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One of a number of microsporidia species that cause disease in honey bees is V. ceranae, and widespread attempts to develop new treatment techniques for bees that are infected with these pathogens are ongoing. Paromomycin reduces the infection sensitivity of this parasite in whole organisms when testing compounds for potential exposure against V. ceranae. While paromomycin therapy may lead to widespread honeybee health problems in agricultural settings, it does not provide a good anti-microsporidia agent for use in the field.
Source link: https://doi.org/10.3390/microorganisms10061107
Several paromomycin derivatives were developed with conformationally locked side chains in order to better determine the significance of the ring I chain's aminoglycoside antibiotic binding to the ribosomal target.
Source link: https://doi.org/10.1039/d1md00214g
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