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Placebo - U.S. Department of Veterans Affairs

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Last Updated: 26 July 2022

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Rationale, design, and methods: A randomized placebo-controlled trial of an immunomodulatory probiotic intervention for Veterans with PTSD.

Veterans of the United States military veterans from recent conflicts are suffering from symptoms linked to posttraumatic stress disorder. Many veterans are resistant to traditional health and mental health services. Here we detail the rationale, layout, and methods of a randomized placebo-controlled trial of Lactobacillus rhamnosus GG for posttraumatic stress disorder.

Source link: https://doi.org/10.1016/j.conctc.2022.100960


Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial.

The efficacy of repeated intravenous ketamine doses was found to reduce signs of posttraumatic stress disorder. Infusions of intravenous placebo, low dose, or standard dose ketamine were divided between veterans and service members with PTSD who had failed previous antidepressant therapy. The primary outcome measure was the self-report PTSD Checklist for DSM-5, and secondary outcome measures were the Clinician-Administered PTSD Scale and the Montgomery u00c5sberg Depression Rating Scale. No significant group-by-time interactions for PTSD symptoms determined by the PCL-5 or CAPS-5 were present. The MADRS experienced depression that was more than placebo when compared to placebo. This clinical trial was unable to find a significant dose-related effect of ketamine on PTSD symptoms. Secondary research showed that the standard dose had rapid antidepressant effects. To determine the role of ketamine in PTSD treatment, further studies are required.

Source link: https://doi.org/10.1038/s41386-022-01266-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions