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Point Mutation - Springer Nature

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Last Updated: 24 June 2022

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Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

In this study, we use SomaGene, a newly developed tool, to look at de novo somatic point mutations from the International Cancer Genome Consortium's whole-genome sequencing results of 1,855 breast cancer samples. We find ten30 candidates of ncRNAs that are significantly and specifically mutated in breast cancer samples. SNPs from other cancers are not used in such enrichment. We then show that 82% of our candidate ncRNAs significantly interact with the promoter of protein-coding genes, as well as previously reported cancer-associated genes, underscoring the crucial role of candidate ncRNA genes in the transcription of key regulators of growth and differentiation in breast cancer. Our list of breast cancer-specific ncRNA genes has the ability to provide a greater insight into breast cancer's root genetic causes.

Source link: https://doi.org/10.1038/s42003-022-03528-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions