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Peripheral Neuropathy - DOAJ

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Last Updated: 15 July 2022

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Impact of Chemotherapy-Induced Peripheral Neuropathy on the Quality of Life in Cancer Patients

The aim of the investigation was to determine whether there were differences in peripheral neuropathy symptoms and their effect on the quality of life based on the type of agents used. Oxaliplatin had a significantly larger effect on the onset of motor and sensory neuropathy than taxane and cisplatin/carboplatin.

Source link: https://doaj.org/article/e5c8b3207dc64ede90da9bd36a486725


Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial

Abstract Background: The use of oxaliplatin in digestive tract cancers can cause severe peripheral neuropathy in patients and survivors, as well as decreasing the quality of life of patients and survivors. It will be the first clinical trial to determine the efficacy and safety of donepezil for OIPN management. According to QLQ-CIPN20's sensory score, at least six months after the end of an oxaliplatin-based chemotherapy will be included, adult cancer survivors with OIPN who present sensory neuropathy. Patients in eighty will be randomly assigned to either donepezil or placebo over the course of 16 weeks of therapy. For a response rate of at least 30% in the donepezil arm, this type I error rate yields a rate of 0. 0417 and 91%. Discussion This study will help, in the case of encouraging findings, to launch a phase 3 randomised and placebo-controlled clinical trial to determine the therapeutic interest of donepezil in treating OIPN.

Source link: https://doi.org/10.1186/s12885-022-09806-8


Cellular Pathogenesis of Chemotherapy-Induced Peripheral Neuropathy: Insights From Drosophila and Human-Engineered Skin Models

Chemotherapy-induced peripheral neuropathy is a common and complicated condition resulting from chemotherapy therapy therapy. Starting from the hands and feet, the CIPN accompanies pain-related sensory functions. Our understanding of CIPN pathological mechanisms has been greatly enhanced by research focusing on neurons in vitro and in vivo models. However, considering the direct poison shown in both neurons and non-neuronal cells, in vivo or in vitro models that enable the investigation of neurons in their local environment are required. This review seeks to introduce concepts and findings from CIPN's in vivo models using small model organisms first. In vivo, we'll be focusing on Drosophila melanogaster CIPN models that are genetically amenable and available to investigate neuronal responses with the local environment. We will focus on in vitro techniques that can enable the investigation of pathological changes in neurons and the skin environment.

Source link: https://doi.org/10.3389/fpain.2022.912977


A cross-sectional study describing peripheral neuropathy in patients with symptoms of gastroparesis: associations with etiology, gastrointestinal symptoms, and gastric emptying

Using the Neuropathy Total Symptom Score-6, 250 patients with signs of gastroparesis underwent gastric emptying scintigraphy and answered questionnaires regarding the severity of gastroparesis symptoms, including gastroparesis severity using the Gastroparesis Cardinal Symptom Index and presence of peripheral neuropathy.

Source link: https://doi.org/10.1186/s12876-022-02372-0


Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice

Thermal hypothermia was observed in a murine model of DPN or TRPA1 mice caused by STZ in the present study, although temperature avoidance was not found in TRPV1 or TRPA1 in DPN mice caused by STZ, which specifically detects temperature avoidance. Temperature preference can be determined with a Thermal Gradient Ring in which mice can move freely in a temperature gradient, and we've already identified the temperature-dependent phenotype between DPN and TRPV1 mice.

Source link: https://doi.org/10.1038/s41598-022-14186-x


Postural Control in Diabetic Peripheral Neuropathy: A Narrative Review

Diabetes mellitus is a metabolic disease of chronic hyperglycaemia that can cause neurological disorders such as Diabetic Peripheral Neuropathy. When compared to healthy people, those with DPN are more likely to fall, especially in the geriatric population. The present study aims to provide an insight into the pathophysiology, outcome indicators, and physiotherapy therapy of chronic postural control in DPN. According to all reports, there is postural tension in people with DPN, which rises with age and duration of diabetes. In most of the studies with medio-lateral instability present in more cases, multidirectional postural sway was evident. Literature shows that multidirectional postural instability is present in DPN patients. People with DPN can be helped by physiotherapy, offloading systems, and diabetic foot care education to improve postural stability in individuals with DPN.

Source link: https://doi.org/10.7860/JCDR/2022/52191.16273


Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions

Diabetic peripheral neuropathy affects more than half of type 2 diabetes mellitus patients, triggering the urgent need for innovative pharmacotherapies. Although there are many rat and mouse T2DM models available, the phenotyping of DPN has been difficult, with inconsistent results across labs. Here we examine DPN phenotyping in rat T2DM models against the U2018Neurodiab-u2019 guidelines to determine uptake of the recommendations and explore how DPN phenotypes differ between models and according to diabetes duration and sex.

Source link: https://doi.org/10.4093/dmj.2021.0347


SUDOSCAN in Combination with the Michigan Neuropathy Screening Instrument Is an Effective Tool for Screening Diabetic Peripheral Neuropathy

Background Screening for diabetic peripheral neuropathy is essential to avoid severe foot ulceration, but the detection rate of DPN is unsatisfactory. We tested whether SUDOSCAN and the Michigan Neuropathy Screening Kit may be a helpful tool for detecting DPN in people with type 2 diabetes mellitus in clinical practice. We compared the discrimination effectiveness of the following techniques, MNSI only vs. MNSI plus 10-g monofilament test to MNSI plus. The MNSI plus SUDOSCAN model revealed higher areas under the receiver operating characteristic curve than the MNSI only model, and the SUDOSCAN only model or MNSI plus 10-g monofilament test revealed comparable AUC with MNSI only model. Conclusion The screening scheme for DPN that includes both MNSI and SUDOSCAN can detect DPN with acceptable discrimination accuracy, and it may be useful in Korean patients with T2DM.

Source link: https://doi.org/10.4093/dmj.2021.0014


Can imaging be the new yardstick for diagnosing peripheral neuropathy?—a comparison between high resolution ultrasound and MR neurography with an approach to diagnosis

Abstract Purpose: Peripheral neuropathies are a group of disorders that affect the peripheral nervous system that have been traditionally diagnosed using electrodiagnostic methods. After receiving IRB approval, a hospital-based prospective analytical study was carried out in a resource-limited setting on 180 peripheral nerves in 131 patients with signs of peripheral mononeuropathy. Conclusions Overall, the diagnostic accuracy of the proton density fat-saturated MR sequence was the highest in the proton density fat-saturated MR sequence, followed by high-resolution ultrasound. The sensitivity was highest for proton density fat-saturated sequence, but the T1 MR sequence had the highest specificity. This comparative report shows the value of imaging in diagnosing peripheral nerve pathologies in this comparative review, with a MRI reading of 93. 9 percent, which may be used as an imaging gold standard.

Source link: https://doi.org/10.1186/s13244-019-0787-6

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions