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Polycystic ovary syndrome is a common disease that affects 88%u201313% of females of reproductive age, impinging their fertility and long-term health. The pivotal role of gut microbiota in metabolism has been increasingly discussed lately. Although the abnormalities in gut microbiota and metabolites may not be the root cause of PCOS' initial causes, they can play a key role in PCOS' pathological process. PCOS progression can be influenced by the dysbiosis of gut microbiota and gut metabolites. In comparison, PCOS can adversely influence the function of gut, thus contributing to the disease's progression. However, the role of gut microbiota in PCOS has yet to be fully investigated. This paper aims to discuss the potential effects and modulative mechanisms of the gut metabolites on PCOS and suggests future intervention targets, possibly providing more potential treatment options for PCOS in the future.
Source link: https://doi.org/10.3389/fendo.2022.933110
Androgens play a bidirectional role in the emergence of IR, and there is a complex interplay between IR and androgen excess in women with PCOS. Skeletal muscle maintains metabolic homeostasis while also being a metabolic target organ of androgen action. In the pathogenesis of metabolic disease in PCOS, skeletal muscle, androgen excess, and mitochondrial dysfunction are all increasing relevant. In this review, we intend to investigate the role of skeletal muscle in metabolism, focusing specifically on changes in skeletal muscle specific to PCOS, as shown in recent molecular and in vivo human studies. Despite increasing concern in the area of skeletal muscle dysfunction in women with PCOS, significant challenges and unanswered questions remain, and forward, new innovative techniques will be required to dissect the underlying mechanisms.
Source link: https://doi.org/10.1177/20420188221113140
Polycystic ovary syndrome is a common, complicated, and heterogeneous endocrine disorder of women that is caused by a combination of environmental and genetic factors. Women of increasing age, especially at the early to late reproductive age, are particularly vulnerable to PCOS. Herbal remedies remained in demand for several reasons, including high cost and side effects associated with the use of allopathic drugs and our traditional practices, which have aided humans to use more herbal products for their health benefits. Herbal medicines have been found to be cost-effective, safe, and a highly sought-after source of PCOS management/treatment than allopathic drugs. The purpose of finding out the role of herbal remedies in PCOS management was to find out about herbal remedies in PCOS management; diagnosis, signs, and symptoms of PCOS; causes of hormonal imbalance; and risk factors associated with PCOS and their management are briefly discussed in this literature review.
Source link: https://doi.org/10.3389/fphar.2022.874914
Polycystic ovary syndrome is the most common hormonal disorder among women of reproductive age, and it is the primary cause of fertility problems in women. Today, instead of chemical drugs, using medicinal plants instead of chemical drugs may be a better treatment option for PCOS. The aim of this research was to determine the effects of Calendula officinalis hydroalcoholic extract on PCOS in rats. Six groups were randomly divided into six groups, including control, sham, PCOS group, and treated PCOS groups receiving Calendula officinalis hydroalcoholic extract in different doses of 200, 500, and 1000 mg/kg. PCOS was caused by subcutaneous injection of DHEA 6 mg/100 g bw for 35 days. In the treated groups with high doses of Calendula officinalis extract, a trend of improvement was observed. Calendula officinalis hydroalcoholic extract produced elevated ovulation, improved oxidative stress, restored folliculogenesis, and increased ovulation in rats with PCOS and nonovulation.
Source link: https://doi.org/10.1155/2022/7402598
IGT was highly evident in the u226595th percentile BMI group, compared to the 92nd percentile BMI group. Patients with obesity had a significant rise homeostasis model assessment and a lower whole body insulin sensitivity index in comparison to patients without obesity. When controlling for body mass index, free testosterone levels were also higher in patients with obesity and were also significantly associated with HOMA-IR. IGT was found to be significantly elevated in patients with obesity in adolescents with PCOS, as a result of abnormal glucose metabolism in over one-fifth of the patients. HbA1c alone may be a poor way to determine IGT, and we recommend that adolescents with PCOS and obesity perform formal oral glucose tolerance testing.
Source link: https://doi.org/10.1186/s12902-022-01098-0
Objective Polycystic ovary Syndrome is a common endocrine disorder with high incidence in the United States. Objective Polycystic ovary syndrome is a common endocrine disorder with high risk. Bioinformatics analysis is used to identify shared gene signatures and biological interactions between PCOS and EC. Methods Bioinformatics analysis based on GEO database consisted of data integration, network design, and functional enrichment analysis. Results ten hub common genes, MRPL16, MRPS11, RPL26L1, ESR1, JUN, UBE2I, RPL17, GTF2H3, and PCOS were identified as shared gene signatures for EC and PCOS. These hub genes were found to be closely related by GO and KEGG pathway analysis, U201d, u201cstructural component of ribosomes, u201d, u201d A good binding relationship of fenofibrate with established targets was established by Molecular docking analysis, demonstrating a strong correlation between the two species. In addition, the cellular structures of these signatures were investigated, and potential drug molecules associated with PCOS and EC were tested out.
Polycystic ovarian syndrome is a common endocrine disorder affecting women, with a close correlation to metabolic syndrome and obesity. We want to establish the circulating levels of CTRP15 and assess its correlation with cardiometabolic and inflammatory parameters in PCOS women in the current study. 120 PCOS patients and 60 healthy non-PCOS controls were included in this case-control investigation. The ELISA method was used to determine serum adiponectin and CTRP15 serum levels in hs-CRP by commercial kits, while serum adiponectin and CTRP15 were determined by serum samples. In PCOS-RPL and PCOS-inf subgroups, the rates of CTRP15 were significant higher than those in controls. Also, serum adiponectin was much lower in the PCOS group and subgroups, while serum hs-CRP, fasting insulin, HOMA-IR, and free testosterone were all elevated when compared to the non-PCOS group. The elevated CTRP15 levels may be a compensatory mechanism for the syndrome's metabolic dysregulations.
Source link: https://doi.org/10.1371/journal.pone.0263658
Background Polycystic ovary syndrome is common in puberty, and the cause is uncertain. This research sought to investigate the pathogenesis of pubertal polycystic ovary syndrome and assess the therapeutic effects of electroacupuncture on pubertal PCOS. Randomly divided into a model group, an electroacupuncture group, and a sham acupuncture group, according to a sham acupuncture group. In pubertal rats with PCOS, EA significantly reduced estrous cycle disorders and the ovarian polycystic morphology, but SA only increased estrous cycle disorders, but not necessarily improved estrous cycle disorders. The serum levels of insulin, neuropeptide Y, and fasting blood glucose increased significantly in the model group, while the serum levels of ghrelin decreased significantly. The NPY and FBG went into decline after treatment with EA, while insulin levels increased. Between the four groups there were no differences in the hypothalamic expression of galanin, galanin-like peptide, and the ghrelin receptor. EA can help recover NPY and neuropeptide mRNA, downregulation of GHRL protein and mRNA in the hypothalamus, as well as decreased expression of GHRL in the arcuate nucleus. SA's findings of FBG and insulin levels, as well as the protein expression of ghrelin in the hypothalamus and ARC, don't appear to make no difference to FBG and insulin levels. Neither EA nor SA will be able to attenuate the upregulated kisspeptin protein expression in PCOS model rats' pancreas.
Source link: https://doi.org/10.1371/journal.pone.0259609
CIBERSORT was used to investigate differential immune infiltration, and the correlations of biomarkers with infiltrating immune cells were investigated. In PCOS, the gene sets relating to immune response and adaptive immune response were differentially stimulated. We found two diagnostic biomarkers of PCOS in our database, one on the HD domain containing 3 and syndecan 2. The validation of hub biomarkers in clinical samples using RT-qPCR was consistent with bioinformatics findings. According to an immunological infiltration report, activated mast cells and increased eosinophils may have been a factor in PCOS' pathogenesis. HDDC3 was positively related to T regulatory cells, stimulated mast cells, and monocytes, but it was not positively linked to activated memory CD4 T cells in PCOS, but not in PCOS. Result: HDDC3 and SDC2 can act as candidate biomarkers of PCOS and provide new insight into PCOS' molecular mechanisms of immune control.
Source link: https://doi.org/10.1186/s13048-022-01013-0
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