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In their cross-sectional study, insulin sensitivity was linked to the periodontal disease, but they were unable to draw definitive conclusions about the role of reduced insulin sensitivity in periodontal infection pathogenesis. In addition, periodontal intervention may raise glycemic control, insulin resistance, and serum inflammatory cytokine levels in type II Diabetes patients with chronic periodontitis. Both PCOS and periodontitis have been attributed to elevated CRP levels, and it has been speculated that CRP may be a potential mediator of the relationship between periodontitis and PCOS. Both PCOS and periodontitis have been attributed to elevated CRP levels, so it is speculated that CRP may be a potential mediator of the connection between periodontitis and PCOS. As, periodontitis and insulin resistance are both related to systemic inflammation and insulin resistance In terms of elevated inflammatory markers, previously published cross-sectional studies showed a potential association between PCOS and periodontitis and the effect of PCOS on gingival inflammation and gingival inflammation. However, they have yet to investigate the effect of periodontal therapy on systemic inflammation and insulin resistance in PCOS women with periodontitis. Therefore, the investigation was designed to investigate the effect of non-surgical periodontal therapy alongside medical intervention on hsCRP, Homeostatic Model Assessment, and periodontal parameters in PCOS women with periodontitis. AIM - An analysis of the effects of polycystic ovary syndrome on periodontal status of women of both adolescent and adult age groups. PROBING POCKET DEPTH: POCKET DEPTH : The distance from the gingival margin to the clinical pocket will be determined. CEJ's Distance from the base of the pocket from the gingival margin, as well as the distance from a free gingival margin. Gingivitis - According to AAP's 2017 classification 8. SURVEILLANCE OF PERIODONTITIS Radiographs is used to analyze staging and grading of periodontitis. Thin scalloped biotype in which there is a greater correlation with slender triangular crown, subtle cervical convexity, interproximal contacts close to the incisal edge and a narrow region of KT, smooth thin delicate gingiva, and a thin alveolar bone are present. According to the American Academy of Periodontology and European Federation of Periodontology, 2017 classification, Cairo, 2011. According to the American Academy of Periodontology and European Federation of Periodontology, the apical shift of the gingival margin with respect to the cemento-enamel junction has been classified as the apical shift of the gingival margin with respect to the cemento-enamel junction; it is associated with attachment loss and exposure of the root surface to the oral environment. Anthropometric Parameters,Waist circumference will be measured in centimeters at the midpoint between the lower margin of the lowest palpable rib and the top of the iliac crest at the midpoint. After overnight fasting, lood Sampling-blood samples for the investigation of serum hsCRP will be collected after midnight fasting. After applying a tourniquet in plain tubes without additive, a sample of Venous blood from the antecubital vein will be collected. Assay, in which human CRP agglutinates with latex particles coated with monoclonal anti-CRP antibodies, the test procedure will be performed with particle-enhanced immune-turbidimetric assay. The turbidity caused by the formation of immune complexes will be measured at 546 nm. Testosterone levels 13. 33 Serum Testosterone levels 13. PCOS-according to Rotterdam's guidelines and AE-PCOS Society requirements, according to the AE-PCOS Society's phaenotype.
Source link: https://clinicaltrials.gov/ct2/show/NCT05113030
Patients with insulin resistance in Polycystic Ovary Syndrome patients with insulin resistance vs. metformin's clinical trial seeks to determine the safety and effectiveness of canagliflozin vs. metformin. Women aged 18-45 years with IR were enrolled and randomly assigned to either canagliflozin 100 mg or metformin 1500-2000 mg daily for 12 weeks.
Source link: https://clinicaltrials.gov/ct2/show/NCT04700839
The investigation will enroll both Vietnamese infertile women with PCOS, according to the Rotterdam principles at IVFMD Tan Binh and IVFMD Phu Nhuan. Based on standard study protocols, such as hyperandrogegism, sexual dysfunction, and polycystic ovarian morphology, the participants in this study will be divided into A, B, C, and D, according to expert and experience physicians, according to BMI's weight, height, waist, and hip circumference, waist to hip ratio, and hip to hip ratio, followed by World Health Organization recommendations for Asian women. Blood pressure Fat mass measurement by specific calipers that are not readily available at the clinic. Diagnosis of diabetes mellitus can be obtained with fasting glucose u2265126 mg/dL or HbA1C u22656. 5 percent. The Oral glucose tolerance test with 75 g glucose will be administered to those with normal fasting glucose and HbA1C levels. Women will be able to have a normal diet for three days and overnight fasting for at least 8 hours, according to the woman. The blood draw will be performed twice: fasting and 2 hours after solution administration. When two-hour glucose levels rise to 199 mg/dL, impaired glucose tolerance will be diagnosed. Hyperandrogenism: Clinical hyperandrogenism: Hirsutism: a case of acute acne and severe acnes, Ferriman Gallwey's score and severe acne are among the causes of severe acnes. Biochemical hyperandrogenism: free testosterone, free testosterone indice, SHBG.
Source link: https://clinicaltrials.gov/ct2/show/NCT04364087
If the patient meets Rotterdam requirements and their serum vitamin D level is between 6 and 29 ng/mL, the patient and their guardian will be invited for inclusion in the research by either dedicated research nurses or certified research nurses. Using the Beck Depression Inventory-II, the gold standard self-report depression questionnaire, will be evaluated at time of randomization, 3 months post randomization, and 6 months post randomization. All adolescents seen at Yale New Haven Children Hospital outpatient clinics with a screening system for patients with clinically high rates of depression are now administered with a depression screening tool. Patients will be unblinded, and patients with vitamin D levels below threshold will be treated with vitamin D therapy after post-trial analysis. Hypothesis: Vitamin D supplementation in adolescents with PCOS and/or at risk for PCOS and/or low amounts of vitamin D will lower serum androgen and anti-mullerian hormone levels. Aim 2: To investigate the effect of vitamin D replacement on clinical characteristics of PCOS in adolescent female patients. Hypothesis: Vitamin D supplementation in adolescents with PCOS, acne, and hirsutism are all associated with low blood supply. Aim3: To investigate the effects of vitamin D replacement on depressive symptoms in adolescent female patients with PCOS. Hypothesis: Vitamin D supplementation in adolescents with PCOS or at risk of PCOS will cause anxiety, as well as low serum vitamin D deficiencies could exacerbate symptoms of depression.
Source link: https://clinicaltrials.gov/ct2/show/NCT04355572
Background: Polycystic ovarian syndrome is the most common reproductive endocrinopathy in women of reproductive age with numerous associated metabolic disorders, including hyperinsulinemia, insulin resistance, and a high lifetime risk of type 2 diabetes mellitus. In several endocrinopathies, the effects of time-restricted eating on metabolic profiles have been investigated, but there are no studies in PCOS. Methods: This research will explore the possibility of time-restricted eating in PCOS management, as well as the effects on insulin levels and other metabolic characteristics. The investigators will enroll 20 patients with PCOS in order to do this. Participants select their own 6-hour period based on their lifestyle and preference. Usual eating habits, no time limit, no other dietary advice If fasting, participants are allowed to drink plain water, unflavoured/unsweetened sparkling water, black breakfast tea, and black coffee. Dietary intakes will be determined at baseline, at the midpoint of each research arm's study, and at the end of the trial using Nutritics software. Participants can log their food intake using the Nutritics 'app'. The Paid t-test will be used to determine between baseline and post intervention results. Based on research in other populations, time-restricted feeding may have the ability to aid in the rise of insulin resistance in patients with PCOS. Based on the findings, the investigators will explore the consequences of time-restricted eating on insulin levels in the target group of women with PCOS.
Source link: https://clinicaltrials.gov/ct2/show/NCT05126199
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