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However, in individuals with diabetic peripheral neuropathy, their expression and function in Schwann cells is uncertain. Here, we performed protein profiling and circRNA sequencing of sural nerves in diabetic peripheral neuropathy and controls patients. Protein profiling revealed 265 differentially expressed proteins in the diabetic peripheral neuropathy group. Further in vitro experiments showed that overexpression of circ_0002538 promoted Schwann cells' migration by upregulating plasmolipin expression. In addition, overexpression of circ_0002538 in the sciatic nerve in a streptozotocin-induced mouse model of diabetic peripheral neuropathy alleviated demyelination and increased sciatic nerve function. Cir_0002538 promotes PLLP expression by sponging miR-138-5p, according to a PLLP deficiency that further reduced Schwann cell migration. These results show that the circ_0002538/miR-138-5p/PLLP axis can promote Schwann cell transplantation in diabetic peripheral neuropathy patients, as well as improving myelin sheath structure and nerve function.
Source link: https://europepmc.org/article/MED/36571367
Diabetic peripheral neuropathy is a complex disorder exacerbated by long-standing diabetes. However, there is still no doubt about the beneficial effects of hydrogen in DPN. This paper was designed to determine the effects of exogenous hydrogen to reduce the severity of DPN in streptozotocin-induced diabetic rats. In the 4th and the 8th weeks, hydrogen inhalation significantly reduced blood glucose levels in diabetic rats relative to hydrogen-rich saline therapy. Hydrogen administration attenuated the decrease in the rate of motor nerve conduction in diabetic animals with a significant decrease. In the nerves of diabetic animals, hydrogen significantly reduced the expression of nuclear factor erythroid-2-related factor 2 and downstream proteins such as catalase and hemeoxygenase-1. Hydrogen has potent protective benefits in DPN by downregulating oxidative stress via the pathway of nuclear factor erythroid-2-related factor 2, which leads to its potential use in clinical settings, according to our paper.
Source link: https://europepmc.org/article/MED/36204786
For the first time, concurrent WMT in DPN determined the effectiveness of anodal tDCs over the left dorsolateral prefrontal cortex and cathodal right DLPFC. WMT's improved working memory and yielded lower anxiety levels than sham tDCS, but tDCS' efficacy was not superior to sham's in other cognitive domains, pain sensitivity, quality of life, and depression.
Source link: https://europepmc.org/article/MED/36630270
Background Extranodal NK/T-cell lymphoma, nasal type, is a rare, aggressive subtype of non-Hodgkin lymphoma, and it usually appears as a swollen sinus mass that can cause epistaxis. Presentation of the case A 17-year-old Chinese patient was seen with peripheral neuropathy and positive auto-antibodies. When the rash and peripheral neuropathy are the first signs and are accompanied by Epstein-Barr virus infection, we should be concerned about the development of ENKTCL-NT.
Source link: https://europepmc.org/article/MED/36627681
Background Oxaliplatin is one of the first-line drugs in solid tumor therapy. Aim The current research investigated pterostilbene-induced peripheral neuropathy in the hopes of determining the potential mechanisms involved in relieving oxaliplatin-induced peripheral neuropathy and investigating whether pterostilbene and celecoxib combination may provide greater relief. Colorimetric assay and total antioxidant capacity were evaluated by colorimetric assay, while apoptotic markers were determined by immunohistochemical analysis and qRT-PCR. pterostilbene and celecoxib abstled oxaliplatin-induced behavioral and motor impairments along with the restoration of histopathological changes, according to the study. In addition, p38 MAPK, JNK, ERK1/2, NF-u03b, COX-2, TNF-u03b1, and interleukins results have significantly reduced sciatic nerve. While reducing Bcl-2 level and TAC, Pterostilbene and celecoxib have reduced caspase-3 and Bax, MDA, while raising Bcl-2 level and TAC. Pterostilbene, inflammatory cytokines, oxidative, and apoptotic genes are among MAPKs cascades, inflammatory cytokines, oxidative, and apoptotic markers, among other things. In addition, co-administration of pterostilbene and celecoxib provides more relief from neuropathic pain.
Source link: https://europepmc.org/article/MED/36610639
Extranodal NK/T-cell lymphoma, nasal type, is a rare, aggressive subtype of non-Hodgkin lymphoma, and it usually appears as a brutal sinus mass that can cause epistaxis. A 17-year-old Chinese patient was shown with peripheral neuropathy and positive auto-antibodies in his case presentation. Pathological analysis established the diagnosis of CD30-positive primary cutaneous ENKTCL-NT in a pathological biopsy.
Source link: https://europepmc.org/article/MED/PMC9830812
Background and purpose The electrophysiologic characteristics of peripheral neuropathy secondary to nitrous oxide use are uncertain. The paper sought to summarize the electrophysiologic characteristics of N2 O-associated peripheral neuropathy as well as the risk factors for severe nerve injury. Methods The electrophysiologic and clinical findings of patients with peripheral neuropathy secondary to N2 O abuse at our hospital between 2018 and 2020 were analyzed retrospectively, and electrophysiologic changes were summarized. Results Most patients exhibited reduced sensory and motor nerve conduction velocities, reduced sensory nerve and compound motor action potentials, and increased distal motor latency, though a response was absent in 36 percent. These results show that N2 O abuse can result in generalized pain to sensory and motor nerve nerves. Peripheral nerve injury in the lower limbs was more prevalent in the lower limbs than in the upper limbs.
Source link: https://europepmc.org/article/MED/36606645
Objectives In this research, we wanted to investigate brain regions involved in sensory processing in diabetes in both painful and painful diabetic peripheral neuropathy as well as painless diabetic peripheral neuropathy and pain intensity. 19 people with type 1 diabetes and painful DPN, 19 with type 1 diabetes and painless DPN, 18 with type 1 diabetes and painless DPN, 18 with type 1 diabetes and painless DPN, 18 with type 1 diabetes and painless DPN, 18 with type 1 diabetes with no DPN, and 20 healthy control subjects were all assessed through this cross-sectional study. Conclusions Overall, compared with those with painful DPN and healthy control subjects, people with type 1 diabetes without DPN, and subjects with type 1 diabetes without DPN showed hyperconnectivity between thalamus and motor areas, as well as between postcentral gyrus and motor regions. It was also possible to group the phenotypes of type 1 diabetes with painful/painless DPN and type 1 diabetes without DPN, based on thalamic connectivity.
Source link: https://europepmc.org/article/MED/36469731
Polyangiitis granulomatosis with polyangiitis is a form of anti-neutrophil cytoplasmic antibody-associated vasculitis characterized by small- to medium-sized vessel vasculitis, which is often associated with eosinophilic granulomatous inflammation. Physicians should consider the possibility of EGPA as a differential diagnosis in cases of unexpected onset of leg ischaemia and peripheral neuropathy. In addition, the early administration of mepolizumab may have yielded better results in terms of limb ischaemia and peripheral neuropathy.
Source link: https://europepmc.org/article/MED/36107735
Peripheral neuropathy is a common symptom in patients with Parkinson's disease. We wanted to determine the prevalence and type of peripheral neuropathy in Parkinson's disease patients and then measure the functional effects on gait and balance. A cross-sectional study was conducted on a cohort of consecutive Parkinson's disease patients compared to movement disorders experts based on the UK Brain Bank's criteria to characterize the peripheral neuropathy type and aetiology. A total of 99 Parkinson's disease patients with a mean age of 67. 2 years and mean disease duration of 6. 5 years were evaluated. In the OFF medication state, significant differences were found between Parkinson's disease patients with and without peripheral neuropathy in the OFF medication state during stance with closed eyes on a foam surface, which was disappointing in the OFF medication state.
Source link: https://europepmc.org/article/MED/35088837
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