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Pleurisy - DOAJ

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Last Updated: 25 January 2023

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Adenosine deaminase cutoff value when diagnosing tuberculous pleurisy in patients aged 40 years and older

Tuberculous pleurisy is one of the most typical signs of extra-u2010pulmonary tuberculosis. Physiology of Tuberculous pleurisy Tuberculous pleurisy is one of the most typical signs of extra-u2010pulmonary tuberculosis. A closed needle pleural biopsy is recommended for patients aged u226540 years, with an adenosine deaminase concentration of 40 percent in U/L. We want to find out whether the cutoff value of ADA and the cancer ratio in patients with TBP age u226540 years is wrong, as well as the effects of both compounded biomarkers on diagnosing TBP. ADA measurements were measured in pleural effusions from patients admitted to the Chest disease clinic between 2009 and 2016. In patients aged > 40 years old, a significant relationship was discovered between the serum LDH/pleural ADA ratio and ADA scores. Patients aged > 40 years and up to a 94. 2 percent sensitivity when using an ADA value of u226530 and a sLDH/pADA ratio of 16 yielded a sensitivity of 94. 2 percent in all patients and 69. 23% in patients aged > 40 years.

Source link: https://doi.org/10.1111/crj.13277


The Clinical Experience of Mycobacterial Culture Yield of Pleural Tissue by Pleuroscopic Pleural Biopsy among Tuberculous Pleurisy Patients

However, diagnosis of TB pleurisy is difficult due to the low success rate of pleural effusion mycobacterial culture and the difficulty in retrieving optimal pleural tissue. This research was designed to investigate the efficacy of mycobacterial cultures obtained from pleural tissue obtained by forceps biopsy by medical pleuroscopy in the diagnosis of TB pleurisy in TB pleurisy. Methods and Methods: This report retrospectively enrolled 68 TB pleurisy patients. Whether you're looking for a unique Mycobacterium tuberculosis bacteria in the pleuroscopic group: 37. 7%, 34. 8%, and 78. 3%, respectively. When pleural characteristic patterns revealed adhesion lesions and both adhesion lesions and the presence of micronodules, respectively, the sensitivity of M. TB culture from pleural tissue increased to 94. 4% and 91. 7%. Conclusions: When faced with unknown pleural effusion during pleuroscopic examination, M. TB cultures from pleural tissue should be considered a standard procedure.

Source link: https://doi.org/10.3390/medicina58091280


Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy.

We found that MTB-specific peptides of ESAT-6/CFP-10 can promote CD40L gene expression specifically in CD4 T cells, but not other cells from pleural fluid cells in patients with tuberculous pleurisy. CD4CD40L T cells were discovered to be mainly polyfunctional T cells that simultaneously produce IFN-u03b3, IL-2, and TNF-u03b1; and display an effector or effector memory phenotype. By flow cytometry, we established CD4CD40L and CD40L T cells to determine the specificity of CD4CD40L T cells. The expression of CD40L on MTB-specific T cells, as well as diagnosis of TB may be a useful indicator for the characterization and isolation of MTB-specific Th cells, according to our findings.

Source link: https://doi.org/10.1371/journal.pone.0020165


Evaluation of adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in patients with pulmonary tuberculosis and tuberculous pleurisy

Both direct microscopy and pleural fluid cultures are relatively low, with tuberculous pleural effusion typically containing a small number of mycobacteria. The u201cADA-test kit, which was developed in the Republican Scientific and Practical Center for Epidemiology & Microbiology, measured total ADA activity in pleural fluid and blood plasma. PTB patients with PTB had a mean plasma ADA level of 19. 2u00b13. 3U/L, which was significantly higher than the control group's control group. Patients with pleural TB and the controls are also significant. In patients with PTB and pleural TB, there was a significant rise in the activity of ADA1 and ADA2 in the blood plasma, according to the corresponding controls. In patients with TB pleural effusion, the ADA level in the pleural fluid was significantly higher. In cases of pleural TB, the mean ADA level in the pleural fluid was 74. 6 U/L, relative to 21. 9 U/L in non-tuberculosis effusion cases, according to the study. These results reveal that pleural fluid ADA1 and ADA2 levels were higher in patients with pleural TB than those with non-tuberculosis effusion. The sensitivity of the test for tuberculous pleurisy was 91% at the most precise cut-off level of 53. 4 U/L, according to an analysis of the ROC curve for pleural fluid ADA performance, and the specificity was 93%. Conclusion: This report found that pleural fluid ADA analysis could be a fast, inexpensive, highly specific and quick way to diagnose pleural TB.

Source link: https://doaj.org/article/6484b0dadceb4382a173752917806d8c


Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice

Abstract: Here we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. In an animal model of acute inflammation in vivo, we note here that green tea extract has potent anti-inflammatory properties. Our findings show that green tea extract supplementation provides a protective effect and provides a novel therapeutic strategy for lung injury prevention.

Source link: https://doi.org/10.1186/1465-9921-6-66


Head-to-head comparison of the efficacy of Xpert MTB/RIF Ultra and Xpert MTB/RIF for the diagnosis of tuberculous pleurisy

Using the meta-analysis method, the purpose of this research was to determine the diagnostic reliability of Xpert MTB/RIF Ultra and Xpert MTB/RIF for the diagnosis of tuberculous pleurisy head-to-head. Multiple databases for TBP diagnosis using Xpert Ultra and Xpert, 2021, were searched for studies that included eligible studies on May 12, 2021. Accuracy of Xpert Ultra and Xpert was compared to that of the composite reference standard and culture. According to 6 studies, 6 studies compared Xpert Ultra and Xpert with CRS, and 5 studies compared Xpert Ultra and Xpert with culture. Compared to CRS, sensitivity and specificity of Xpert Ultra were 52% and 98%, respectively to CRS, and 82% and 77% respectively, relative to culture. The Xpert Ultra's sensitivity was moderate but higher than that of the Xpert; however, its specificity was poorer. TBP's role in the early and rapid diagnosis of TBP was limited.

Source link: https://doi.org/10.1097/MD.0000000000029363


Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema

TNF-101, IL-2, IL-6, TNF-b1, PAI-1, and t-PA measurements in pleural fluids of 40 patients with tuberculous pleurisy and 38 patients with tuberculous empyema were determined in IL-1, u03b2, IL-2, IL-6, TNF-­u03b2, TNF-u03b2, TNF- The rates of PAI-1, IL-1, u03b2 were higher, and t-PA, IL-6, were lower in pleural effusions of the patients with tuberculous empyema and who must undergo surgery than those who could be treated with closed drainage and anti-TB chemotheraphy.

Source link: https://doi.org/10.1155/2016/3068103


Sequential release of TNFα and phospholipase A2 in a rat model of LPS-induced pleurisy

In the pleural washings obtained at different times following the introduction of Escherichia coli lipopolysaccharide pleurisy in rats, the amounts of extracellular phospholipase A2 and TNF, as well as cell accumulation were determined. In this model of inflammation, the enzyme seems not to be stimulated by TNFu03b1, which may be involved in the downregulation of sPLA2 in this model of inflammation.

Source link: https://doi.org/10.1080/09629359791703

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions