomes. In mice with dehydroepiandrosterone and a high-fat diet, a PCOS with IR was created. By qRT-PCR, the expression of miR-20b-5p and miR-106a-5p in serum exosomes was determined by qRT-PCR. In a PCOS model with IR, the effects of serum exosomal miR-20b-5p and miR-106a-5p on lipid metabolism and ovary histological structure were also investigated. Serum exosomal miR-20b-5p and miR-106a-5p overexpression may reduce adipocyte differentiation in 3T3-L1 cells with a IR and PCOS mice model. The miR-20b-5p and miR-106a-5p levels were markedly reduced in DHEA + HFD serum-derived exosomes. In 3T3-L1 cells and liver steatosis in mice, miR-20b-5p and miR-106a-5p overexpression increased adipocyte differentiation and triglyceride content, as well as liver steatosis. MiR-20b-5p and miR-106a-5p estimated targets, according to bioinformatics' analysis of miR-20b-5p and miR-106a-5p suggested that lipid metabolism was highly related to lipid metabolism.

Source link: https://doi.org/10.1007/s43032-022-00930-1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions