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Peripheral Neuropathy - DOAJ

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Last Updated: 15 January 2023

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Serum Neurofilament Light Chain: A Potential Biomarker for Peripheral Neuropathy

Neurofilament light chain is a cytoskeleton protein that makes up the physical appearance of neuron axons and is released when a neuron is injured, allowing it to determine neuronal injury severity. All abnormalities resulting from axonal injury will rise blood NfL levels, allowing NfL testing to be used as a measurement device. NfL levels can also be a predictive indicator of treatment success and peripheral neuropathy progression.

Source link: https://doaj.org/article/4bdb1791a8b9448eaa30f4bc3e3c71e9


The circ_0002538/miR-138-5p/plasmolipin axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy

However, their presence and function in Schwann cells in diabetic peripheral neuropathy sufferers are uncertain. We performed protein profiling and circRNA sequencing of sural nerves in diabetic peripheral neuropathy and controls in patients with diabetic peripheral neuropathy and controls. The circRNA sequencing findings were confirmed by a real-time polymerase chain reaction assay, which yielded 11 differentially expressed circRNAs. In addition, the overexpression of circ_0002538 in the sciatic nerve in a streptozotocin-induced mouse model of diabetic peripheral neuropathy enhanced sciatic nerve function and reduced sciatic nerve function. Cir_0002538 enhances PLLP expression by sponging miR-138-5p, according to the study, while a lack of circ_0002538 resulted in a PLLP deficiency that also hindered Schwann cell migration. These results show that the circ_0002538/miR-138-5p/PLLP axis can promote Schwann cell transplantation in diabetic peripheral neuropathy patients, as well as improving myelin sheath structure and nerve function.

Source link: https://doi.org/10.4103/1673-5374.355979


Prevalence and correlates of vibration perception threshold based diabetic peripheral neuropathy in Gujarati urban population: A cross sectional study

Both quantitatively and qualitatively, the Vibration perception threshold is a useful measure of screen vibration-based neuropathy. In a diabetic sample population, we investigated the prevalence that correlates VPT. Methods: In 100 under medical care of urban type 2 diabetics, a cross-sectional study was carried out. Results: Mean age was 57, mean duration was 9. 42 years, 40% were healthy, 28 percent were hypoglycemic, 28 percent were symptomatic for neuropathy, 28 percent were hypoglycemic, 28 percent were asthmatic, and 28 percent were obese, with 28 percent having co-existing hypertension and positive family history. In 10%, 20%, 38%, respectively, and moderate, or severe grades of DPN were present in 38 percent of participants and mild, moderate, and severe grades of DPN. VPT was correlated with all three glycemic control outcomes, both quantitatively and qualitatively imposing significant odds risk, both quantitatively and qualitatively, putting a high odds risk. Conclusion: We found 38% prevalence of DPN in chronic type 2 diabetics from a city Gujarat, which is attributed to symptoms, length, family history, and all measures of glycemic triad.

Source link: https://doi.org/10.4103/jfmpc.jfmpc_540_22


Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda

According to disease duration and diabetic control, approximately half of diabetic patients are expected to experience DPN. This research, which recruited 319 identified DM patients in rural Uganda, was performed in an outpatient clinic and a diabetic clinic at Kampala International University-Teaching Hospital between December 2019 and March 2020. MethodsA cross-sectional study that sought to determine the incidence and grade of DPN in DM patients in rural Uganda. Conclusions: According to the study, 65. 8% of participants had mild DPN, 42. 4% had moderate DPN, and 12. 8% had severe DPN. Therefore, clinicians should consider neurological examination as a routine during diagnosis of all DM patients, especially in rural areas, where funds and services are often lacking, so that complications related to Diabetic mellitus can be avoided.

Source link: https://doi.org/10.3389/fcdhc.2022.1001872


Psychological distress and quality of life in breast cancer survivors with taxane-induced peripheral neuropathy: A scoping review

paraphrasedoutput:Methods is a website that collects information about psychological distress in breast cancer survivors with chemotherapy-induced peripheral neuropathy caused by taxane chemotherapy. The study sought to identify psychological distress and its impact on quality of life in breast cancer survivors with chemotherapy-induced peripheral neuropathy associated with taxane chemotherapy, as well as the effects of the condition on quality of life. The aim was to find literature about psychological distress in breast cancer survivors with chemotherapy-induced peripheral neuropathy in breast cancer survivors with chemotherapy-induced peripheral neuropathy physiotherapy-based chemotherapy-based research looked at based on condition.

Source link: https://doi.org/10.3389/fonc.2022.1005083


Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

BackgroundParaneoplastic peripheral neuropathy exacerbated by olfactory neuroblastoma has not been reported to date. Case's article About an adult who hospitalized regularly over the past nine months for persistent pain and numbness in the legs. Conclusion The patient's neurological signs were also improved after the primary tumor biopsy was removed, confirming the diagnosis. The patient's neurological symptoms were also relieved after removal of the primary tumor, confirming the diagnosis's accuracy.

Source link: https://doi.org/10.3389/fneur.2022.1002076


Post-Marketing Analysis of Peripheral Neuropathy Burden with New-Generation Proteasome Inhibitors Using the FDA Adverse Event Reporting System

Proeasome inhibitors are an integral part of several myeloma therapies. In the newer generation PIs Carfilzomib and Ixazomib, there is a paucity of evidence highlighting the danger of developing PN. This investigation examined reports of PN issued with all three PIs using the Food and Drug Administration Adverse Event Reporting System, which was based on this report. Compared to BTZ, CFZ, and IZB, reported PN has a lower rate of reported PN, with RORs of 0. 19 and 0. 48, respectively.

Source link: https://doi.org/10.4274/tjh.galenos.2021.2021.0052


Association of Non-Dipping Blood Pressure Patterns with Diabetic Peripheral Neuropathy: A Cross-Sectional Study among a Population with Diabetes in Greece

In 20% of diabetes cases, diabetic peripheral neuropathy is present in 20–u20135 percent of cases. In a Greek population with diabetes, the aim of this research was to determine the correlation between DPN and HTN in a Greek population with diabetes. To divide diabetic neuropathy patients into two groups, we examined 102 adults for diabetic neuropathy from November 2020 to December 2021 using the Toronto Clinical Neuropathy Scale System to classify them into two groups. Females, on comparison to males, had a 65% lower risk of developing moderate/severe DPN.

Source link: https://doi.org/10.3390/nu15010072


Serum sodium ions and chloride ions associated with taxane-induced peripheral neuropathy in Chinese patients with early-stage breast cancer: A nation-wide multicenter study

Background: Taxane-induced peripheral neuropathy is a debilitating adverse effect of cancer treatments with taxanes, and can have to be reduced or stopped chemotherapy, as well as impact clinical and survival outcomes. Methods: We recruited breast cancer patients at seven cancer centers in China. Participants aged 18 years or older with stage I to III breast cancer who were planning to do primary neoadjuvant and adjuvant chemotherapy with taxanes were eligible. For every patient, we found the highest TIPN toxicity score for analysis since the first cycle. Results: The research included 873 breast cancer patients who received paclitaxel, docetaxel, or nanoparticle albumin-bound paclitaxel. Conclusions: The findings indicate that breast cancer patients with a higher cumulative chemotherapy dose, lower pretreatment sodium ions, and higher pretreatment chloride ions receiving taxanes should be monitored more closely to minimize the formation of short- and long-term TIPN.

Source link: https://doi.org/10.1016/j.breast.2022.12.034


Peripheral Neuropathy and Foot Care Practices Among Patients with Diabetes Mellitus Attending a Tertiary Care Hospital: A Cross-sectional Study

Introduction: Peripheral neuropathy is the most common microvascular complication of diabetes mellitus. Foot care is a vital component of diabetes management. This report was designed to determine the prevalence of peripheral neuropathy and foot care among diabetic patients. Methods: At Kathmandu University Hospital, Dhulikhel, a descriptive cross-sectional research was conducted on 178 patients diagnosed with diabetes mellitus and attending out-patient and in-patient departments of Internal Medicine. To determine peripheral neuropathy incidence and to assess foot care services, the Michigan Neuropathy Screening Instrument and the Nottingham Assessment of Functional Foot Care were used. However, females were found less likely to engage in foot care than males in comparison.

Source link: https://doi.org/10.22502/jlmc.v10i2.473

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions