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"Impact of 98 LRRK2 variants Related to Parkinson's Disease - Impact of 98 LRRK2 variants related to Parkinson's Disease" on kinase production and microtubule binding" is a text book. Raw data files were used for the manuscript "Impact of 98 LRRK2 variants related to Parkinson's Disease. In clinical trials, mutations that promote LRRK2's kinase activity are responsible for Parkinson's disease, and drugs that reduce LRRK2 kinase activity are being tested. We find that the effect of variants on kinase activity is best evaluated by testing an in vitro kinase assay assay, as only a small number of activating variants of immunoprecipitated LRRK2-dependent Rab10 substrate phosphorylation in Thr73, comprising the COR B and kinase forms. Our findings will help determine the impact of these variants on LRRK2 kinase activation, stimulate research to determine mechanisms by which variants influence biology, and provide guidance for variant carrier inclusion or exclusion in ongoing and future LRRK2 clinical trials.
Source link: https://zenodo.org/record/6401194
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