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Polycystic Ovary Syndrome - Crossref

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Last Updated: 20 July 2022

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Potential role of d - chiro -inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome

Before and after DCI therapy, we investigated oxidative-related changes in inositol in the blood of women with PCOS. A total of 38 healthy-weight PCOS women were investigated before and after the DCI period by testing serum testosterone, serum androstenedione, fasting serum glucose, and measurement of IR. In conclusion, PCOS patients suffer from a systemic oxidative stress that promotes endothelial dysfunction. Improved IR can reduce hormonal, metabolic, and oxidative abnormalities in PCOS patients, reducing hormonal, metabolic, and oxidative abnormalities.

Source link: https://doi.org/10.1139/cjpp-2021-0766


Present and Future: Crosstalks Between Polycystic Ovary Syndrome and Gut Metabolites Relating to Gut Microbiota

Polycystic ovary syndrome is a common disorder that affects 88%–u201313% of females of reproductive age, jeopardizing their fertility and long-term health. However, the PCOS's source is also unknown. The recent study of gut microbiota in metabolism has been largely focusing. Although the abnormalities in gut microbiota and metabolites may not be the primary causes of PCOS, they may play a significant role in PCOS' pathological process. PCOS progression can be influenced by gut microbiota dysbiosis and disturbance of gut metabolites. However, the role of gut microbiota in PCOS has yet to be fully investigated yet. This paper seeks to discuss the potential effects and modulative functions of the gut metabolites on PCOS and potential intervention targets, thereby providing more potential treatment options for PCOS in the future.

Source link: https://doi.org/10.3389/fendo.2022.933110


An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS) like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry

Prior studies have shown that murine ovarian explants and isolated ovarian follicles can retulate human-like 28-day cycles in vitro with predictable patterns of estradiol and progesterone secretion in response to gonadotropin stimulation. Seven steroid hormones were found in culture media, according to a secondary aim of the investigation, which was to create a high-throughput, responsive, and specific liquid chromatography assay to measure seven steroid hormones in conditioned culture media. Ovaries were obtained from 12-day-old CD-1 mice and cultured for 28 days, with ovulation induction on culture day 14.

Source link: https://doi.org/10.3390/biomedicines10071646


SERUM SCLEROSTIN AND DICKKOPF-1 LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Multiple research has been published on the effects of PCOS on bone metabolism, but there is currently no reliable data on the risk of osteoporosis in PCOS. METHODS: This review was done retrospectively to determine Scl and DKK1 prevalences in women with PCOS. The PCOS and healthy participants' waist-to-hip ratios were higher than the control group, but there were no significant differences between women with PCOS and healthy individuals in terms of Scl and DKK1 ratings, according to this report. Although amenorrhea causes bone loss in PCOS patients, the positive effects of hyperandrogenemia and hyperestrogenemia on bone density can be seen as a balancing function.

Source link: https://doi.org/10.18229/kocatepetip.833378


Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

Polycystic ovary syndrome is a common, intricate, and heterogeneous endocrine disorder of women that responds to a combination of environmental and genetic causes. PCOS impacts women of increasing age, particularly at the early to late reproductive age. Currently, PCOS affects 1 in every ten women globally. Herbal medications remained in demand for several reasons, including high price and side effects associated with the use of allopathic medicine and our modern standards, which have encouraged humans to use more herbal products for their health care. Herbal medicines have been found to be cost-effective, efficient, and a highly revered source of PCOS management/treatment over allopathic drugs. In this literature review, diagnosis, signs, and symptoms of PCOS; causes of hormonal imbalance; and risk factors relating to PCOS and their administration are briefly discussed; and finally, finding out the role of herbal remedies in PCOS management was explored briefly.

Source link: https://doi.org/10.3389/fphar.2022.874914


Anxiety and Depression in Women with Polycystic Ovary Syndrome

Background and Objectives: Mental health disorders are often the result of hormonal disorders like those accompanying polycystic ovary syndrome, where changes in appearance and having to deal with a variety of other health problems are common due to this condition. The aim of this research was to determine the prevalence and severity of anxiety and depression, as well as the ways that women with PCOS cope with stress compared to healthier women in order to determine the relationship of socioeconomic variables in relation to levels of anxiety and depression with ego-resiliency and stress-coping strategies. In comparison to healthy women, the women with PCOS had higher rates of anxiety and depression, as well as lower ego resiliency. The women with PCOS used passive stress-coping techniques more often than those with healthy women. Women with PCOS should be tested for anxiety and depression, according to their reports.

Source link: https://doi.org/10.3390/medicina58070942


TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

TLR4 and NF-u03baB serum, body temperature, inguinal fats weight, inguinal fats, fasting glucose level, ovarian morphology, NF-u03baB signaling target genes in ovary, NF-u03baB signaling target genes in ovary, NF-u03baB signaling target genes in ovarian morphology, NF-u03baB serum genes in heaB In LET-induced PCOS rats, the protein expression of TLR4 and NF-u03baB in cytoplasm of ovarian and inguinal fats was elevated in cytoplasm of ovarian and inguinal fats, rather than control groups, although NF-u03baB in nucleus was reduced in PCOS rats. ACTB, C3, CXCL3, NQO1, and SELP in ovarian PCOS rats treated by LET were statistically different in comparison to control groups. Conclusion These findings showed that stimulating TLR4/NF-u03baB pathway in inguinal fats and ovary tissues contributed to the elevated inflammation in LET-induced PCOS rats, which in turn exacerbated the phenotype of PCOS, including weight gain, adipose tissue accumulation, hyperglycemia, and follicular dysplasia.

Source link: https://doi.org/10.1101/2022.07.14.500077


Dysglycemia screening with oral glucose tolerance test in adolescents with polycystic ovary syndrome and relationship with obesity

Abstract Background: Adolescents with polycystic ovary syndrome are at a higher risk of impaired glucose tolerance and type 2 diabetes mellitus in comparison to type 2 diabetes mellitus. IGT was highly evident in the u226595th percentile BMI group, relative to the 96th percentile BMI group, with 106 adolescents with PCOS who had OGTT results available. Patients with obesity had significant elevated homeostasis model evaluation and lower whole body insulin sensitivity index when compared to those without obesity. When controlling for body mass index, free testosterone levels were still higher in patients with obesity and were also highly associated with HOMA-IR. IGT was found to be noticeably higher in patients with obesity during a clinical investigation, with abnormal glucose metabolism affecting over a quarter of the patients.

Source link: https://doi.org/10.1186/s12902-022-01098-0


Effect of Administrating Coenzyme Q10 with Clomiphene Citrate on Ovulation Induction in Polycystic Ovary Syndrome Cases with Resistance to Clomiphene Citrate: A Randomized Controlled Trial

Objectives: The aim of this research was to determine the effect of mixing low doses of Coenzyme Q10 with clomiphene citrate on ovulation induction in polycystic ovary syndrome women with clomiphene resistance. Methods: A total of 149 women with clomiphene-resistant PCOS who needed ovulation induction were randomly selected into the oral clomiphene citrate and Coenzyme Q10 group and the oral clomiphene citrate only group with a computer generated allocation sequence. The proportion of women who ovulated with combination was higher among the 133 women tested, and the mixed group had a higher fertility rate per cycle than those who received only clomiphene was greater. Women who received a combination were six times more likely to conceive than women who only had clomiphene citrate. Conclusion: Coenzyme Q10 is a valuable adjunct in women with PCOS who are experiencing ovulation induction.

Source link: https://doi.org/10.18502/jri.v23i3.10008


Nesfatin-1, Dopamine, and NADPH levels in Infertile Women with Polycystic Ovary Syndrome: Is There a Relationship Between Their Levels and Metabolic and Hormonal Variables

Background: Polycystic ovary Syndrome is the most common endocrine disease affecting women of reproductive age. Methods: 60 PCOS patients and 24 controls were included in this observational study, as well as 24 controls. Results: In this study, there were markedly elevated waist hip ratio and body mass index in PCOS patients compared to controls. In PCOS patients, there was a significant rise in FSH, LH, prolactin, estradiol, testosterone, Nesfatin-1, and dopamine, as well as a decline in NADPH. Also, significant positive correlations were found between dopamine and BMI, FSI, FSH, LH, estradiol, and prolactin levels, as shown by NADPH and BMI, FSI, FSH, LH, estradiol, and prolactin levels; however, significant negative correlations were found between NADPH and BMI, FSI, estradiol, and prolactin levels; however, there were no relationship between dopamine, compared to BMI, compared to dopamine and BMI, FSH, LH, compliant, lactin levels, LSI, FSI, LH, prolactin levels; however, lew, emisi, dependant correlationsi, creatin lactin, FSI, estradiolactin levels, prolactin FSI, leut, def, prolactin, and BMI, FSI, Conclusion: Elevated serum Nesfatin-1 concentrations and their association with hyperprolactinemia suggest that they play a role in PCOS pathophysiology. In addition, elevated dopamine and reduced NADPH levels may have a role in PCOS pathogenesis.

Source link: https://doi.org/10.18502/jri.v23i3.10006

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions