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Polycystic Ovary Syndrome - Europe PMC

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Last Updated: 20 September 2022

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Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis.

We investigated the effect of Apigenin in a rat model of polycystic ovarian syndrome here. Methods Female Sprague Dawley rats were treated with Dehydroepiandrosterone, one of the post-pubertal approach to creating a rat model of polycystic ovarian syndrome, Metformin was used as standard. Unlike control rats, Apigenin treatment improved the body mass and anti-oxidant status, decreased ovarian diameter, cysts, and restored the healthy follicles. In addition, the treatment of Apigenin reduced the incidence of oestradiol and testosterone in comparison to the control group, as well as, elevated levels of progesterone in the Apigenin-treated group of rats. Apigenin's effects were similar to that of standard drug Metformin, to a certain extent. Conclusions (PCOS rats): Apigenin ameliorates the affected hormonal balance, lipid profile, and antioxidant status, according to the study.

Source link: https://europepmc.org/article/MED/35152800


Genetic associations with polycystic ovary syndrome: the role of the mitochondrial genome; a systematic review and meta-analysis.

Background Polycystic ovary Syndrome is the most common female reproductive endocrine disorder. Genetic studies have largely concentrated on the role of the nuclear genome, though the role of mitochondrial genetics in PCOS remains largely unknown. Aim This article aims to review the literature on the connections between the mitochondrial genome and PCOS. Methods An literature search focused on PCOS and mitochondrial genetics was conducted on MEDLINE, EMBASE, and The Cochrane Library. In the ND5, A6 and 7 transfer RNA-coding genes, women with PCOS showed elevated rates of a 9 bp deletion and aberrant single nucleotide polymorphisms. They also found lower frequencies of two SNPs in the genome's D-loop. Women with PCOS also had a significantly reduced mtDNA copy number, which was also shown by a significant decrease in the number of mtDNA copies. Women with PCOS have genetic variations in coding and non-coding regions of the mitochondrial genome, which leads to the conclusion that women with PCOS have genetic variations in coding and non-coding regions of the mitochondrial genome.

Source link: https://europepmc.org/article/MED/36113966


A Global Survey of Ethnic Indian Women Living with Polycystic Ovary Syndrome: Concerns, Diagnosis Experiences, Quality of Life, and Use of Treatment Methods

Background: Polycystic ovary syndrome is a common endocrinopathy that is particularly prevalent in women of Indian ethnicity. Women with PCOS are vulnerable to cultural inequalities in the care of women with PCOS, according to the clinical practice guidelines. This report was designed to investigate ethnic Indian women's experiences with PCOS diagnosis and management, their fears, and it's effects on their quality of life. Methods: A global online survey of ethnic Indian women of reproductive age with PCOS shows that they are among the majority of female women of reproductive age living with PCOS. Women waited one year on average before undergoing medical intervention after symptom onset. Their three top issues were: irregular periods, cysts on the ovaries, and excessive facial hair growth. Conclusions: Ethnic Indian women wait for a long time before requesting medical assistance for PCOS, have poor QoL relating to weight and mental stability, and are dissatisfied with the diagnosis and support available at diagnosis.

Source link: https://europepmc.org/article/PPR/PPR546623


Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model.

Background, Polycystic ovary syndrome (POG) syndrome is a common cause of infertility in women of reproductive age around the world. Objects The current research was intended to investigate the protective effects of PCOS rats induced with letrozole. Methods Thirty-two female rats were randomly divided into four groups: control, PCOS, PCOS+5 mg/kg thymoquinone, and PCOS+10 mg/kg thymoquinone. Rats' thymoquinone administration reversed the most detrimental effects of PCOS on ovaries and sexual hormones. Conclusions These results indicate that thymoquinone has increased effects on ovarian function in the PCOS rat model. Therefore, thymoquinone can be useful as both a security agent and adjunct therapy in PCOS patients.

Source link: https://europepmc.org/article/MED/36104839


Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials.

Context The effects of nutritional therapy on various health conditions in women with polycystic ovary syndrome have been documented. Numerous meta-analyses have been published on the effects of various health problems in women with polycystic ovary syndrome. This umbrella study was designed to summarize the effects of nutritional interventions on women with PCOS and evaluate the validity of the evidence. Data extraction Meta-analysis was conducted on randomized clinical trials that looked at the effects of diet changes or supplements on women with PCOS. Women with PCOS who have significant differences in anthropometric and metabolic characteristics have significant improved some anthropometric and metabolic profiles. Lower carbohydrate, Dietary Interventions to Stop Hypertension, or Lower glycemic index/load diets in women with PCOS had significant reductions in certain anthropometric and metabolic characteristics. In uterine women with PCOS, inositol raised the ovulation rates. Conclusion There is no evidence that diets alone in women with PCOS improved health or reproductive outcomes, according to the study. Probiotics/synbiotics may reduce total testosterone, but inositol induces ovulation in women with PCOS. No. offenders for PROSPERO registration No. 74 years ago no. PROSPERO registration No.

Source link: https://europepmc.org/article/MED/36099162


Potential roles of genistein in polycystic ovary syndrome: A comprehensive systematic review.

Polycystic ovary syndrome is one of the most common polygenic endocrine disorders in reproductive-age women. Genistein is a soy-isolated phytoestrogen and isoflavone with antioxidant, anti-inflammatory, estrogenic, and antineoplastic activity. This systematic review was designed to investigate the therapeutic consequences and mechanisms of genistein's PCOS' actions. Geneistein's effects on PCOS were investigated by studies published in English, as well as its associated disorders. Out of 298 records reviewed, only 13 articles met the inclusion criteria: Nine animal and four human studies. According to the current analysis, genistein supplementation may help PCOS-related symptoms by lowering insulin resistance and anthropometric indices, improving ovarian morphology, and regulating reproductive hormones, and minimizing oxidative stress and inflammation by influencing biological pathways. Hence, this report shows that genistein can be regarded as a safe agent. However, additional research is needed to reach a general conclusion on the exact mechanism of genistein in PCOS patients.

Source link: https://europepmc.org/article/MED/36108737


Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.

Background: Our aim was to analyze the effect of oral probiotic therapy in patients with polycystic ovary syndrome (PCOS) treated with letrozole in an Iranian population considering the presence of sexual dysfunction in patients with polycystic ovary syndrome. In group B, letrozole, a drug used in group B, started 2. 5 days from the third day of the menstrual cycle for five days in the second month. Probiotic plus letrozole group has a statistically significant rise in chemical pregnancy rate and clinical pregnancy in comparison to the letrozole group after intervention. Compared to the letrozole alone group, the probiotic plus letrozole group's results had a significant rise in the FSFI domains and sum score after eight weeks. Conclusions of the current report show that eight weeks of probiotic administration may increase chemical and clinical pregnancy rate, sexual function, and body joy in women with PCOS.

Source link: https://europepmc.org/article/MED/36096842


Depression, anxiety, body image scores, and sexual dysfunction in patients with polycystic ovary syndrome according to phenotypes.

Background: Polycystic ovary syndrome has been attributed to both mental and metabolic disturbances. Results: Significantly higher BDI, HADS depression, and GHQ scores, as well as a more negative body image in terms of BCS scores were found in the women with PCOS than in the healthy controls. In terms of HADS depression and GHQ ratings, significant differences were only found between phenotype A and the control group. In Female Sexual Function Index scores between the PCOS phenotypes and the healthy controls, no significant difference was found. When all participants were divided into three groups based on body mass index, a statistically significant difference was observed only between the phenotype A lean group and the control group in terms of BDI, HADS depression, and BCS scores. Conclusions: BDI, HADS depression scores, and GHQ were all higher in patients with PCOS than in healthy controls.

Source link: https://europepmc.org/article/MED/36093888


Is early-follicular long-acting GnRH agonist protocol an alternative for patients with polycystic ovary syndrome undergoing in vitro fertilization?

Objectives: We wanted to compare the clinical and perinatal outcomes of patients with polycystic ovary syndrome undergoing in vitro fertilization/intracytoplasmic sperm injection therapy with either a early-follicular long-acting hormone agonist long protocol or a midluteal short-acting GnRH-a long protocol. However, the number of patients "freezing all" for elevated risk of ovarian hyperstimulation syndrome and ectopic pregnancy in the EFLL group was lower than in the MLSL group, indicating that the risk of ovarian hyperstimulation syndrome and ectopic pregnancy was smaller in the EFLL group than in the MLSL group. In the EFLL group than in the MLSL group, gestational diabetes was higher than in the MLSL group. The early-follicular long-acting GnRH agonist long protocol can be used as an ideal assisted reproductive technology pregnancy care service for patients with PCOS, but obese patients should be encouraged to shed weight before ART therapy to minimize the risk of GDM.

Source link: https://europepmc.org/article/MED/36088329

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions