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In Congo, no significant pediatric coronavirus disease 2019 cases have been identified as at the start of the pandemic. Hemoglobin M1, hemoglobin A1, hemoglobin F, and hemoglobin S were positive for immunoglobulin A1, 2. 9%, 19. 9%, and 38. 4%, respectively, although serology tests for acute respiratory syndrome coronavirus 2 antibodies were positive for immunoglobulin A1, hemoglobin M, and 38. 4% were positive for hemoglobin F, and 38. 4% were negative for immunoglobulin G. Chest X-ray demonstrated retrocardiac pneumonia in the left lung, and Doppler ultrasound of the left lower limb revealed a new total thrombosis in the left lung, as well as a recent total femoropopliteal thrombosis. This is the first report of a case of suspected acute respiratory syndrome coronavirus 2 infection in Congo that causes venous thrombosis and acute pericarditis, according to the best of the authors' U2019 findings. Conclusion We hypothesized that this case of venous thrombosis and acute pericarditis in a Congolese child with heterozygous sickle cell disease was related to severe acute respiratory syndrome coronavirus 2 disease.
Source link: https://doi.org/10.1186/s13256-022-03459-8
This report details the phenotype of patients with IRP and monogenic autoinflammatory disorders, as well as determining whether autoinflammatory disease genes are related to IRP and monogenic autoinflammatory diseases. Methods and Findings We retrospectively reviewed the medical records of patients with IRP and monogenic autoinflammatory diseases at a national center between 2000 and 2021. We analyzed 4 genes by next-generation sequencing in 128 patients with IRP and compared the prevalence of rare deleterious variants to controls obtained from the Genome Aggregation Database in 128 patients with IRP. Correlation was found in this cohort of patients with IRP, and it was linked to persistent pain. In IRP, rare deleterious MEFV variants were more common than in ancestral MEFV variants, according to ancestry-matched controls. Pericarditis is a result of interleukin-triggered monogenic autoinflammatory diseases, and IRP is linked to variations in MEFV, a gene involved in interleukin-u20131u03b2 processing. We also found that corcorosteroid use in IRP is also associated with persistent noninflammatory pain.
Source link: https://doi.org/10.1161/JAHA.121.024931
In the population of vaccinated individuals aged 12 to 39 years in Italy, Severe Acute Respiratory Syndrome Coronavirus 2 mRNA vaccines, BNT162b2, mRNA-1273, and myocarditis/pericarditis were found to be linked to severe Acute Respiratory Syndrome Coronavirus 2 mRNA vaccines, BNT162b2, myocarditis/pericarditis. Methods and findings We conducted a self-controlled case series study using national statistics on COVID-19 vaccination related to emergency care/hospital discharge databases. The exposure risk period for the first and second doses was compared to the baseline period. BNT162b2 and mRNA-1273, with RIs of 6. 55 2. 73 to 17. 65 in a first dose of mRNA-1273, an elevated risk of myocarditis/pericarditis was present in the [0 to 7 days risk period. After the second dose of mRNA-1273 went from 8. 8 4. 9 to 12. 9. 50, the highest risk was seen in males at [0 to 7 days after the first and second dose of mRNA-1273 from 12. 28 4. 09 to 36. 53; the number of EC increased from 11. 89 3. 90 to 36. 53; males at 6. 91. 48 to 36. 53; males at [0 to 7. 91, 36. 53; males at [0 to 6. 89; Conclusions This population-based survey of over three millions of people in Italy found that mRNA vaccines were linked to myocarditis/pericarditis in the population younger than 40 years. According to our findings, a greater risk of myocarditis/pericarditis was associated with the second dose of BNT162b2 and both doses of mRNA-1273. These results should be considered in light of the fact that mRNA vaccine safety has been demonstrated in preventing severe COVID-19 disease and death in humans.
Source link: https://doi.org/10.1371/journal.pmed.1004056
Following mRNA COVID-19 vaccines, CDC adverse effects of the COVID-19 vaccine are extremely rare, myocarditis and pericarditis are the most common among them, and constrictive pericarditis has been limited to a few patients. We describe a case of a 72-year-old male patient with right-sided heart failure, which began after 8 days of receiving the third dose of inactivated virus COVID-19-19 vaccine and his diagnostic tests including transthoracic echocardiography, chest CT scan, and cardiac magnetic resonance were in favor of CP.
Source link: https://doi.org/10.1016/j.radcr.2022.07.021
Patient was found to have Type I Brugada phenocopy, which is a Brugada sign seen on EKG with a reversible cause. Both the pericardial effusion and Brugada signs were resolved by high-dose steroids, providing further evidence of Brugada phenocopy.
Source link: https://doi.org/10.13175/swjpccs033-22
Background: Mycobacterium indicus pranii immunotherapy, adjunctive corticosteroids, or MIP combined with corticosteroids was compared to standard tuberculosis therapy for tuberculous pericarditis in a 2x2 factorial trial. Although MIP and/or corticosteroids had no effect on all-cause mortality or pericarditis-related mortality, corticosteroids' prevalence was downgraded to 12 months, corticosteroids reduced the risk of concomitis pericarditis. Methods: Participants with definite or probable TBP were randomly selected to receive five injections of MIP or placebo at 2-week intervals, as well as six weeks of oral prednisolone or placebo. Results: Immunotherapy with MIP did not significantly alter Th1 CD4 and CD8 T cells' frequencies relative to placebo. Prednisolone did not significantly reduce pro-inflammatory T cell responses in this sub-study despite the positive effects of prednisolone on hospitalizations and constrictive pericarditis in the IMPI trial.
Source link: https://doi.org/10.1016/j.jvacx.2022.100177
AimsWe wanted to investigate and report cases of pericarditis and pericarditis confirmed by cardiovascular resonance imaging in patients with a strong temporal correlation to SARS-CoV-2 vaccination. CMR found the diagnosis by CMR using eight patients had pericarditis and two patients had pericarditis, and two patients had pericarditis. Two patients had an LVEF 50% on echocardiography, and four patients had left ventricular global longitudinal strain values of 18%. On CMR, the preserved left ventricular ejection fraction was retained, although one patient had reduced LVEF on CMR, and one patient had reduced LVEF on CMR. Conclusions: All patients with pericardiocarditis were showing signs of myocardial injury in the left ventricle's lateral segments, especially in young males.
Source link: https://doi.org/10.3389/fcvm.2022.964412
We discuss a case in which a 17-year-old patient referred to our outpatient Doppler Department due to medical evidence of liver cirrhosis. The patient presented with non-specifi c signs, such as fatigue, pain in the right subregional area, and peripheral oedema. We performed Doppler sonography of the portal vein, which revealed a normal diameter of the portal vein with anomalous, phasic, and strongly pulsatile waveforms. In addition, inferior vena cava was dilated and the respiratory cycle remained unchanged. Such a complicated diagnostics involved unusual use of portal vein waveform in creating the correct cardiologic diagnosis.
Source link: https://doi.org/10.15557/JoU.2015.0019
Background: Pericarditis is a rare disease that is often associated with chronic kidney disease, immunosuppression, or recent pericardial disease. Occasionally, a more prolonged, indolent, subacute clinical course may be required. Case study: We present a case of a 57-year-old male patient with a history of smoking and moderate alcohol use and who was diagnosed with progressive dyspnea and cough. Urgent pericardiocentesis treated with 1. 1 liters of purulent fluid that increased MRSA. MRSA was also isolated from the blood and pleural fluid, which caused MRSA to be isolated from the blood and pleural fluid. The patient underwent left thoracotomy, decortication, and apericardial window, as well as three weeks of intravenous vancomycin therapy, resulting in an excellent result. Conclusion: Bacterial pericarditis is unusually rare pericarditis that has been traditionally associated with chronic medical disorders and necessitating a long hospital stay. Bacterial pericarditis must be identified in a timely manner and addressed vigorously to avoid a devastating result.
Source link: https://doi.org/10.1016/j.idcr.2022.e01583
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