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Pleurisy - Europe PMC

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Last Updated: 11 April 2022

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Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.

The rise of reactive oxygen species, myeloperoxidase, and malondialdehyde, as well as a decrease in glutathione induced by CAR could be reversed by Leo's treatment. Leo reduced the amount of proinflammatory cytokines interleukin-1, tumor necrosis factor-, and mature macrophages and elevated the amounts of antiinflammatory cytokines in a clinically reduced the amounts of antiinflammatory cytokines. In addition, Western blotting revealed that Leo significantly triggered the Nrf2 pathway to restrain the thioredoxin-interacting protein/NOD-like receptor protein 3 and nuclear factor kappa-B pathways.

Source link: https://europepmc.org/article/MED/35285100


Epidemiologic evaluation of pleurisy diagnosed by surgical pleural biopsy using data from a nationwide administrative database.

Background Pleurisy is investigated by a variety of techniques, including needle biopsy, local anesthetic thoracoscopic examination, and surgery. To date, there have been no national epidemiological studies into pleurisy diagnosed by surgical pleural biopsy. In a Japanese national administrative database, this report examined the epidemiology of pleurisy detected by surgical pleural biopsy. Methods We analyzed the results of 24 173 patients who underwent video-assisted thoracoscopic surgery or open thoracotomy and developed a diagnosis of pleurisy between April 2014 and March 2020. Findings This review included data from 1699 patients. The most common causes of pleurisy were neoplastic diseases, infectious diseases, collagen vascular diseases, and paragonimiasis. Physicians may wish to perform surgical biopsy in light of the growing body of pleurisy when a definitive diagnosis cannot be made by needle pleural biopsy cannot be made.

Source link: https://europepmc.org/article/MED/35243795


Diagnostic role of internal mammary lymph node involvement in tuberculous pleurisy: a multicenter study.

A tool that can raise the likelihood of TP on a pre-test basis is likely to be useful in determining diagnostic procedures, and internal mammary lymph node expansion has been suggested to play a potential role. The aim of the present study was to determine IMLN involvement in TP in a multi-centric case-control study by comparing its prevalence and test results to those in patients with infectious, non-tuberculous pleurisy pleurisy, and controls free of respiratory diseases. Prevalence, reliability, accuracy, and prediction values of ipsilateral IMLN involvement between cases and control groups were investigated, as well as concordance between chest computed tomography and thoracic ultrasound results were explored. Results The prevalence of ipsilateral IMLN involvement in TP in TP was significantly higher than that found in NTIP and CP groups. The comparison of CT scan and ultrasound revealed moderate agreement.

Source link: https://europepmc.org/article/MED/35190300


Amentoflavone Ameliorates Carrageenan-Induced Pleurisy and Lung Injury by Inhibiting the NF-κB/STAT3 Pathways via Nrf2 Activation.

Many natural flavonoids, such as pleurisy, can trigger nuclear factor erythroid 2-related factor 2, which is crucial in preventing many disorders related to inflammation and oxidative stress. We wanted to see if AMF shields against pleurisy and lung injury caused by carrageenan's carrageenan by inactivating Nrf2. Our findings showed that AMF shielded against Car-induced pleurisy and lung injury. In addition, AMF reduced SOD and GSH depletion, as well as MDA and MPO production in mice's lung tissue. AMF stimulated Nrf2 by keap-1 dissociation and subsequent rise in heme oxygenase-1, NADH-quinone oxidoreductase 1, and -glutamylcysteine ligase values. AMF also reduced IL-1-TNF- and TNF--TNF- levels and elevated IL-10 levels in pleural exudate by blocking the inflammatory NF-B, signal transducer and activator of transcription 3 and extracellular signal-regulated kinase pathways triggered by Car. AMF had anti-inflammatory and antioxidative properties in Car-induced lung injury and pleurisy in a Nrf2-dependent manner, according to our study.

Source link: https://europepmc.org/article/MED/35237153

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions