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CMC is prone to develop skin, nails, and the moist lining of body cavities caused by a fungus called Candida. CMC is typically the first of the three key APECED characteristics to become apparent in people with this disorder. Infections of the tube that moves food from the mouth to the stomach are also common, though the skin and nails are less affected. Parathyroid hormone production is reduced as a result of damage to the parathyroid glands. In a third key feature of APECED, adrenal gland insufficiency, damage to the small hormone-producing glands on the roof of each kidney's kidney results in a third major feature of APECED, adrenal gland insufficiency. People with APECED have a variety of additional signs and symptoms related to non-endocrine tissues. Teethy enamel on the teeth and chronic diarrhea or constipation may be among the early signs and symptoms that can be related to a lack of nutrients from food. APECED has five key characteristics that make people with the disease more noticeable than others: stomach pain, liver inflammation, cough, and dry eyes, kidney disease, and dry skin and dry eyes, hair loss, skin whitening, high blood pressure, and a small or absent spleen are all typical signs that can lead to permanent organ and tissue damage if left untreated.
Hypophosphatasia is an inherited condition that affects bone and teeth formation. Hypophosphatasia diminishes and softens the bones, causing skeletal abnormalities similar to another childhood bone disorder called rickets. Hypophosphatasia that appear in childhood or adulthood are usually less severe than those that appear in infancy. One of the first signs of the disease in children is early tooth loss. Adult hypophosphataemia is characterized by a softening of the bones known as osteomalacia. Chronic pain can be aggravated by repetitive fractures in the foot and thigh bones in adults. Adults with affected adult can lose their secondary teeth early and are at a greater risk of joint pain and inflammation. People with this disorder are typically affected by irregular tooth formation and tooth loss, but not have the skeletal abnormalities present in other forms of hypophosphatasia.
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